Abstract: The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme.

Abstract: The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors with additional functional domains. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: The present application provides a method for removing a metal from a metal-containing solution, comprising contacting a legume product with the metal-containing solution; and removing the legume product from the solution.

Abstract: Multistage RF transmitter and receiver circuits may use independently variable RF and IF local oscillators, allowing the RF and IF local oscillator frequencies for a given RF channel to be selected to have a large common factor with respect to the reference oscillator used by the local oscillator circuits, thus allowing the use of small divisor numbers in the local oscillator circuits and reducing phase noise. Independent high-side and low-side RF local oscillators may be provided and selectively used depending on the RF channel to be transmitted or received.

Abstract: Multistage RF transmitter and receiver circuits may use independently variable RF and IF local oscillators, allowing the RF and IF local oscillator frequencies for a given RF channel to be selected to have a large common factor with respect to the reference oscillator used by the local oscillator circuits, thus allowing the use of small divisor numbers in the local oscillator circuits and reducing phase noise. Independent high-side and low-side RF local oscillators may be provided and selectively used depending on the RF channel to be transmitted or received.

Abstract: Multistage RF transmitter and receiver circuits may use independently variable RF and IF local oscillators, allowing the RF and IF local oscillator frequencies for a given RF channel to be selected to have a large common factor with respect to the reference oscillator used by the local oscillator circuits, thus allowing the use of small divisor numbers in the local oscillator circuits and reducing phase noise. Independent high-side and low-side RF local oscillators may be provided and selectively used depending on the RF channel to be transmitted or received.

Abstract: A low-profile cavity-backed slot antenna is disclosed including a cavity substrate having a slot with a resonant frequency and a uniplanar compact photonic band-gap (UC-PBG) substrate, proximate to the cavity substrate and having a two-dimensional periodic metallic pattern on a dielectric slab and a ground plane, wherein the UC-PBG substrate behaves substantially as an open boundary at the resonant frequency of the slot. The slot antenna has reduced height while maintaining good performance.

Abstract: A low-profile cavity-backed slot antenna is disclosed including a cavity substrate having a slot with a resonant frequency and a unilanar compact photonic band-gap (UC-PBG) substrate proximate to the cavity substrate and having a two-dimensional periodic metallic pattern on a dielectric slab and a ground plane, wherein the UC-PBG substrate behaves substantially as an open boundary at the resonant frequency of the slot. The slot antenna has reduced height while maintaining good performance.