Abstract: The present disclosure provides compounds represented by Formula I, or an enantiomer or diastereomer, or a pharmaceutically acceptable salt thereof, wherein X, Y, Z, L, Ar, R1, R2, R3 R4, R5, R6, m, and p are defined herein. Compounds of Formula I are BCR-ABL inhibitors. BCR-ABL inhibitors are useful for the treatment of cancer and other diseases.

Abstract: The present invention relates to an organic semiconducting compound and organic optoelectronic components using the same. The organic semiconducting compound own a novel chemical structure. By using the organic semiconducting compound to prepare organic optoelectronic compounds, environmentally friendly non-halogen solvent can be used. In addition, the photoresponsivity and detectivity are excellent in the near-infrared region.

Abstract: A pyram-shaped deep-sea pressure-resistance shell and a design method therefor. The shell comprises a conical shell, an annular combined shell, a cylindrical shell, a flange bolt, and a perforated thick plate; a bottom end of the conical shell is connected with a top end of the annular combined shell, the conical shell being in communication with an interior part of the annular combined shell; the perforated thick plate blocks the bottom end of the annular combined shell, the perforated thick plate and the annular combined shell being connected by means of multiple flange bolts; the cylindrical shell is disposed inside the annular combined shell, a lower end of the cylindrical shell being inserted in a gap between the annular combined shell and the perforated thick plate.

Abstract: Single cell ribonucleic acid sequencing data has provided numerous avenues to monitor and study organism more thoroughly at a cellular level, including spatial arrangement of cells. An approach to predicting cellular immune response based on cellular spatial features may be presented herein. The approach may include utilizing ribonucleic acid sequence data for a single cell (“scRNA-seq”) or cell from a tissue. The approach may also include extracting spatial features of the single cell using the scRNA-seq data including cell-to-cell interactions and relative distance between cells. The approach may include predicting an immune response of a cell or cells based on the extracted spatial features.

Abstract: This disclosure relates to a method, a system and a computer program product for synthesizing risk prediction models to generate a generalized risk prediction model for a particular disease. The method comprises retrieving a plurality of literatures from one or more databases. Each of the plurality of literatures defines a risk prediction model for a same disease. The method further comprises extracting study features from each of the plurality of literatures. The method further comprises extracting weights of risk factors in the risk prediction model defined by each of the plurality of literatures from the plurality of literatures. The method further comprises calculating adjusted weights of risk factors based on the extracted study features and the extracted weights of risk factors, to form an adjusted risk prediction model.

Abstract: A model learning and sample value generating framework includes a system and method to comprehensively integrate encoding, decoding and value predicting, and optimizing functions to reconstruct as accurate as possible an original input sample data space. The system leverages a variational autoencoder model to generate as realistic samples of that data space as possible. The system learns a value prediction function to achieve a target outcome based on the latent feature data instead of the original input data. Further, the system solves the optimization problem in the latent space without constraints to avoid the difficulty in optimizing in the original sample data space. The generated optimal samples are as similar as possible to the real-world input samples. The system provides a flexible data generation mechanism which is suitable for various kinds of target outcome specifications.

Abstract: In an approach for identifying disease progression hazard ratios for given disease against diseases from an EHR database to determine top comorbidities to the given disease, a processor receives raw EHR data. A processor identifies, from the raw EHR data, a set of diseases and associated diagnosis information for each disease of the set of diseases. A processor calculates a hazard ratio for each disease pair of a set of disease pairs producing a set of hazard ratios, wherein the set of disease pairs comprises a given disease paired with each disease of the set of diseases. A processor ranks the set of hazard ratios for the given disease. A processor selects a pre-defined number of top comorbidities of the set of hazard ratios for the given disease based on the ranking. A processor outputs the pre-defined number of top comorbidities for the given disease.

Abstract: Disclosed herein is a method against coronavirus infection, which includes administering to a subject in need thereof a composition containing a water-extracted product of Perilla frutescens.

Abstract: Disclosed herein is a method against coronavirus infection, which includes administering to a subject in need thereof an effective amount of 6-bromo-2-[1-(2,5-dimethylphenyl)-5-methyl-1H-pyrazol-4-yl]-quinoline-4-carboxylic acid or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed herein is a method against coronavirus infection, which includes administering to a subject in need thereof an effective amount of 8-benzoyl-4-methyl-9-phenyl-furo[2,3-h]chromen-2-one or a pharmaceutically acceptable salt thereof.

