Patents by Inventor Evgenij Nikolaev
Evgenij Nikolaev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8946625Abstract: In a mass spectrometer that uses a space-restricted magnetic field, such as an ion cyclotron resonance mass spectrometer, ions with a wide mass range generated in an ion supply located outside the magnetic field are transported in the direction of the magnetic field lines to an ion storage device located inside the magnetic field without losing ions by guiding the ions through the region in which the magnetic field strength increases with a special ion guide. This ion guide consists of an arrangement of coaxial ring diaphragms which are alternately supplied with the phases of an RF voltage. In an alternative embodiment, the ion guide uses two wires wound in a double helix where each wire is supplied with one phase of a two-phase RF voltage.Type: GrantFiled: March 27, 2008Date of Patent: February 3, 2015Assignee: Bruker Daltonik GmbHInventors: Evgenij Nikolaev, Jochen Franzen
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Patent number: 8704173Abstract: Devices and methods for the acquisition of mass spectra with very high mass resolution in ion cyclotron resonance mass spectrometers include cylindrical ICR measuring cells with special electrode geometries to generate harmonic trapping potentials for orbiting ions. The sheath of the cylindrical cell is divided by longitudinal gaps into a multitude of sheath electrodes, which either have to carry layers with resistance profiles able to generate parabolic voltage profiles along the sheath electrodes, or which form sheath electrodes of varying width by parabolic gaps. Orbiting ions of a given mass m/z oscillate harmonically in an axial direction with the same frequency, independent of the radius of their orbit and their oscillation amplitude. Ideally, the cylinders are closed by endcaps with rotationally hyperbolic form, divided into partial electrodes. The ions are excited by dipolar excitation fields. The orbiting ion clouds are kept together for much longer periods than was possible hitherto.Type: GrantFiled: September 17, 2010Date of Patent: April 22, 2014Assignee: Bruker Daltonik GmbHInventors: Evgenij Nikolaev, Ivan Boldin, Jochen Franzen
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Patent number: 8410429Abstract: An ion cell having an axis includes a sheath of individual electrodes that extends along the axis and defines an internal volume. Adjacent individual electrodes are electrically insulated from each other. The individual electrodes each receive a DC potential and RF voltage. At least some of the individual electrodes have a width that varies in the axial direction such that an electrical effect on an axis potential varies along the axis of the ion cell.Type: GrantFiled: January 31, 2011Date of Patent: April 2, 2013Assignee: Bruker Daltonik GmbHInventors: Jochen Franzen, Gökhan Baykut, Oliver Räther, Carsten Stoermer, Evgenij Nikolaev
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Patent number: 8368012Abstract: Charged spray droplets are guided in a pseudopotential distribution generated by audio frequency voltages at electrodes of a guiding device, focusing the spray droplets toward the axis. An axial electric field profile and an axial flow profile of a drying gas in the guiding device allow the drift of different-sized droplets to be controlled in the longitudinal direction of the guiding device, so that the droplets are roughly equal in size when they leave the guiding device and finally dry up shortly after leaving. As a result, the ions are formed in a relatively small spatial region. Electrostatic potentials guide the analyte ions from this small spatial region to the entrance aperture of the inlet capillary; during this process, very light ions, especially protons and water-proton complexes, can be filtered out by a mobility filter.Type: GrantFiled: February 3, 2010Date of Patent: February 5, 2013Assignee: Bruker Daltonik GmbHInventors: Evgenij Nikolaev, Jochen Franzen
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Patent number: 8319180Abstract: The invention relates to measuring devices of an electrostatic Fourier transform mass spectrometer and measurement methods for the acquisition of mass spectra with high mass resolution. The measuring device includes electrostatic measuring cells according to the Kingdon principle, in which ions can, when appropriate voltages are applied, orbit on circular trajectories around the cylinder axis between two concentric cylindrical surfaces, which are composed of specially shaped sheath electrodes, insulated from each other by parabolic gaps, and can harmonically oscillate in the axial direction, independently of their orbiting motion. In the longitudinal direction, the two cylindrical surfaces of the measuring cell are divided by the parabolic separating gaps into different types of double-angled and tetragonal sheath electrode segments.Type: GrantFiled: August 12, 2011Date of Patent: November 27, 2012Assignee: Bruker Daltonik GmbHInventors: Evgenij Nikolaev, Jochen Franzen
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Patent number: 8287712Abstract: Components of a mixture are separated by feeding charged molecules of the components into a end surface of a suitable medium, for example a gel. The molecules are drawn in a first direction through the medium by means of an DC electric field, while at the same time being subjected to an alternating voltage with a strongly asymmetric profile in a direction transverse to the first direction. The nonlinear behavior of the electrically-generated migration causes a large number of molecules to migrate transversely out of the medium while only a small number of molecules reach the opposite end surface of the medium. A superimposed DC voltage in the transverse direction selects which of the mixture components migrate all the way through the medium in the first direction. The separated components can be sampled from the opposite end surface and from points on the upper and lower medium surfaces.Type: GrantFiled: September 22, 2006Date of Patent: October 16, 2012Assignee: Bruker Daltonik GmbHInventors: Evgenij Nikolaev, Jochen Franzen
