Patents by Inventor Federico Arcamone
Federico Arcamone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20060067997Abstract: Pharmaceutical formulations constituted by a lexitropsin phospholipidic complex in the form of liposomes, micelles or nanoparticles exhibit optimal pharmacological properties in respect to other formulations containing active principles belonging to the same chemical class in both the topical or parenteral treatment of infectious and/or tumour diseases.Type: ApplicationFiled: June 26, 2003Publication date: March 30, 2006Inventors: Federico Arcamone, Ugo Citernesi
-
Patent number: 6160102Abstract: The present invention refers to conjugates formed by a natural or modified oligonucleotide, capable of forming a triple helix with a DNA chain, linked to the aglycone moiety of an anthracycline or to an anthracyclinone via an appropriated linker; such conjugates are capable to bind selectively to specific DNA regions inhibiting their transcription and therefore the formation of the corresponding codified protein.Type: GrantFiled: September 9, 1998Date of Patent: December 12, 2000Assignee: Consiglio Nazionale Delle RicercheInventors: Anna Maria Garbesi, Stefania Bonazzi, Stefania Zanella, Massimo Luigi Capobianco, Giuseppe Giannini, Federico Arcamone
-
Patent number: 6150325Abstract: This invention relates to novel compounds of general formula (I): ##STR1## and to pharmaceutical compositions containing them.Type: GrantFiled: September 9, 1997Date of Patent: November 21, 2000Assignee: A. Menarini Industrie Farmaceutiche Riunite S.r.l.Inventors: Federico Arcamone, Carlo Alberto Maggi, Laura Quartara, Danilo Giannotti
-
Patent number: 5849795Abstract: The present invention refers to tachykinins antagonists of general formula (I) ##STR1## their preparation and pharmaceutical compositions containing them.Type: GrantFiled: September 9, 1997Date of Patent: December 15, 1998Assignee: A Menarini Industrie Farmaceutiche Riunite S.r.l.Inventors: Alessandro Sisto, Edoardo Potier, Stefano Manzini, Christopher Fincham, Paolo Lombardi, Federico Arcamone
-
Patent number: 5814608Abstract: 8-fluoro-anthracyclines of formula (I) have anti-tumor activity. ##STR1## wherein: R is chosen in the group consisting of H, OH, OR.sub.4 wherein R.sub.4 is chosen in the group consisting of CHO, COCH.sub.3, acyl derivative of a carboxylic acid containing up to 6 carbon atoms;R.sub.1 is chosen in the group consisting of: H, OH, OCH.sub.3 ;R.sub.2 is chosen in the group consisting of: H, OH, NH.sub.2R.sub.3 is chosen in the group consisting of: H, OH, NH.sub.2, residue of formula (A) ##STR2## The compounds are characterized by having cis-stereochemistry between the groups 8--F and 9--OH. Their preparation and pharmaceutical compositions containing them are also described.Type: GrantFiled: April 21, 1997Date of Patent: September 29, 1998Assignees: Bristol-Myers Squibb, S.p.A., A. Menarini Industrie Farmaceutiche Riunite S.R.L.Inventors: Fabio Animati, Federico Arcamone, Giuseppe Giannini, Paolo Lombardi, Edith Monteagudo
-
Patent number: 5807835Abstract: New 8-fluoroanthracycline derivatives of formula I possessing antitumoral properties are described, together with their preparation and pharmaceutical compositions containing them.Type: GrantFiled: May 14, 1991Date of Patent: September 15, 1998Assignee: A. Menarini Industrie Farmaceutiche Riunite S.r.l.Inventors: Fabio Animati, Paolo Lombardi, Federico Arcamone
-
Patent number: 5760248Abstract: A description is given of tachykinin receptor antagonists having general formula (I) ##STR1## their preparation and use in pharmaceutical formulations.Type: GrantFiled: May 31, 1996Date of Patent: June 2, 1998Assignee: A.Menarini Industrie Farmaceutiche Riunite S.r.l.Inventors: Alessandro Sisto, Christopher Fincham, Edoardo Potier, Stefano Manzini, Federico Arcamone, Paolo Lombardi
-
Patent number: 5698710Abstract: The present invention refers to tachykinins antagonists of general formula (I) ##STR1## their preparation and pharmaceutical compositions containing them.Type: GrantFiled: July 8, 1996Date of Patent: December 16, 1997Assignee: A. Menarini Industrie Farmaceutiche Riunite S.r.l.Inventors: Alessandro Sisto, Edoardo Potier, Stefano Manzini, Christopher Fincham, Paolo Lombardi, Federico Arcamone
-
Patent number: 5670534Abstract: The present invention relates to Distamycin compounds of formula (I), methods of use and their pharmaceutical compositions.Type: GrantFiled: February 16, 1996Date of Patent: September 23, 1997Assignees: A. Menarini Industrie Farmaceutice Reunite S.R.L., Bristol Myers Squibb S.P.A.Inventors: Fabio Animati, Federico Arcamone, Paolo Lombardi, Cristina Rossi
-