Abstract: A blood oxygen detection chip with a capability of fast tracking light intensity. A photocurrent buffer receives light and generates an output photocurrent iph that is not affected by a leakage current as much as possible, a bandgap voltage reference and a linear voltage regulator are mainly used to obtain an accurate adjustable reference voltage Vref, an integrator integrates the photocurrent iph to obtain a voltage signal in a linear relation with a photocurrent value, a pulse generator converts the voltage signal to a frequency signal, and finally an output buffer performs wave shaping to obtain a final output frequency signal Freq in a linear relation with a light intensity value.

Abstract: A direct-acting electromagnetic trip device including a housing, and a regulation mechanism, a linkage mechanism, an electromagnetic system and a trip mechanism which are arranged in the housing. The regulation mechanism is connected with the linkage mechanism, the linkage mechanism is connected with one end of an iron core of the electromagnetic system, and the linkage mechanism is connected with the trip mechanism at the same time. The regulation mechanism includes a rotary knob and a regulation rod, wherein the rotary knob is abutted against and engaged with the regulation rod, and the regulation rod is abutted against and engaged with the linkage mechanism. The electromagnetic system further includes an elastic element that pushes the iron core to allow the linkage mechanism to be abutted against the regulation rod and allow the rotary knob to be abutted against the regulation rod.

Abstract: A pulse modulation circuit with a high-frequency-limiting function, including a comparator, an RS trigger, a switching triode, a NAND gate, a NOR gate, and a charging capacitor. A capacitor charging time is controlled by adjusting a bias current IB1, a bias current IB2, a reference voltage V1, and a reference voltage V2 or adjusting values of capacitors C1 and C2. In this way, a highest output frequency of a pulse generator is limited, so as to reduce hardware system overheads.

Abstract: A low power consumption integrating circuit based on adaptive current regulation, including an amplifier A2, a capacitor Ci, a bias current regulating circuit, where a negative power source terminal of the amplifier A2 is connected to an output terminal of the amplifier A2 through the capacitor Ci, an output of the bias current regulating circuit is connected to an input terminal of the amplifier A2; and the bias current regulating circuit adjusts a bias current according to different light intensity. According to the present invention, the bias current regulating circuit dynamically adjusts, according to light intensity, a bias current input to the amplifier A2, so as to significantly reduce the overall power consumption of the circuit while ensuring a rapid response capability of an optical frequency sensor.

Abstract: A blood oxygen detection chip with a capability of fast tracking light intensity. A photocurrent buffer receives light and generates an output photocurrent iph that is not affected by a leakage current as much as possible, a bandgap voltage reference and a linear voltage regulator are mainly used to obtain an accurate adjustable reference voltage Vref, an integrator integrates the photocurrent iph to obtain a voltage signal in a linear relation with a photocurrent value, a pulse generator converts the voltage signal to a frequency signal, and finally an output buffer performs wave shaping to obtain a final output frequency signal Freq in a linear relation with a light intensity value.

Abstract: The present disclosure relates to a high-speed superjunction lateral insulated gate bipolar transistor, and belongs to the technical field of semiconductor power devices. Fast turn-off can be achieved by replacing the lightly doped substrate of the existing bulk silicon superjunction lateral insulated gate bipolar transistor with heavily doped substrate, breakdown voltage of the device is ensured by reasonably setting the total number of impurities in each drift region of the over junction-sustaining voltage layer, and further application thereof in integrated circuits is realized by providing the semiconductor second substrate region and the semiconductor isolation region. A high speed superjunction laterally insulated gate bipolar transistor according to the present disclosure solves the contradiction between cost of the superjunction laterally insulated gate bipolar transistor and achievement of fast turn-off on a bulk silicon substrate.

Abstract: A pulse modulation circuit with a high-frequency-limiting function, including a comparator, an RS trigger, a switching triode, a NAND gate, a NOR gate, and a charging capacitor. A capacitor charging time is controlled by adjusting a bias current IB1, a bias current IB2, a reference voltage V1, and a reference voltage V2 or adjusting values of capacitors C1 and C2. In this way, a highest output frequency of a pulse generator is limited, so as to reduce hardware system overheads.

Abstract: The present disclosure relates to a high-speed superjunction lateral insulated gate bipolar transistor, and belongs to the technical field of semiconductor power devices. Fast turn-off can be achieved by replacing the lightly doped substrate of the existing bulk silicon superjunction lateral insulated gate bipolar transistor with heavily doped substrate, breakdown voltage of the device is ensured by reasonably setting the total number of impurities in each drift region of the over junction-sustaining voltage layer, and further application thereof in integrated circuits is realized by providing the semiconductor second substrate region and the semiconductor isolation region. A high speed superjunction laterally insulated gate bipolar transistor according to the present disclosure solves the contradiction between cost of the superjunction laterally insulated gate bipolar transistor and achievement of fast turn-off on a bulk silicon substrate.