Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

Abstract: In a marine vessel adapted to carry liquids such as crude oil which embodies a certain amount of solid residue, apparatus is provided for removing the latter from the vessel's storage tanks. The liquid crude is normally removed by a manifolded discharge or eductor system communicated with the suction side of a pump. The eductor system includes a plurality of individually controlled open ended discharge conduits, each conduit being fixedly positioned with its inlet port spaced above the floor of the tank to withdraw liquid from the tank. A portable cleaning apparatus is provided to remove accumulated sludge and the like from the tank floor, which cleaning apparatus is adapted to removably engage a discharge conduit whereby to ingest sludge from the latter.