Patent number: 5641802Abstract: A description is given of tachyquinine antagonists having general formula (I) ##STR1## their preparation and use in pharmaceutical formulations.Type: GrantFiled: June 2, 1995Date of Patent: June 24, 1997Assignees: A. Menarini Industrie Farmaceutiche Reiunite S.r.l., Malesci Istituto Farmacobiologico S.p.A.Inventors: Federico Arcamone, Paolo Lombardi, Stefano Manzini, Edoardo Potier, Alessandro Sisto
-
Patent number: 5472976Abstract: This invention relates to polyaminopyrrolecarboxyamide derivatives of general formula (I) and their pharmaceutically acceptable salts, in which A represents a chemical bond or an aromatic or heteroaromatic radical, and:if A is a chemical bond, R is hydrogen, alkyl, dialkylaminoalkyl, alkenyl, cycloalkyl, arylalkyl, arylalkenyl, haloalkyl, or an aromatic or heteroaromatic radical;whereas if A is an aromatic or heteroaromatic radical, R is nitro, amino or formylamino;n is 0 or a whole number between 1 and 4;Z is an alkylene or aromatic radical.Type: GrantFiled: August 6, 1993Date of Patent: December 5, 1995Assignees: A. Menarini Industrie Farmaceutiche Riunite S.r.l., Bristol-Meyers Squibb S.p.A.Inventors: Fabio Animati, Federico Arcamone, Giuseppe Giannini, Paolo Lombardi
-
Patent number: 5310752Abstract: The invention relates to distamycin A analogs of the following formula ##STR1## wherein n is 2, 3 or 4; A is an optionally substituted divalent radical chosen from ##STR2## and --Het-- wherein Het is a pentatomic or hexatomic heteromonocyclic ring, except pyrrole; and wherein either one of R.sub.1 and R.sub.2 is hydrogen and the other is an acylating moiety or R.sub.1 and R.sub.2 are both hydrogen or both alkyl groups optionally substituted, including the pharmaceutically acceptable salts of the said compounds.The compounds of the invention can be useful antitumor and antiviral agents.Type: GrantFiled: August 10, 1992Date of Patent: May 10, 1994Assignee: Farmitalia Carlo Erba SpAInventors: Ettore Lazzari, Federico Arcamone, Sergio Penco, Maria A. Verini, Nicola Mongelli
-
Patent number: 5138042Abstract: Anthracycline glycosides useful as antitumor agents of formula XV: ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxy group, one of R.sub.2 and R.sub.3 represents a hydrogen atom, the other of R.sub.2 and R.sub.3 represents a hydrogen atom or a hydroxy group and X is a hydrogen atom or a trifluoro acetyl group.Type: GrantFiled: March 28, 1990Date of Patent: August 11, 1992Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Francesco Angelucci, Sergio Penco, Ermes Vanotti, Federico Arcamone
-
Patent number: 5049579Abstract: The invention relates to distamycin A analogs of the following formula ##STR1## wherein n is 2, 3 or 4; A is an optionally substituted divalent radical chosen from ##STR2## and -Het- wherein Het is a pentatomic or hexatomic heteromonocyclic ring, except pyrrole; and wherein either one of R.sub.1 and R.sub.2 is hydrogen and the other is an acylating moiety or R.sub.1 and R.sub.2 are both hydrogen or both alkyl groups optionally substituted, including the pharmaceutically acceptable salts of the said compounds.The compounds of the invention can be useful antitumor and antiviral agents.Type: GrantFiled: October 31, 1990Date of Patent: September 17, 1991Assignee: Farmitalia Carlo Erba, S.r.l.Inventors: Ettore Lazzari, Federico Arcamone, Sergio Penco, Maria A. Verini, Nicola Mongelli
-
Patent number: 5037970Abstract: A compound of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxy group, one of R.sub.2 and R.sub.3 represents a hydrogen atom, the other of R.sub.2 and R.sub.3 represents a hydrogen atom or a hydroxy group and X is a hydrogen atom or a trifluoro acetyl group. The N-trifluoroacetyl 7S:9S and 7R:9R derivatives of the .alpha.-glycosides of formula XV can be separated by chromatography on silica gel to obtain, after mild alkaline hydrolysis the wanted 7S:9S .alpha.-glycosides (R.sub.1 =H) as free bases and can eventually be transformed into their corresponding doxorubicin derivatives (R.sub.1 =OH) by known procedures.Type: GrantFiled: March 28, 1990Date of Patent: August 6, 1991Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Francesco Angelucci, Sergio Penco, Ermes Vanotti, Federico Arcamone
-
Patent number: 5017599Abstract: The invention relates to distamycin A analogs of the following formula ##STR1## wherein n is 2, 3 or 4; A is an optionally substituted divalent radical chosen from ##STR2## and -Het- wherein Het is a pentatomic or hexatomic heteromonocyclic ring, except pyrrole; and wherein either one of R.sub.1 and R.sub.2 is hydrogen and the other is an acylating moiety or R.sub.1 and R.sub.2 are both hydrogen or both alkyl groups optionally substituted, including the pharmaceutically acceptable salts of the said compounds.The compounds of the invention can be useful antitumor and antiviral agents.Type: GrantFiled: February 21, 1990Date of Patent: May 21, 1991Assignee: Farmitalia Carlo Erba, SpAInventors: Ettore Lazzari, Federico Arcamone, Sergio Penco, Maria A. Verini, Nicola Mongelli
