Patents by Inventor Fabrizio Manetti

Fabrizio Manetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway
    Patent number: 9073835
    Abstract: The present invention relates to the use of acylthiourea or acylurea derivatives for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, and also to novel acylthiourea or acylurea derivatives as such, to their use as a medicinal product, and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: July 7, 2015
    Assignees: Centre National De La Recherche Scientifique, Universite De Strasbourg
    Inventors: Martial Ruat, Hélène Faure, Elisabeth Traiffort, Angèle Schoenfelder, André Mann, Maurizio Taddei, Antonio Solinas, Fabrizio Manetti
  • Quinolinone derivatives
    Patent number: 9061997
    Abstract: The present invention relates to compounds which are quinolinone derivatives of general formula (I) capable of modulating the activity, in particular of inducing the differentiation, of stem and progenitor cells; these compounds are of use in the treatment of disorders related to a stem differentiation defect; the invention also relates to novel compounds among these quinolinone derivatives and to pharmaceutical compositions containing the same.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: June 23, 2015
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Martial Ruat, Hélène Faure, Tatiana Gorojankina, André Mann, Maurizio Taddei, Fabrizio Manetti, Antonio Solinas
  • Acyl guanidine derivatives modulating the hedgehog protein signaling pathway
    Patent number: 8889678
    Abstract: The present invention relates to acyl guanidine derivatives modulating the hedgehog protein signaling pathway to be used as drugs, in particular for treating diseases involving a tissue dysfunction associated with a deregulation of the hedgehog protein signaling pathway, as well as to pharmaceutical compositions containing same. The present invention also relates to novel acyl guanidine derivatives as such.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: November 18, 2014
    Assignees: Centre National de la Recherche Scientifique, Universite de Strasbourg
    Inventors: Martial Ruat, Hélène Faure, Elisabeth Traiffort, Hermine Roudaut, André Mann, Angèle Schoenfelder, Maurizio Taddei, Fabrizio Manetti, Antonio Solinas
  • Quinolinone Derivatives
    Publication number: 20130267559
    Abstract: The present invention relates to compounds which are quinolinone derivatives of general formula (I) capable of modulating the activity, in particular of inducing the differentiation, of stem and progenitor cells; these compounds are of use in the treatment of disorders related to a stem differentiation defect; the invention also relates to novel compounds among these quinolinone derivatives and to pharmaceutical compositions containing the same.
    Type: Application
    Filed: November 15, 2011
    Publication date: October 10, 2013
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Martial Ruat, Helene Faure, Tatiana Gorojankina, Andre Mann, Maurizio Taddei, Fabrizio Manetti, Antonio Solinas
  • 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof
    Patent number: 8466164
    Abstract: The present invention relates to a compound 4-substituted derivative of pyrazolo[3,4-d]pyrimidine or of pyrrolo[2,3-d]pyrimidine having the formula (I) and uses thereof, in particular for the treatment of bone related diseases and tumors.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: June 18, 2013
    Assignee: Universita degli Studi di Siena
    Inventors: Silvia Schenone, Francesco Bondavalli, Olga Bruno, Maurizio Botta, Fabrizio Manetti, Marco Radi, Alessandra Santucci, Giovanni Maga, Mauro Bologna, Adriano Angelucci, Annalisa Santucci, Adriano Spreafico, Fabio Carraro, Jurgen Borlak
  • Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof and intermediates thereto
    Patent number: 8304410
    Abstract: The present invention relates to compounds having formula 3 as well as the synthesis, intermediates and methods of using the same.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: November 6, 2012
    Assignees: Università degli Studi di Roma “La Sapienza”, Università degli Studi di Siena
    Inventors: Mariangela Biava, Giulio Cesare Porretta, Raffaello Pompei, Maurizio Botta, Fabrizio Manetti, Alessandro De Logu
  • Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway
    Publication number: 20120196865
    Abstract: The present invention relates to acyl guanidine derivatives modulating the hedgehog protein signaling pathway to be used as drugs, in particular for treating diseases involving a tissue dysfunction associated with a deregulation of the hedgehog protein signaling pathway, as well as to pharmaceutical compositions containing same. The present invention also relates to novel acyl guanidine derivatives as such.
    Type: Application
    Filed: July 19, 2010
    Publication date: August 2, 2012
    Applicants: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Martial Ruat, Hélène Faure, Elisabeth Traiffort, Hermine Roudaut, André Mann, Angèle Schoenfelder, Maurizio Taddei, Fabrizio Manetti, Antonio Solinas
  • N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway
    Publication number: 20110275663
    Abstract: The present invention relates to the use of acylthiourea or acylurea derivatives for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, and also to novel acylthiourea or acylurea derivatives as such, to their use as a medicinal product, and to pharmaceutical compositions containing them.
