Abstract: A compound, as represented by formula I, as a TLR7 agonist, a method for preparing the compound, and the use of the compound in treating diseases mediated by the TLR7 agonist are provided. Studies on the activity of a human-derived receptor, a TLR7 agonist, show that compounds have a strong agonistic effect on the human-derived receptor, TLR7, and can be used as a foreground compound for treating diseases mediated by the TLR7 agonist.

Abstract: A first set of features associated with a neural network are parameterized. A decision tree is generated from the first set of features. One or more adjustments for the neural network are received at the decision tree. A second set of features associated with the adjustments at the decision tree are parameterized. The parameterized first and second set of features are combined into a plurality of parameters. From the plurality, an adjusted neural network is generated.

Abstract: A system and method for table conversion including converting a table containing text in tabular form to an image, labeling each text area of the image with a bounding box, determining for each bounding box, a position information, a semantic information, and an image information, reconstructing the image into a graph form having a plurality of nodes, wherein each node represents the bounding box of the text areas of the image, inputting at least two nodes into a trained neural network to determine a relative relationship between the at least two nodes, building a knowledge graph using the relative relationship of the at least two nodes, and translating the knowledge graph into machine readable natural language.

Abstract: A method, computer program product, and computer system for generating and using a basic state layer. N task models are provided (N?2). Each task model was trained on a same pre-trained backbone model. Each task model includes M feature layers and a task layer (M?1). Each feature layer of each task model includes a parameter matrix that is different for the different models. An encoder-decoder model is trained. The encoder-decoder model includes sequentially: an input layer, an encoder, M hidden layers, a decoder, and an output layer. The encoder is a neural network that maps and compresses the parameter matrices in the input layer into the M hidden layers, which generates a basic state model. The decoder is a neural network that receives the basic state model as input and generates the output layer to be identical to the input layer.

Abstract: The present invention relates to a method and system for quantitatively evaluating surface roughness of an organic pore of kerogen in shale. The method includes: making a shale sample; applying a circle of silver-painted conductive tape on the edge of the shale sample to obtain a processed sample; conducting image scanning on the processed sample to obtain a scanned image; determining a kerogen area according to the scanned image; determining an organic pore area according to the kerogen area; carrying out gridding treatment on the organic pore area to obtain multiple grid cells; adopting double integral calculation on each of the grid cells to obtain the areas of the multiple grid cells; summing each of the areas to obtain the surface area of the organic pore; and evaluating surface roughness of the organic pore according to the surface area of the pore.

Abstract: Disclosed is a linear motor, including a mover and a stator which cooperate with each other. The mover includes mover iron cores arranged at intervals in a movement direction of the mover, and the stator includes permanent magnets arranged at intervals in the movement direction. Each of the mover iron cores includes an iron core yoke portion and an iron core tooth unit joined to each other. The iron core tooth unit defines an opening, and each of the permanent magnets is located at least partially within the opening.

Abstract: The present disclosure provides a screen detection method, an apparatus and a device, a computer program and a readable medium, and belongs to the technical field of screens. The method includes: receiving a cylindrical lens detection instruction for a target screen, wherein the cylindrical lens detection instruction at least includes target viewpoints; acquiring browsing images shot from the target screen under the target viewpoints in response to the detection instruction, wherein the target screen is a screen of which the light emission side is provided with cylindrical lenses; using the browsing images as viewpoint images under the condition that the browsing images include target contents; and outputting detection parameters of the cylindrical lenses on the target screen based on image parameters of the viewpoint images.

Abstract: This disclosure relates to imidazo[1,2-a]pyridinyl derivatives of formula (I), or pharmaceutically acceptable salts thereof, Formula (I) in which all of the variables are as defined in the specification, capable of modulating the activity of IRAK4. The disclosure further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including inflammatory disease, autoimmune disease, cancer, cardiovascular disease, a disease of the central nervous system, disease of the skin, an ophthalmic disease and condition, and a bone disease.

Abstract: A method and a system for obtaining ecological impact mechanism are provided.

Abstract: A self-powered wireless keyboard by modifying the structure of a traditional membrane keyboard having a volcanic crater structure. Not damaging the original membrane keyboard structure, a micro magnet core is installed inside a cylindrical protrusion block under the key cap as a mover of the induction power generation device, and an induction coil is wound in a key slot of the keyboard base as the stator of the induction power generation device. In this way, when each key is pressed, it will produce induction current. A layer of flexible solar cell can be laid on the upper surface of the key, which can generate electricity by collecting the light energy in the surrounding environment during the time of daily illumination.

