Patents by Inventor Fabrice Manns
Fabrice Manns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230194734Abstract: Systems and methods for an improved dosimeter for measuring dosage for photodynamic therapy treatment are provided. An example systems includes a dosimeter comprising a variable optical filter system configured to receive a second light, the second light comprising luminescence produced by singlet oxygen and one or more background signal and selectively transmit the luminescence and the one or more background signals as a third light, the variable optical filter system comprises a plurality of optical bandpass filters that are switchable to selectively transmit the luminescence and the one or more background signals. The dosimeter also includes a photoreceiver configured to receive the third light and configured to generate electrical output signals corresponding to the luminescence and the one or more background signals, the electrical output signals being indicative of an amount of the singlet oxygen produced based on activating the photosensitizer.Type: ApplicationFiled: May 21, 2021Publication date: June 22, 2023Inventors: Jeffrey Carl Peterson, Jean-Marie Parel, Fabrice Manns, Marco Ruggeri
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Publication number: 20230064504Abstract: System for combined intraoperative aberrometry and optical coherence tomography (OCT). In an embodiment, the system comprises an OCT system, an aberrometer, a beam delivery system, and a beam splitter. The beam delivery system is configured to output a beam towards a target, wherein the beam has an outward path to the target and a return path after being reflected by the target. The beam splitter is positioned in the return path of the beam and configured to split the return path into a first path to the OCT system and a second path to the aberrometer. Thus, the OCT system and aberrometer can share a single beam delivery system.Type: ApplicationFiled: January 29, 2021Publication date: March 2, 2023Inventors: Marco Ruggeri, Fabrice Manns, Heather Durkee
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Publication number: 20190254517Abstract: An ophthalmic refractor is described that provides a non-linear relationship between spherical power and refractive error by positioning a reference plane for a sensor system of the refractor in front of the cornea. The refractor may have a working distance and dynamic range that enable it to be mounted on a surgical microscope. Also described are computational methods for analysing the output from the ophthalmic refractor, utilising error minimisation, linear regression and Fourier Transform analysis.Type: ApplicationFiled: January 7, 2019Publication date: August 22, 2019Inventors: Fabrice Manns, Manuel Bacci, David Borja, Stephanie Delgado, Jean-Marie Parel, Arthur Ho, Richard Shelby, Lutz Andersohn, Andres Bernal
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Publication number: 20190223713Abstract: Systems, methods and apparatuses for an intraocular imaging system are disclosed comprising an optical coherence tomography (OCT) system. The OCT system has an imaging range that may enable substantial portions of an eye or even a whole eye to be imaged. The OCT system may be coupled to an operation microscope, such that, for example, a surgeon can visualize ocular structures like the human crystalline lens and other ocular structures such as the cornea and/or vitreous while surgical instruments are in the field of view.Type: ApplicationFiled: January 4, 2019Publication date: July 25, 2019Inventors: Stephen Roger Uhlhorn, Marco Ruggeri, Fabrice Manns, Jean-Marie Arthur Parel
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Patent number: 10219690Abstract: An ophthalmic refractor is described that provides a non-linear relationship between spherical power and refractive error by positioning a reference plane for a sensor system of the refractor in front of the cornea. The refractor may have a working distance and dynamic range that enable it to be mounted on a surgical microscope. Also described are computational methods for analysing the output from the ophthalmic refractor, utilising error minimisation, linear regression and Fourier Transform analysis.Type: GrantFiled: March 14, 2012Date of Patent: March 5, 2019Assignee: Adventus Technologies, Inc.Inventors: Fabrice Manns, Manuel Bacci, David Borja, Stephanie Delgado, Jean-Marie Parel, Arthur Ho, Richard Allen Shelby, Lutz Andersohn, Andres Bernal
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Patent number: 10213101Abstract: Systems, methods and apparatuses for an intraocular imaging system are disclosed comprising an optical coherence tomography (OCT) system. The OCT system has an imaging range that may enable substantial portions of an eye or even a whole eye to be imaged. The OCT system may be coupled to an operation microscope, such that, for example, a surgeon can visualize ocular structures like the human crystalline lens and other ocular structures such as the cornea and/or vitreous while surgical instruments are in the field of view.Type: GrantFiled: October 14, 2016Date of Patent: February 26, 2019Assignee: Adventus Technologies, Inc.Inventors: Stephen Roger Uhlhorn, Marco Ruggeri, Fabrice Manns, Jean-Marie Arthur Parel
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Publication number: 20170027438Abstract: Systems, methods and apparatuses for an intraocular imaging system are disclosed comprising an optical coherence tomography (OCT) system. The OCT system has an imaging range that may enable substantial portions of an eye or even a whole eye to be imaged. The OCT system may be coupled to an operation microscope, such that, for example, a surgeon can visualize ocular structures like the human crystalline lens and other ocular structures such as the cornea and/or vitreous while surgical instruments are in the field of view.Type: ApplicationFiled: October 14, 2016Publication date: February 2, 2017Inventors: Stephen Roger Uhlhorn, Marco Ruggeri, Fabrice Manns, Jean-Marie Arthur Parel
