Patents by Inventor Fabrice Pagniez

Fabrice Pagniez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIFUNGAL PRODRUGS
    Publication number: 20230218652
    Abstract: The invention relates to an antifungal prodrug which comprises an antifungal moiety which is linked to a trigger moiety by means of a self-immolative spacer. The trigger moiety is selected from glycosyl residues and oligosaccharides, stabilizes the self-immolative spacer and is cleavable by a pathogen hydrolytic enzyme which is preferably an extracellular glycosidase (EC 3.2.1). When the trigger moiety is cleaved by the pathogen hydrolytic enzyme, the self-immolative spacer undergoes a spontaneous degradation so as to release the antifungal moiety. The invention also relates to pharmaceutical compositions comprising said prodrug and to its use in the treatment of infectious diseases.
    Type: Application
    Filed: May 28, 2021
    Publication date: July 13, 2023
    Inventors: ARNAUD TESSIER, PATRICE LE PAPE, JACQUES LEBRETON, FABRICE PAGNIEZ, GILLES-OLIVIER GRATIEN
  • Fused pyrimidinone and triazinone derivatives containing bridged nitrogen, their process of preparation and their therapeutic uses as antifungal and/or antiparasitic agents
    Patent number: 10626115
    Abstract: The present invention concerns novel fused pyrimidinone and triazinone derivatives containing bridged nitrogen, their process of preparation and their use as antifungal or antiparasitic agents.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: April 21, 2020
    Assignee: UNIVERSITE DE NANTES
    Inventors: Cédric Loge, Rémi Guillon, David Montoir, Fabrice Pagniez, Patrice Le Pape
  • NOVEL FUSED PYRIMIDINONE AND TRIAZINONE DERIVATIVES CONTAINING BRIDGED NITROGEN, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC USES AS ANTIFUNGAL AND/OR ANTIPARASITIC AGENTS
    Publication number: 20190002467
    Abstract: The present invention concerns novel fused pyrimidinone and triazinone derivatives containing bridged nitrogen, their process of preparation and their use as antifungal or antiparasitic agents.
    Type: Application
    Filed: July 22, 2016
    Publication date: January 3, 2019
    Applicant: UNIVERSITE DE NANTES
    Inventors: Cédric LOGE, Rémi GUILLON, David MONTOIR, Fabrice PAGNIEZ, Patrice LE PAPE
  • Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition
    Publication number: 20040067998
    Abstract: The present invention relates to novel indole derivatives, their method of preparation and their pharmacological activity as antimycotic and/or antiparasitic compounds.
    Type: Application
    Filed: July 25, 2003
    Publication date: April 8, 2004
    Inventors: Marc Le Borgne, Young Min Na, Fabrice Pagniez, Guillaume Le Baut, Patrice Le Pape, Hiam Abdala