Patents by Inventor Evan Thrush
Evan Thrush has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10326952Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.Type: GrantFiled: August 11, 2017Date of Patent: June 18, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Boaz Ran, Steve Swihart, Evan Thrush, Itay Barak
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Publication number: 20190107484Abstract: Systems for protein quantitation using a Fabry-Perot interferometer. In one arrangement, a quantitation device includes an infrared source, a sample holder, and a Fabry-Perot interferometer positioned to receive infrared radiation from the source passing through a sample on the sample holder. A band pass optical filter sets the working range of the interferometer, and radiation exiting the interferometer falls on a detector that produces a signal indicating the intensity of the received radiation. A controller causes the interferometer to be tuned to a number of different resonance wavelengths and receives the intensity signals, for determination of an absorbance spectrum.Type: ApplicationFiled: October 4, 2018Publication date: April 11, 2019Inventors: Evan Thrush, Steven Swihart, William Strong, Trey Marlowe
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Publication number: 20190072490Abstract: Devices and methods are disclosed for the substantially uniform epi-illumination of samples such as western blots using high power lasers. The uniformity of illumination is provided by particular configurations of optical diffusers, spatial or temporal laser modalities, or numbers of lasers. The increased excitation light produced by the high power lasers can enhance fluorescence emission signal strength and reduce required imaging exposure times.Type: ApplicationFiled: August 23, 2018Publication date: March 7, 2019Inventors: Evan THRUSH, Steve SWIHART
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Patent number: 10186539Abstract: An image sensor assembly having a sensor window positioned in front of an image sensor, having structure and/or characteristics to prevent the formation of condensation on the sensor window. Structure to prevent the formation of condensation includes thin films which can have anti-condensation, anti-reflective, electrically conductive, and/or thermally conductive properties. The sensor window can further have a textured surface to displace water so as to avoid condensation formation on the window surface. The sensor window, and in some embodiments a frame, can be maintained at an elevated temperature proximate to the image sensor during operation to prevent the formation of condensation.Type: GrantFiled: October 6, 2015Date of Patent: January 22, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Evan Thrush, Steve Swihart, Hari Jayamohan
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Patent number: 10104307Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.Type: GrantFiled: August 2, 2017Date of Patent: October 16, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Steve Swihart, Evan Thrush, Boaz Ran
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Patent number: 9933565Abstract: Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.Type: GrantFiled: July 15, 2016Date of Patent: April 3, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Steve Swihart, Evan Thrush, Yochanan Uri, Boaz Ran, Itay Barak, Kevin McDonald
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Publication number: 20170366768Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.Type: ApplicationFiled: August 11, 2017Publication date: December 21, 2017Inventors: Boaz RAN, Steve SWIHART, Evan THRUSH, Itay BARAK
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Patent number: 9841378Abstract: An imaging assembly and processing system that includes a sample platform having a target region which can hold a sample, where the sample can be marked with fluorescent or phosphorescent markers. The imaging assembly can have an excitation light module proximate to the sample platform that emits light to excite the markers, and a lens module positioned to receive emission light from excited markers in target region. At least one series filter assembly or interference filter can be arranged in front of, behind, or both in front of and behind the lens module. The assembly includes a light sensor and a processor and imaging module configured to process data captured by the light sensor. Images of the sample are generated based on the emission light from the sample that transmit through and are filtered by the lens assembly and series filter assembly or interference filter.Type: GrantFiled: April 29, 2015Date of Patent: December 12, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Evan Thrush, Steve Swihart, Neeraj Bhatt
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Publication number: 20170332001Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.Type: ApplicationFiled: August 2, 2017Publication date: November 16, 2017Inventors: Steve SWIHART, Evan THRUSH, Boaz RAN
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Patent number: 9794454Abstract: Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays.Type: GrantFiled: July 1, 2015Date of Patent: October 17, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Yochanan Uri, Boaz Ran, Itay Barak, Steven Swihart, Evan Thrush
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Publication number: 20170276605Abstract: Analyte arrays such as solutes in a slab-shaped gel following electrophoresis, and particularly arrays that are in excess of 3 cm square and up to 25 cm square and higher, are imaged at distances of 5 cm or less by either forming sub-images of the entire array and stitching together the sub-images by computer-based stitching technology, or by using an array of thin-film photoresponsive elements that is coextensive with the analyte array to form a single image of the array.Type: ApplicationFiled: March 28, 2017Publication date: September 28, 2017Inventors: John BARICH, Renee LEMAIRE-ADKINS, David NEAZ, Ariel NOTCOVICH, Paul PATT, Ryan SHORT, Steven SWIHART, Evan THRUSH, Trey MARLOWE