-
Patent number: 4985548Abstract: Anthracycline glycosides of the general formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxyl group, one of R.sub.2 and R.sub.3 represents a hydrogen atom and the other of R.sub.2 and R.sub.3 represents a hydrogen atom or a hydroxyl group; and pharmaceutically acceptable acid addition salts thereof are antitumor agents. These glycosides may be prepared from a daunomycinone derivative of formula (II): ##STR2## in which the 4-amino group is protected. 4-Demethoxy-4-amino-daunomycinone (II) and an earlier intermediate in its preparation, 4-demethoxy-4-amino-7-deoxy-daunomycinone (IX), can be diazotised followed by mild reduction to form 4-demethoxy-daunomycinone or 4-demethoxy-7-deoxy-daunomycinone respectively. 4-Demethoxy-daunomycinone can be converted into another antitumor anthracycline glycoside, 4-demethoxy-daunorubicin.Type: GrantFiled: January 9, 1990Date of Patent: January 15, 1991Assignee: Farmitalia Carlo Erba S.R.L.Inventors: Michele Caruso, Antonino Suarato, Francesco Angelucci, Federico Arcamone
-
Patent number: 4965351Abstract: Anthracycline glycosides of the general formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxyl group, one of R.sub.2 and R.sub.3 represents a hydrogen atom and the other of R.sub.2 and R.sub.3 represents a hydrogen atom or a hydroxyl group; and pharmaceutically acceptable acid addition salts thereof are antitumor agents. These glycosides may be prepared from a daunomycinone derivative of formula (II): ##STR2## in which the 4-amino group is protected. 4-Demethoxy-4-amino-daunomycinone (II) and an earlier intermediate in its preparation, 4-demethoxy-4-amino-7-deoxy-daunomycinone (IX), can be diazotized followed by mild reduction to form 4-demethoxy-daunomycinone or 4-demethoxy-7-deoxy-daunomycinone respectively. 4-Demethoxy-daunomycinone can be converted into another antitumor anthracycline glycoside, 4-demethoxy-daunorubicin.Type: GrantFiled: November 1, 1989Date of Patent: October 23, 1990Assignee: Farmitalia Carlo Erba S.R.L.Inventors: Michele Caruso, Antonino Suarato, Francesco Angelucci, Federico Arcamone
-
Patent number: 4939282Abstract: A new process for the preparation of 6-deoxyanthracyclinones of general formula I: ##STR1## wherein R represents a hydrogen atom, a hydroxy group or a lower alkoxy group is described. The process provides a total synthesis of the 6-deoxyanthracyclinones of formula I using 1,2,3,6-tetrahydro-phthalate as starting material. The obtained racemic mixture of the compounds of formula I, if desired, can be submitted to optical resolution by the conventional method of conversion to diastereomeric derivatives using a chiral resolving agent. Alternatively, the racemic mixture can be used as such for the condensation with a suitably protected halosugar derivative to obtain alpha glycosidic derivatives of formula XV: ##STR2## wherein R.sub.1 represents a hydrogen atom or a hydroxy group, one of R.sub.2 and R.sub.3 represents a hydrogen atom, the other of R.sub.2 and R.sub.3 represents a hydrogen atom or a hydroxy group and X is a hydrogen atom or a trifluoro acetyl group.Type: GrantFiled: June 19, 1984Date of Patent: July 3, 1990Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Francesco Angelucci, Sergio Penco, Ermes Vanotti, Federico Arcamone
-
Patent number: 4906743Abstract: Anthracycline glycosides of the general formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxyl group, one of R.sub.2 and R.sub.3 represents a hydrogen atom and the other of R.sub.2 and R.sub.3 represents a hydrogen atom or a hydroxyl group; and pharmaceutically acceptable acid addition salts thereof are antitumor agents. These glycosides may be prepared from a daunomycinone derivative of formula (II): ##STR2## in which the 4-amino group is protected. 4-Demethoxy-4-amino-daunomycinone (II) and an earlier intermediate in its preparation, 4-demethoxy-4-amino-7-deoxy-daunomycinone (IX), can be diazotized followed by mild reduction to form 4-demethoxy-daunomycinone or 4-demethoxy-7-deoxy-daunomycinone respectively. 4-Demethoxy-daunomycinone can be converted into another antitumor anthracycline glycoside, 4-demethoxy-daunorubicin.Type: GrantFiled: April 14, 1988Date of Patent: March 6, 1990Assignee: Farmitalia Carlo Erba S.R.L.Inventors: Michele Caruso, Antonino Suarato, Francesco Angelucci, Federico Arcamone