Abstract: The invention discloses a model based on machine learning-radiomics which is a Nomogram model; the establishment of said Nomogram model comprising following steps: S1. collecting data and predicting factor selection; S2. combining selected 6 radiomics characteristics according to contribution weighting, developing a rad-score model; S3. establishing different diagnosis models, comparing performances of the diagnosis models in the diagnosis of osteoporosis and osteopenia, wherein said diagnosis models comprise: Clinics model, Radiomics model, and Combined model; S4. performing visualization processing on combined model by using the “rms” packet in R software to obtain Nomogram model; S5. validation of the Nomogram model. The invention combines characteristics of the radiomics and clinical risk factors to establish a combined Nomogram model to diagnose conditions of osteoporosis and osteopenia of patients.

Abstract: A dual-modality nanoprobe targeting glioblastoma and preparation method thereof are described. The dual-modality nanoprobe of the present disclosure comprises DSPE-PEG(2000)-Amine, superparamagnetic iron oxide nanoparticles (SPIONs), Cy7-NHS molecule, targeting polypeptide and/or trans-mirror structure (i.e., enantiomer) thereof. The dual-modality nanoprobe can integrate the advantages of magnetic resonance and fluorescence imaging and thus provide clearer anatomical structure information of brain tumors; in the imaging process, the dual-modality nanoprobe can not only provide clearer image results, but also can specifically identify target sites. Also, the dual-modality nanoprobe of the present disclosure also has good in vivo stability.

Abstract: A pressurized decanting device decants wine, so that oxidation is prevented by not agitating the wine as it decants, or agitating solid matter resting on the bottom of bottle. The decanting device couples to the mouth of bottle through a cork having a cork borehole. A pump forces pressurized gas into the bottle of wine. The consequential pressure forces the wine out of the bottle through a discharge pipe in the housing. The device includes a base mounted with a housing. The housing includes an outlet apparatus, a pump, a power supply mechanism, and a switch mechanism operatively connected to the pump and the power supply mechanism. An outlet pipe and a gas guiding apparatus extend from the outlet apparatus. The switch mechanism mounts on the outlet apparatus through power supply mechanism. The outlet apparatus controls a liquid and a gas to discharge or stop discharging from outlet pipe.

Abstract: A pressurized decanting device decants wine, so that oxidation is prevented by not agitating the wine as it decants, or agitating solid matter resting on the bottom of bottle. The decanting device couples to the mouth of bottle through a cork having a cork borehole. A pump forces pressurized gas into the bottle of wine. The consequential pressure forces the wine out of the bottle through a discharge pipe in the housing. The device includes a base mounted with a housing. The housing includes an outlet apparatus, a pump, a power supply mechanism, and a switch mechanism operatively connected to the pump and the power supply mechanism. An outlet pipe and a gas guiding apparatus extend from the outlet apparatus. The switch mechanism mounts on the outlet apparatus through power supply mechanism The outlet apparatus controls a liquid and a gas to discharge or stop discharging from outlet pipe.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel quinazoline derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel quinazoline derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel quinazoline derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: Disclosed are a method and electronic device for controlling reporting of crash data, wherein the method includes: configuring a data filtering list according to control parameters; sending the data filtering list to the client, and instructing the client to filter crash data according to the data filtering list; and receiving the crash data filtered according to the data filtering list and reported by the client. According to the method, the server configures the data filtering list, and then the client can determine requirements for reporting the current crash data according to the data filtering list, so that the crash data more in line with the needs of the server are reported, and the method can be applicable to the case of system version update.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: Provided are certain dipeptidyl peptidase inhibitors, pharmaceutical compositions thereof, and methods of use therefor.