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Patent number: 9774804Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.Type: GrantFiled: December 8, 2014Date of Patent: September 26, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Boaz Ran, Steve Swihart, Evan Thrush, Itay Barak
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Patent number: 9736388Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.Type: GrantFiled: December 8, 2014Date of Patent: August 15, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Steve Swihart, Evan Thrush, Boaz Ran
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Patent number: 9618733Abstract: An imaging assembly for the viewing, imaging, and analysis of chemiluminescent or bioluminescent samples in gels or other substrates, in which an adjustable camera and lens module having a prime or fixed lens or a focusing lens is moved to change the field of view by shifting the focal plane of the camera and lens module. The imaging assembly can also include a mirror to bend or fold the optical path between the camera and lens module and the target area having a sample, in which the mirror can move in the same vertical direction as the camera and lens module. Further, the camera and lens module can be configured to more move in a diagonal direction relative to the location of the imaging target area. The imaging assembly can further have a duct system adaptable to adjust with the movement of the camera and lens module.Type: GrantFiled: July 28, 2014Date of Patent: April 11, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Steve Swihart, Evan Thrush, Evelio Perez, Kevin McDonald
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Publication number: 20170016829Abstract: Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.Type: ApplicationFiled: July 15, 2016Publication date: January 19, 2017Inventors: Steve SWIHART, Evan THRUSH, Yochanan URI, Boaz RAN, Itay BARAK, Kevin MCDONAL
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Publication number: 20160104806Abstract: An image sensor assembly having a sensor window positioned in front of an image sensor, having structure and/or characteristics to prevent the formation of condensation on the sensor window. Structure to prevent the formation of condensation includes thin films which can have anti-condensation, anti-reflective, electrically conductive, and/or thermally conductive properties. The sensor window can further have a textured surface to displace water so as to avoid condensation formation on the window surface. The sensor window, and in some embodiments a frame, can be maintained at an elevated temperature proximate to the image sensor during operation to prevent the formation of condensation.Type: ApplicationFiled: October 6, 2015Publication date: April 14, 2016Applicant: BIO-RAD LABORATORIES, INC.Inventors: EVAN THRUSH, STEVE SWIHART, HARI JAYAMOHAN
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Patent number: 9310600Abstract: An imaging assembly for the viewing, imaging, and analysis of biological, chemical, and/or biochemical samples in gels or other substrates, in which an adjustable camera and lens module, a reflex mirror, and a focal plane mirror, are configured to bend or fold an optical path in order to image a target region, and where the optical path can be reflected along non-orthogonal angles. The imaging assembly is configured to reduce the overall size of the imaging apparatus due to the angles at which the mirrors and camera and lens assembly are positioned relative to each other, which allows for the imaging of relatively larger samples in the target region.Type: GrantFiled: September 4, 2014Date of Patent: April 12, 2016Assignee: Bio-Rad Laboratories, Inc.Inventors: Evan Thrush, Evelio Perez, Steve Swihart
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Publication number: 20160028976Abstract: One embodiment of the invention is directed to an imaging device comprising an image sensor comprising an array of pixels, and a mask coupled with the image sensor, the mask configured to darken at least one pixel in the array of pixels.Type: ApplicationFiled: December 8, 2014Publication date: January 28, 2016Inventors: Boaz Ran, Steve Swihart, Evan Thrush, Itay Barak
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Publication number: 20160006910Abstract: Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays.Type: ApplicationFiled: July 1, 2015Publication date: January 7, 2016Inventors: Yochanan Uri, Boaz Ran, Itay Barak, Steven Swihart, Evan Thrush
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Publication number: 20150316479Abstract: An imaging assembly and processing system that includes a sample platform having a target region which can hold a sample, where the sample can be marked with fluorescent or phosphorescent markers. The imaging assembly can have an excitation light module proximate to the sample platform that emits light to excite the markers, and a lens module positioned to receive emission light from excited markers in target region. At least one series filter assembly or interference filter can be arranged in front of, behind, or both in front of and behind the lens module. The assembly includes a light sensor and a processor and imaging module configured to process data captured by the light sensor. Images of the sample are generated based on the emission light from the sample that transmit through and are filtered by the lens assembly and series filter assembly or interference filter.Type: ApplicationFiled: April 29, 2015Publication date: November 5, 2015Applicant: BIO-RAD LABORATORIES, INC.Inventors: EVAN THRUSH, STEVE SWIHART, Neeraj Bhatt