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Patent number: 9492080Abstract: Systems, methods and apparatuses for an intraocular imaging system are disclosed comprising an optical coherence tomography (OCT) system. The OCT system has an imaging range that may enable substantial portions of an eye or even a whole eye to be imaged. The OCT system may be coupled to an operation microscope, such that, for example, a surgeon can visualize ocular structures like the human crystalline lens and other ocular structures such as the cornea and/or vitreous while surgical instruments are in the field of view.Type: GrantFiled: May 1, 2015Date of Patent: November 15, 2016Assignee: Adventus Technologies, IncInventors: Stephen Roger Uhlhorn, Marco Ruggeri, Fabrice Manns, Jean-Marie Arthur Parel
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Publication number: 20150230702Abstract: Systems, methods and apparatuses for an intraocular imaging system are disclosed comprising an optical coherence tomography (OCT) system. The OCT system has an imaging range that may enable substantial portions of an eye or even a whole eye to be imaged. The OCT system may be coupled to an operation microscope, such that, for example, a surgeon can visualize ocular structures like the human crystalline lens and other ocular structures such as the cornea and/or vitreous while surgical instruments are in the field of view.Type: ApplicationFiled: May 1, 2015Publication date: August 20, 2015Inventors: Stephen Roger Uhlhorn, Marco Ruggeri, Fabrice Manns, Jean-Marie Arthur Parel
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Patent number: 9050027Abstract: Systems, methods and apparatuses for an intraocular imaging system are disclosed comprising an optical coherence tomography (OCT) system. The OCT system has an imaging range that may enable substantial portions of an eye or even a whole eye to be imaged. The OCT system may be coupled to an operation microscope, such that, for example, a surgeon can visualize ocular structures like the human crystalline lens and other ocular structures such as the cornea and/or vitreous while surgical instruments are in the field of view.Type: GrantFiled: December 1, 2011Date of Patent: June 9, 2015Assignee: Adventus Technologies, Inc.Inventors: Stephen Roger Uhlhorn, Marco Ruggeri, Fabrice Manns, Jean-Marie Arthur Parel
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Patent number: 8974059Abstract: A small animal imaging system comprising a base element and a camera coupled to the base element, the camera being sized to image the eye of a small animal. A light-emitting diode is also included coupled to the base element. An OCT imaging apparatus is also included coupled to the base element. An X-Y scanner is also included coupled to the base element in communication with the OCT imaging apparatus.Type: GrantFiled: December 2, 2009Date of Patent: March 10, 2015Assignee: University of MiamiInventors: Omer Kocaoglu, Stephen Uhlhorn, Eleut Hernandez, Vittorio Porciatti, Jean-Marie Parel, Fabrice Manns
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Patent number: 8606346Abstract: A method of thermally inducing and monitoring changes to localized regions of tissue by illuminating a volume of tissue with a first beam of X-rays, detecting portions of the first beam that passed through the volume, generating a first image signal from the portions of the first beam detected, applying heat to at least a localized region of tissue within the volume after the illuminating and detecting, illuminating the volume with a second beam of X-rays, detecting portions of the second beam that passed through the volume during the illuminating with the second beam, generating a second image signal from the portions of the second beam detected, and generating a difference image signal based upon a comparison of the first and second image signals. The difference image signal provides information of changes in X-ray attenuation by localized regions of tissue within the volume due to the application of heat.Type: GrantFiled: November 4, 2011Date of Patent: December 10, 2013Assignee: University of MiamiInventors: Jean-Marie Parel, Fabrice Manns, David S. Robinson, Peter Milne, David B. Denham, Xochitl Gonzalez-Cirre
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Patent number: 8439974Abstract: The present invention relates to a method of determining the IOL refractive index for an ocular replacement material for replacing tissue in the capsular bag comprising combining a neutral (non-correcting) reference refractive index (“NRRI”) of between 1.421 and 1.450 with a refractive index correction factor (“RICF”) ascertained by reference to the refractive power required to correct the patient's refractive error. The present invention also relates to methods of treating presbyopia, myopia and hyperopia using the above method.Type: GrantFiled: May 3, 2007Date of Patent: May 14, 2013Assignee: Vision CRC LimitedInventors: Arthur Ho, Brien Anthony Holden, Fabrice Manns, Jean-Marie Arthur Parel
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Patent number: 8425037Abstract: Systems, methods and apparatuses for intraocular imaging system are disclosed comprising an optical coherence tomography (OCT) system. The OCT system has an imaging range that may enable substantial portions of an eye to be imaged. The OCT system may be coupled to an operation microscope, such that, for example, a surgeon can visualize ocular structures like the human crystalline lens and other ocular structures such as the cornea and/or vitreous while surgical instruments are in the field of view.Type: GrantFiled: July 29, 2011Date of Patent: April 23, 2013Assignee: Adventus Technologies, Inc.Inventors: Stephen Uhlhorn, Marco Ruggeri, Fabrice Manns, Jean-Marie Arthur Parel