Abstract: Techniques for snapshot classification involve generating a plurality of snapshots of a storage system at multiple times; clustering the plurality of snapshots into a first group of snapshots and a second group of snapshots based on data features of the plurality of snapshots; and determining a clean snapshot among the plurality of snapshots based on a comparison between the generation time of the first group of snapshots and the generation time of the second group of snapshots. Accordingly, a clean snapshot and a damaged snapshot can be automatically and quickly distinguished, thereby improving the efficiency of finding a clean snapshot and helping a user recover data quickly.

Abstract: The present disclosure discloses an array substrate and a display device. The array substrate includes a touch substrate, the touch substrate includes a plurality of touch electrodes and a plurality of touch electrode wires disposed in an array, each touch electrode includes a plurality of touch sensors disposed in an array, common electrodes of all pixel cells of the array substrate are reused as the touch sensors, and the array substrate includes data wires for providing display data to the pixel cells; the array substrate includes a base substrate and a thin film transistor which are stacked, the touch electrode wires and the data wires are provided on the same layer where a source and a drain of the thin film transistor are located, and the touch electrode wires are abreast provided on the two sides of each data wire.

Abstract: Disclosed in the present application are a locating method for an uplink time difference of arrival, and an apparatus thereof.

Abstract: A network system includes a first network device, a second network device, and a third network device. The first network device is configured to: obtain a first route advertisement message, where the first route advertisement message includes a first route prefix; and obtain a second route prefix based on the first route prefix, where the second route prefix corresponds to a first network slice, and the second route prefix is a subnet prefix of the first route prefix. The first network device advertises a second route advertisement message to the second network device, where the second route advertisement message includes the second route prefix.

Abstract: A packet sending method and a related device are disclosed. The method includes: A network device obtains a first packet, where an internet protocol extension header of the first packet includes a first identifier, and the first identifier indicates a service requirement corresponding to the first packet. The network device determines, based on the first identifier and a second identifier, path indication information corresponding to the first packet, where a destination address of the first packet includes the second identifier, and the path indication information herein includes one or more of a network slice identifier and a segment identifier list. The network device updates the first packet based on the path indication information to obtain a second packet, and sends the second packet.

Abstract: A simulation system and a method thereof are disclosed. In the simulation system, a system power transmission model, and analog current time-domain model and digital current time-domain model are connected to obtain power noise generated after a supply current is obtained; jitter time-domain information of each interface connection circuit model under the power noise is obtained based on transmission of a clock signal outputted from a phase lock loop, by a simulation program; next, a voltage step response of a voltage measurement point when a clock terminal of each interface connection circuit model receives an ideal signal, is simulated by the simulation program to generate a first voltage time-domain model; a system waveform is generated based on the jitter time-domain information of each interface connection circuit model under the power noise, the first voltage time-domain model and data transmission, thereby obtaining an eye diagram and time-domain jitter distribution.

Abstract: Embodiments of this application provide a packet sending method and a device, to improve packet transmission efficiency. The method includes: A first network device receives a first packet from a second network device, where the first packet includes information about a first forwarding path, and the first forwarding path is a forwarding path for sending the first packet from the second network device to the first network device. The first network device obtains information about a second forwarding path based on the information about the first forwarding path, where the second forwarding path is a reverse path of the first forwarding path. The first network device sends a second packet to the second network device through the second forwarding path, where the second packet carries the information about the second forwarding path.

Abstract: This invention relates to Imidazo[1,2-a]pyridinyl Derivatives of formula (I?), or pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, capable of modulating the activity of IRAK4. The invention further provides a method of manufacturing compounds of the invention, and methods for their therapeutic use. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including inflammatory disease, autoimmune disease, cancer, cardiovascular disease, a disease of the central nervous system, disease of the skin, an ophthalmic disease and condition, and a bone disease.

Abstract: This invention relates to 2H-indazole Derivatives of formula (I?), or pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, capable of modulating the activity of IRAK4. The invention further provides a method of manufacturing compounds of the invention, and methods for their therapeutic use. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including inflammatory disease, autoimmune disease, cancer, cardiovascular disease, a disease of the central nervous system, disease of the skin, an ophthalmic disease and condition, and a bone disease.