Patents by Inventor Everett P. Greenberg

Everett P. Greenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of inhibiting and treating bacterial biofilms by metal chelators
    Publication number: 20120142583
    Abstract: The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability of a bacterial population to develop into a biofilm.
    Type: Application
    Filed: October 20, 2008
    Publication date: June 7, 2012
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Pradeep K. Singh, Michael J. Welsh, Everett P. Greenberg
  • Methods of inhibiting and treating bacterial biofilms by metal chelators
    Patent number: 7446089
    Abstract: The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability of a bacterial population to develop into a biofilm.
    Type: Grant
    Filed: October 4, 2004
    Date of Patent: November 4, 2008
    Inventors: Pradeep K. Singh, Michael J. Welsh, Everett P. Greenberg
  • Autoinducer molecules and uses therefor
    Patent number: 7442798
    Abstract: Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal (“PQS”) molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signaling in bacteria using the compounds of the invention are also described.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: October 28, 2008
    Assignees: The University of Iowa Research Foundation, University of Rochester, East Carolina University
    Inventors: Everett C. Pesci, Barbara H. Iglewski, Jared B. J. Milbank, James P. Pearson, Andrew S. Kende, Everett P. Greenberg
  • Autoinducer molecule
    Patent number: 6936447
    Abstract: Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: August 30, 2005
    Assignees: University of Iowa Research Foundation, University of Rochester, Ithaca College
    Inventors: James P. Pearson, Kendall M. Gray, Luciano Passador, Kenneth D. Tucker, Anatol Eberhard, Barbara H. Iglewski, Everett P. Greenberg
  • Autoinducer molecule
    Patent number: 6057288
    Abstract: Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: May 2, 2000
    Assignees: University of Iowa, University of Rochester, Ithaca College
    Inventors: James P. Pearson, Kendall M. Gray, Luciano Passador, Kenneth D. Tucker, Anatol Eberhard, Barbara H. Iglewski, Everett P. Greenberg
  • Bactericidal factor in human airway surface fluid and uses thereof
    Patent number: 5939393
    Abstract: A bactericidal factor isolated from the surface fluid of airway epithelial cells and uses therefore is described. The bactericidal factor is characterized as having the following features: a) a molecular weight of less than 10 kd; b) heat stable; c) broad spectrum activity including gram positive and gram negative bacteria, fungi, and methicillin resistant Staphylococcus; and d) decreased antimicrobial activity in increasing salt concentration.
    Type: Grant
    Filed: April 17, 1997
    Date of Patent: August 17, 1999
    Assignee: University Of Iowa Research Foundation
    Inventors: Michael J. Welsh, Jeffrey J. Smith, Sue M. Travis, Everett P. Greenberg
  • Autoinducer molecule
    Patent number: 5591872
    Abstract: Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: January 7, 1997
    Assignee: The University of Iowa Research Foundation
    Inventors: James P. Pearson, Kendall M. Gray, Luciano Passador, Kenneth D. Tucker, Anatol Eberhard, Barbara H. Iglewski, Everett P. Greenberg