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Publication number: 20120238904Abstract: An ophthalmic refractor is described that provides a non-linear relationship between spherical power and refractive error by positioning a reference plane for a sensor system of the refractor in front of the cornea. The refractor may have a working distance and dynamic range that enable it to be mounted on a surgical microscope. Also described are computational methods for analysing the output from the ophthalmic refractor, utilising error minimisation, linear regression and Fourier Transform analysis.Type: ApplicationFiled: March 14, 2012Publication date: September 20, 2012Inventors: Fabrice Manns, Manuel Bacci, David Borja, Stephanie Delgado, Jean-Marie Parel, Arthur Ho, Richard Allen Shelby, Lutz Andersohn, Andres Bernal
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Publication number: 20120140173Abstract: Systems, methods and apparatuses for an intraocular imaging system are disclosed comprising an optical coherence tomography (OCT) system. The OCT system has an imaging range that may enable substantial portions of an eye or even a whole eye to be imaged. The OCT system may be coupled to an operation microscope, such that, for example, a surgeon can visualize ocular structures like the human crystalline lens and other ocular structures such as the cornea and/or vitreous while surgical instruments are in the field of view.Type: ApplicationFiled: December 1, 2011Publication date: June 7, 2012Inventors: Stephen Roger Uhlhorn, Marco Ruggeri, Fabrice Manns, Jean-Marie Arthur Parel
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Publication number: 20120101375Abstract: A method of thermally inducing and monitoring changes to localized regions of tissue illuminating a volume of tissue with a first beam of X-rays, detecting portions of the first beam that passed through the volume, generating a first image signal from the portions of the first beam detected, applying heat to at least a localized region of tissue within the volume after the illuminating and detecting, illuminating the volume with a second beam of X-rays, detecting portions of the second beam that passed through the volume during the illuminating with the second beam, generating a second image signal from the portions of the second beam detected, and generating a difference image signal based upon a comparison of the first and second image signals. The difference image signal provides information of changes in X-ray attenuation by localized regions of tissue within the volume due to the application of heat.Type: ApplicationFiled: November 4, 2011Publication date: April 26, 2012Applicant: University of MiamiInventors: Jean-Marie Parel, Fabrice Manns, David S. Robinson, Peter Milne, David B. Denham, Xochitl Gonzalez-Cirre
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Publication number: 20120026462Abstract: Systems, methods and apparatuses for intraocular imaging system are disclosed comprising an optical coherence tomography (OCT) system. The OCT system has an imaging range that may enable substantial portions of an eye to be imaged. The OCT system may be coupled to an operation microscope, such that, for example, a surgeon can visualize ocular structures like the human crystalline lens and other ocular structures such as the cornea and/or vitreous while surgical instruments are in the field of view.Type: ApplicationFiled: July 29, 2011Publication date: February 2, 2012Inventors: Stephen Uhlhorn, Marco Ruggeri, Fabrice Manns, Jean-Marie Arthur Parel
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Patent number: 8099147Abstract: A method of thermally inducing and monitoring changes to localized regions of tissue illuminating a volume of tissue with a first beam of X-rays, detecting the portions of the first beam of X-rays that passed through the volume of tissue, generating a first X-ray image signal from the portions of X10 rays of the first beam detected, applying heat to at least a localized region of tissue within the volume of tissue after the illuminating and after the detecting, illuminating the volume of tissue with a second beam of X-rays, detecting portions of the second beam of X-rays that passed through the volume of tissue during the illuminating with the second beam of X-rays, generating a second X-ray image signal from the portions of X-rays of the second beam detected, and generating a difference image signal based upon a comparison of the first and second X-ray image signals.Type: GrantFiled: April 14, 2008Date of Patent: January 17, 2012Assignee: University of MiamiInventors: Jean-Marie Parel, Fabrice Manns, David S. Robinson, Peter Milne, David B. Denham, Xochitl Gonzalez-Cirre
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Publication number: 20110234976Abstract: A small animal imaging system comprising a base element and a camera coupled to the base element, the camera being sized to image the eye of a small animal. A light-emitting diode is also included coupled to the base element. An OCT imaging apparatus is also included coupled to the base element. An X-Y scanner is also included coupled to the base element in communication with the OCT imaging apparatus.Type: ApplicationFiled: December 2, 2009Publication date: September 29, 2011Applicant: UNIVERSITY OF MIAMIInventors: Omer Kocaoglu, Stephen Uhlhorn, Eleut Hernandez, Vittorio Porciatti, Jean-Marie Parel, Fabrice Manns