Abstract: A controlled release device useful for the release of vapors or liquids to the surrounding of the user is described. The device is a multilayered laminate consisting of a reservoir layer which incorporates an active compound, such as a nasally delivered therapeutic medication or insect repellant, an impermeable membrane layer adjacent the reservoir layer and a diffusion rate limiting membrane layer adjacent the reservoir layer. The device preferably includes an adhesive layer for adhering the device to skin or a surface and an ornamental decorative layer.

Abstract: A controlled release device useful for the release of vapors or liquids is described. The device is a multilayered laminate consisting of a reservoir layer which incorporates an active compound, such as a perfume or fragrance or insect repellant, an impermeable membrane layer adjacent the reservoir layer and a diffusion rate limiting membrane layer adjacent the reservoir layer. The device preferably includes an adhesive layer for adhering the device to skin or a surface and an ornamental decorative layer.

Abstract: A controlled release system using a feedback-responsive controller reversibly changes the pH of the aqueous microenvironment of a biologically active compound sequestered in an aqueous-fluid-penetrable, aqueous-insoluble biocompatible material; the pH change is effected in response to a change in the concentration of the target compound in the aqueous medium surrounding the insoluble material; as a result of the pH change, the aqueous solubility and therefore the release rate of the active compound is reversibly changed.