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Publication number: 20120193529Abstract: The invention relates to devices and methods for the acquisition of mass spectra with very high mass resolution in ion cyclotron resonance mass spectrometers and methods to produce the devices. The invention presents cylindrical ICR measuring cells with special electrode geometries to generate harmonic trapping potentials for orbiting ions up to the walls of the cell. Only a single DC trapping voltage has to be applied to create the harmonic trapping potential distribution. The sheath of the cylindrical cell is divided by longitudinal gaps into a multitude of sheath electrodes, which either have to carry layers with resistance profiles able to generate parabolic voltage profiles along the sheath electrodes, or which form sheath electrodes of varying width by parabolic gaps, able to create complicated potential distributions which are harmonic on average for orbiting ions.Type: ApplicationFiled: September 17, 2010Publication date: August 2, 2012Applicant: BRUKER DALTONIK GMBHInventors: Evgenij Nikolaev, Ivan Boldin, Jochen Franzen
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Publication number: 20120043461Abstract: The invention relates to measuring devices of an electrostatic Fourier transform mass spectrometer and measurement methods for the acquisition of mass spectra with high mass resolution. The measuring device includes electrostatic measuring cells according to the Kingdon principle, in which ions can, when appropriate voltages are applied, orbit on circular trajectories around the cylinder axis between two concentric cylindrical surfaces, which are composed of specially shaped sheath electrodes, insulated from each other by parabolic gaps, and can harmonically oscillate in the axial direction, independently of their orbiting motion. In the longitudinal direction, the two cylindrical surfaces of the measuring cell are divided by the parabolic separating gaps into different types of double-angled and tetragonal sheath electrode segments.Type: ApplicationFiled: August 12, 2011Publication date: February 23, 2012Inventors: Evgenij Nikolaev, Jochen Franzen
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Publication number: 20110186728Abstract: An ion cell having an axis includes a sheath of individual electrodes that extends along the axis and defines an internal volume. Adjacent individual electrodes are electrically insulated from each other. The individual electrodes each receive a DC potential and RF voltage. At least some of the individual electrodes have a width that varies in the axial direction such that an electrical effect on an axis potential varies along the axis of the ion cell.Type: ApplicationFiled: January 31, 2011Publication date: August 4, 2011Inventors: Jochen Franzen, Gökhan Baykut, Oliver Räther, Carsten Stoermer, Evgenij Nikolaev
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Patent number: 7910881Abstract: A mass spectrometric analysis of surface material is performed by vaporizing the surface material with pulses of laser light and then collecting the vaporized material by dissolving it in a liquid. The liquid with the dissolved material is then fed to an ionization process, preferably an electrospray ionization process. The resulting ions are then analyzed with a mass spectrometer. The method is particularly suited for use with imaging mass spectrometry.Type: GrantFiled: November 21, 2007Date of Patent: March 22, 2011Assignee: Bruker Daltoniks, GmbHInventors: Evgenij Nikolaev, Jochen Franzen
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Publication number: 20100193679Abstract: Charged spray droplets are guided in a pseudopotential distribution generated by audio frequency voltages at electrodes of a guiding device, focusing the spray droplets toward the axis. An axial electric field profile and an axial flow profile of a drying gas in the guiding device allow the drift of different-sized droplets to be controlled in the longitudinal direction of the guiding device, so that the droplets are roughly equal in size when they leave the guiding device and finally dry up shortly after leaving. As a result, the ions are formed in a relatively small spatial region. Electrostatic potentials guide the analyte ions from this small spatial region to the entrance aperture of the inlet capillary; during this process, very light ions, especially protons and water-proton complexes, can be filtered out by a mobility filter.Type: ApplicationFiled: February 3, 2010Publication date: August 5, 2010Inventors: Evgenij Nikolaev, Jochen Franzen
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Patent number: 7495211Abstract: The invention relates to measuring methods and corresponding measuring cells for ion cyclotron resonance mass spectrometers (FTMS). The invention provides measuring methods with measuring cells, the ends of which each incorporate a large number of trapping electrodes, DC voltages of opposite polarities being applied across adjacent electrodes. For orbiting ions this builds up a repelling pseudopotential, which holds the ions in the measuring cell by reflection. This facilitates measurement of the image currents without the disturbing influence of RF voltages.Type: GrantFiled: October 4, 2005Date of Patent: February 24, 2009Assignee: Bruker Daltonik GmbHInventors: Jochen Franzen, Evgenij Nikolaev
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Publication number: 20080251715Abstract: In a mass spectrometer that uses a space-restricted magnetic field, such as an ion cyclotron resonance mass spectrometer, ions with a wide mass range generated in an ion supply located outside the magnetic field are transported in the direction of the magnetic field lines to an ion storage device located inside the magnetic field without losing ions by guiding the ions through the region in which the magnetic field strength increases with a special ion guide. This ion guide consists of an arrangement of coaxial ring diaphragms which are alternately supplied with the phases of an RF voltage. In an alternative embodiment, the ion guide uses two wires wound in a double helix where each wire is supplied with one phase of a two-phase RF voltage.Type: ApplicationFiled: March 27, 2008Publication date: October 16, 2008Applicant: BRUKER DALTONIK GMBHInventors: Evgenij Nikolaev, Jochen Franzen