    Type: Application
    Filed: April 16, 2009
    Publication date: November 10, 2011
    Inventors: Martial Ruat, Hélène Faure, Elisabeth Traiffort, Angèle Schoenfelder, André Mann, Maurizio Taddei, Antonio Solinas, Fabrizio Manetti
  • Derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine, synthesis process and uses thereof
    Patent number: 8012970
    Abstract: The present invention concerns pyrrole compounds, derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine (BM212). The invention concerns the use of the described compounds as antitubercular agents having high activity and low toxicity and process to obtain intermediates and final compounds.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: September 6, 2011
    Assignee: Universta' Degli Studi di Siena
    Inventors: Mariangela Biava, Fabrizio Manetti, Delia Deidda, Raffaello Pompei, Maurizio Botta, Giulio Cesare Porretta
  • Derivatives of 1--4-methylpiperazine, synthesis process and uses thereof
    Publication number: 20110144109
    Abstract: The present invention concerns pyrrole compounds, derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine (BM212). The invention concerns the use of the described compounds as antitubercular agents having high activity and low toxicity and process to obtain intermediates and final compounds.
    Type: Application
    Filed: February 23, 2011
    Publication date: June 16, 2011
    Inventors: Mariangela BIAVA, Fabrizio MANETTI, Delia DEIDDA, Raffaello POMPEI, Maurizio BOTTA, Giulio Cesare PORRETTA
  • Derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl] methyl}-4-methylpiperazine, synthesis process and uses thereof
    Patent number: 7910581
    Abstract: The present invention concerns pyrrole compounds, derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine (BM212). The invention concerns the use of the described compounds as antitubercular agents having high activity and low toxicity and process to obtain intermediates and final compounds.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: March 22, 2011
    Inventors: Mariangela Biava, Fabrizio Manetti, Delia Deidda, Raffaello Pompei, Maurizio Botta, Giulio Cesare Porretta
  • NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-D PYRIMIDINE AND PYRROLO[2,3-D]PYRIMIDINE AND USES THEREOF
    Publication number: 20100249152
    Abstract: The present invention relates to a compound 4-substituted derivative of pyrazolo[3,4-d]pyrimidine or of pyrrolo[2,3-d]pyrimidine having the formula (I) and uses thereof, in particular for the treatment of bone related diseases and tumours.
    Type: Application
    Filed: September 12, 2008
    Publication date: September 30, 2010
    Applicant: UNIVERSITA DEGLI STUDI DI SIENA
    Inventors: Silvia Schenone, Francesco Bondavalli, Olga Bruno, Maurizio Botta, Fabrizio Manetti, Marco Radi, Alessandra Santucci, Giovanni Maga, Mauro Bologna, Adriano Angelucci, Annalisa Santucci, Adriano Spreafico, Fabio Carraro, Jurgen Borlak
  • PYRROLE COMPOUNDS AS INHIBITORS OF MYCOBACTERIA, SYNTHESIS THEREOF AND INTERMEDIATES THERETO
    Publication number: 20100197672
    Abstract: The present invention relates to a compound having the general formula (3): synthesis, intermediates and uses thereof.
    Type: Application
    Filed: September 25, 2008
    Publication date: August 5, 2010
    Applicants: UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA", UNIVERSITA DEGLI STUDI DI SIENA
    Inventors: Mariangela Biava, Giulio Cesare Porretta, Raffaello Pompei, Maurizio Botta, Fabrizio Manetti, Alessandro De Logu
  • Derivatives of 1--4-methylpiperazine, synthesis process and uses thereof
    Publication number: 20090281094
    Abstract: The present invention concerns pyrrole compounds, derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine (BM212). The invention concerns the use of the described compounds as antitubercular agents having high activity and low toxicity and process to obtain intermediates and final compounds.
    Type: Application
    Filed: March 3, 2006
    Publication date: November 12, 2009
    Inventors: Mariangela Biava, Fabrizio Manetti, Delia Deidda, Raffaello Pompei, Maurizio Botta, Giulio Cesare Porretta
  • Substituted pyrazolo[3,4-D]pyrimidines as anti-tumor agents
    Patent number: 7589086
    Abstract: The present invention provides a compound of pyrazolo[3,4-d]pyrimidine having the formula wherein: X=N; R=H, alkylthio, or aminoalkylthio; R1=NHcyclopropyl, NHC3H7, NHC4H9, N(CH2CH3)2, NHCH2CH2OC2H5, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, NHcyclohexyl, 1-hexahydroazepinyl, NHCH2C6H5, or NHCH2CH2C6H5; wherein R3=H, halogen, or alkyl and R5=Cl, Br or OH.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: September 15, 2009
    Assignee: Universita degli Studi di Siena
    Inventors: Francesco Bondavalli, Maurizio Botta, Olga Bruno, Fabrizio Manetti, Silvia Schenone, Fabio Carraro
  • 4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof
    Publication number: 20070010510
    Abstract: 4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. Compounds are active as antitumoural agents.
    Type: Application
    Filed: May 26, 2004
    Publication date: January 11, 2007
    Inventors: Francesco Bondavalli, Maurizio Botta, Olga Bruno, Fabrizio Manetti, Silvia Schenone, Fabio Carraro