Patents by Inventor Ewen MacDonald

Ewen MacDonald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazoles for the treatment of age-related cognitive disorders and alzheimer
    Patent number: 5434177
    Abstract: This invention relates to the use of a compound of formula ##STR1## wherein X is --CH.sub.2 -- or ##STR2## R.sub.1 is H, C.sub.1-5 -alkyl or benzyl, which can be substituted of unsubstituted; R.sub.2 is H, C.sub.1-4 -alkyl, C.sub.1-4 -alkenyl, OH, or C.sub.1-3 -alkoxy; R.sub.3 is H, CH.sub.3, C.sub.2 CH.sub.3, OCH.sub.3, or Hal; R.sub.4 H, CH.sub.3, C.sub.2 CH.sub.3, OCH.sub.3, or Hal, and Hal is halogen, provided that when R.sub.2 is OH or C.sub.1-3 -alkoxy then X cannot be CO or a non-toxic pharmaceutically acceptable salt thereof for the use in the treatment of age related memory impairment or cognitive disorders, particularly Alzheimer's Disease.
    Type: Grant
    Filed: November 30, 1992
    Date of Patent: July 18, 1995
    Assignee: Orion-Yhtyma Oy
    Inventors: Paavo J. Riekkinen, Paavo Riekkinen, Jr., Jouni S. I. Sirvio, Riitta A. Miettinen, Antti Valjakka, Mauno M. Airaksinen, Sakari A. Nieminen, Ewen MacDonald, Risto A. S. Lammintausta, Raimo E. Virtanen
  • Compositions and their use in lowering intraocular pressure
    Patent number: 5304569
    Abstract: Compounds of formula: ##STR1## where X is --CH.sub.2 --, --CH(CH.sub.3)--, --CHR.sub.3 --CH.sub.2 -- or --CR.sub.3 .dbd.CH-- and R.sub.1, R.sub.2 and R.sub.3, which can be the same or different, are each H or CH.sub.3 or a stereoisomer or pharmaceutically acceptable salt thereof, and pharmaceutical compositions containing them, are useful for lowering intraocular pressure in a mammal, e.g. in the treatment of glaucoma.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: April 19, 1994
    Assignee: Orion-yhtyma Oy
    Inventors: Risto Lammintausta, Arto Karjalainen, Ewen MacDonald, Arto Urtti, Raimo Virtanen, Thomas Yorio