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Publication number: 20080128614Abstract: A mass spectrometric analysis of surface material is performed by vaporizing the surface material with pulses of laser light and then collecting the vaporized material by dissolving it in a liquid. The liquid with the dissolved material is then fed to an ionization process, preferably an electrospray ionization process. The resulting ions are then analyzed with a mass spectrometer. The method is particularly suited for use with imaging mass spectrometry.Type: ApplicationFiled: November 21, 2007Publication date: June 5, 2008Inventors: Evgenij Nikolaev, Jochen Franzen
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Patent number: 7368711Abstract: The invention relates to a measuring cell for an ion cyclotron resonance mass spectrometer (FTMS). The invention provides a measuring cell which, on the one hand, consists of two ion-repelling RF grids at the front ends as trapping electrodes and thus produces a pure cyclotron motion of the ions without the usually co-existing magnetron motion and, on the other hand, measures a multiplied cyclotron frequency by means of a plurality of detection electrodes, whereby either a higher mass accuracy or a shorter measuring time can be achieved.Type: GrantFiled: August 4, 2005Date of Patent: May 6, 2008Assignee: Bruker Daltonik GmbHInventors: Jochen Franzen, Evgenij Nikolaev
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Patent number: 7205537Abstract: The invention relates to an ion guide consisting of RF multipole segments to transfer ions from an ion source into a mass analyzer. The invention consists in having movable RF multipole segments in the ion guide which extend or electrically connect other RF multipole segments along the axis of the ion guide, in which spaces have arisen as a result of a change in configuration of the mass spectrometer, comprising ion source, ion guide and mass analyzer. The moved RF multipole segments bridge the spaces which have arisen between the components of the mass spectrometer and facilitate the transfer of the ions from the ion source to the mass analyzer.Type: GrantFiled: June 7, 2005Date of Patent: April 17, 2007Assignee: Bruker Daltonic GmbHInventor: Evgenij Nikolaev
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Publication number: 20070068817Abstract: Components of a mixture are separated by feeding charged molecules of the components into a end surface of a suitable medium, for example a gel. The molecules are drawn in a first direction through the medium by means of an DC electric field, while at the same time being subjected to an alternating voltage with a strongly asymmetric profile in a direction transverse to the first direction. The nonlinear behavior of the electrically-generated migration causes a large number of molecules to migrate transversely out of the medium while only a small number of molecules reach the opposite end surface of the medium. A superimposed DC voltage in the transverse direction selects which of the mixture components migrate all the way through the medium in the first direction. The separated components can be sampled from the opposite end surface and from points on the upper and lower medium surfaces.Type: ApplicationFiled: September 22, 2006Publication date: March 29, 2007Applicant: Bruker Daltonik GmbHInventors: Evgenij Nikolaev, Jochen Franzen
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Patent number: 7196326Abstract: The invention relates to a reaction cell for reactions between different types of ion species and a related mass spectrometer to analyze the ion products. The invention consists in an RF-operated straight ion guide with a side inlet, particularly suitable for reactions between positive and negative ion species, one ion species being fed in through the side inlet. Particularly favorable is an ion guide made up of a set of coaxial apertured diaphragms with a slight axial potential gradient. The reactions can be used for a fragmentation of multiply charged protein or peptide ions by electron transfer, or for the removal of excess charges of multiply charged biopolymer ions, for example.Type: GrantFiled: June 10, 2005Date of Patent: March 27, 2007Assignee: Bruker Daltonik GmbHInventors: Jochen Franzen, Evgenij Nikolaev
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Publication number: 20060226357Abstract: The invention relates to measuring methods and corresponding measuring cells for ion cyclotron resonance mass spectrometers (FTMS). The invention provides measuring methods with measuring cells, the ends of which each incorporate a large number of trapping electrodes, DC voltages of opposite polarities being applied across adjacent electrodes. For orbiting ions this builds up a repelling pseudopotential, which holds the ions in the measuring cell by reflection.Type: ApplicationFiled: October 4, 2005Publication date: October 12, 2006Applicant: Bruker Daltonik GmbHInventors: Jochen Franzen, Evgenij Nikolaev
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Patent number: 7038200Abstract: The invention describes an ion cyclotron resonance (ICR) mass spectrometer with an ICR trap, the ICR trap having as trapping electrodes two ion reflecting electrode structures operated by RF voltages without any DC voltage. The usual apertured ion trapping electrodes are replaced by multitudes of structural elements, electrically conducting, and repeating spatially in one or two directions of a surface, neighboring structure elements being connected each to different phases of an RF voltage. In the simplest case a grid of parallel wires can be used. The surface of such structures reflects ions of both polarities, if the mass-to-charge ratio of the ions is higher than a threshold.Type: GrantFiled: April 28, 2004Date of Patent: May 2, 2006Assignee: Bruker Daltonik GmbHInventor: Evgenij Nikolaev