Patents by Inventor Fanhong Wu

Fanhong Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240350448
    Abstract: Described herein is a dichloroacetic acid conjugating diphenyl ethane compound, and a preparation method and an application thereof. The dichloroacetic acid conjugating diphenyl ethane compound has a stable structure, low toxicity, a simple preparation process and a high yield, without necessity to preserve it in a dark place, and has anti-tumor activity against a variety of tumor cells cultured in vitro, and the anti-tumor effect in vivo.
    Type: Application
    Filed: June 28, 2024
    Publication date: October 24, 2024
    Inventors: Fanhong WU, Jinwen HUANG, Kangyan XUE, Hui NIE, Fuli LIU, Hui TANG
  • Patent number: 11279678
    Abstract: Disclosed is a 5-fluorouracil derivative having the molecular structure shown in general formula VI, in which Ra and Rb groups are an alkoxy group or a fluorine-substituted alkoxy group having 1, 2, 3, or 4 carbon atoms, and are mono-, bis-, tri-, tetra- or penta-substituted on a phenyl group; a linking group L1 is an alkyl or alkenyl group having 1, 2, 3, or 4 carbon atoms, a linking group L2 is oxygen, or an alkyl or alkoxy group having 1, 2, 3, or 4 carbon atoms, or an amino acid, or an alkyl group having 1, 2, 3, or 4 carbon atoms containing an amino moiety, or a furyl group, and an X group is O or —NH—. Further disclosed is a method for preparing such a derivative and a use of the same in the treatment of cancer, tumor diseases, and diseases caused by abnormal neovascularization in a human or non-human mammal, and a medicament or a composition containing the 5-fluorouracil derivative.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: March 22, 2022
    Inventors: Fanhong Wu, Jinwen Huang, Jiujiu Zhou, Wan Pang, Lei Zhao, Zhonglin Ma, Zhikai Zhang, Xiaodong Yu, Jianyue Wu
  • Publication number: 20210230122
    Abstract: Disclosed is a 5-fluorouracil derivative having the molecular structure shown in general formula VI, in which Ra and Rb groups are an alkoxy group or a fluorine-substituted alkoxy group having 1, 2, 3, or 4 carbon atoms, and are mono-, bis-, tri-, tetra- or penta-substituted on a phenyl group; a linking group L1 is an alkyl or alkenyl group having 1, 2, 3, or 4 carbon atoms, a linking group L2 is oxygen, or an alkyl or alkoxy group having 1, 2, 3, or 4 carbon atoms, or an amino acid, or an alkyl group having 1, 2, 3, or 4 carbon atoms containing an amino moiety, or a furyl group, and an X group is O or —NH—. Further disclosed is a method for preparing such a derivative and a use of the same in the treatment of cancer, tumor diseases, and diseases caused by abnormal neovascularization in a human or non-human mammal, and a medicament or a composition containing the 5-fluorouracil derivative.
    Type: Application
    Filed: November 9, 2017
    Publication date: July 29, 2021
    Inventors: Fanhong WU, Jinwen HUANG, Jiujiu ZHOU, Wan PANG, Lei ZHAO, Zhonglin MA, Zhikai ZHANG, Xiaodong YU, Jianyue WU
  • Publication number: 20200163913
    Abstract: The invention discloses CA-4 antitumour drug, their synthetic methods and applications. The CA-4 antitumour drug are obtained by introducing an alkoxy group or a fluorine-containing alkoxy group at the 4? position of the natural product Combretastatin and modified with a functional chemical group at its 3? position. The CA-4 derivated anti-tumor drugs of the invention have inhibitory ability on two targets related to tubulin and arylsulfatase, and can be used for anti-tumor treatment.
    Type: Application
    Filed: July 24, 2018
    Publication date: May 28, 2020
    Inventors: Fanhong Wu, Leilei Huang, Jinwen Huang, Yingzi Li, Da Xie, Meichen Hu
  • Patent number: 8686187
    Abstract: The invention discloses an ethoxydiphenylethane derivative and a synthetic method and uses thereof 4? position of phenylethane B aromatic ring is chemically modified by ethoxy and hydroxy at position 3? thereof is simultaneously modified to water soluble prodrug such as phosphate, and similarly, amino acid side chain is introduced to amino at position 3? to form amino acid amide water soluble prodrug having the structure shown as formula (I) the ethoxydiphenylethane derivative and the prodrug thereof include strong tubulin aggregation inhibiting ability and obvious target damage effect for tumor vessels, selectively cause dysfunction and structural damage of tumor vessels and induce apoptosis of vascular endothelial cells in order to play the role of killing tumor cells or inhibiting tumor metastasis in case that the tumor cells are free from the support of nutrition and oxygen.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: April 1, 2014
    Assignees: Shanghai Ecust Biomedicine Co., Ltd., Zhejiang Wild Wind Pharmaceutical Co. Ltd.
    Inventors: Fanhong Wu, Fanhua Xiao, Weiguo Zhou, Fangming Xu
  • Publication number: 20120046492
    Abstract: The invention discloses an ethoxydiphenylethane derivative and a synthetic method and uses thereof 4? position of phenylethane B aromatic ring is chemically modified by ethoxy and hydroxy at position 3? thereof is simultaneously modified to water soluble prodrug such as phosphate, and similarly, amino acid side chain is introduced to amino at position 3? to form amino acid amide water soluble prodrug having the structure shown as formula (I) the ethoxydiphenylethane derivative and the prodrug thereof include strong tubulin aggregation inhibiting ability and obvious target damage effect for tumor vessels, selectively cause dysfunction and structural damage of tumor vessels and induce apoptosis of vascular endothelial cells in order to play the role of killing tumor cells or inhibiting tumor metastasis in case that the tumor cells are free from the support of nutrition and oxygen.
    Type: Application
    Filed: October 15, 2009
    Publication date: February 23, 2012
    Applicants: Zhejiang Wild Wind Pharmaceutical Co., Ltd., Shanghai Ecust Biomedicine Co.Ltd.
    Inventors: Fanhong Wu, Fanhua Xiao, Weiguo Zhou, Fangming Xu