Abstract: This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.

Abstract: A high temperature-resistant wheel, comprising: an elastic hub assembly (1), which has a thermal insulation layer integrated therewith so as to insulate the elastic hub assembly (1) from exterior high temperatures; and a rigid wheel barbed ring (2), which has the elastic hub assembly (1) fastened inside and rotates together with the elastic hub assembly (1). A robot, which comprises the high temperature-resistant wheel.

Abstract: The present invention relates to a crystal of cephalosporin intermediate 7?-methoxy cephalothin (I) and a method for preparing same. The crystal of 7?-methoxy cephalothin (I) undergoes Cu-Ka radiation and X-ray powder diffraction expressed in terms of angle 2?; the crystal of 7?-methoxy cephalothin (I) has characteristic absorption peaks at positions of 7.34°±0.20°, 12.71°±0.20°, 14.25°±0.20°, 14.68°±0.20°, 16.52°±0.20°, 17.99°±0.20°, 19.98°±0.20°, and 22.69°±0.20°. The crystal of 7?-methoxy cephalothin provided by the present invention is easy to prepare. Related test data shows that the crystal of 7?-methoxy cephalothin has high purity, low impurity content, and good stability. The preparation cost is low, the preparation method is simple to operate, conditions are mild and easy to control, and crystals of 7?-methoxy cephalothin can be obtained stably. The invention is applicable to industrial production.

Abstract: The present invention relates to compositions of anti-CTLA-4 antibodies that bind to the human CTLA4 molecule and their use in cancer immunotherapy and for the reduction of autoimmune side effects compared to other immunotherapeutic agents.

Abstract: This invention relates to anti-CTLA-4 antibody compositions that bind to the human CTLA-4 molecule, and the use of the compositions in cancer immunotherapy and for reducing autoimmune side effects compared to other immunotherapeutic agents.

Abstract: A 25-hydroxycholecalciferol monohydrate crystal, a preparation method thereof, and a microemulsion using the 25-hydroxycholecalciferol monohydrate crystal. The X-ray powder diffraction spectrum of the 25-hydroxycholecalciferol monohydrate crystal of the present disclosure shows characteristic peaks at 2? of 10.035°, 11.623°, 14.631°, 15.054°, 15.551°, 16.471°, 17.198°, 19.002°, 19.628°, 20.109°, 21.886°, 23.113°, 23.661°, 24.701°, 25.220°, 25.440°, and 28.527°. The 25-hydroxycholecalciferol monohydrate crystal can effectively enhance the stability of 25-hydroxycholecalciferol, and is more beneficial to the production and storage of related preparations, and thus biological characteristics of 25-hydroxycholecalciferol can be effectively utilized.

Abstract: The present invention discloses a universal non-invasive blood glucose estimation method based on time series analysis, which comprises 5 steps, i.e., data input and preprocessing, features screening, establishment of single-feature model based on time series analysis, multi-feature fusion, and non-invasive blood glucose estimation. During non-invasive blood glucose estimation, new non-invasive test data is inputted, and the blood glucose estimation series is calculated using related feature information obtained through modeling, single-feature model, and multi-feature fusion model. The estimation method provided in the present invention is easy to execute, and can overcome the delay between changes of physiological parameters of human body and changes of blood glucose, and thereby can obtain more accurate non-invasive blood glucose test results. The estimation method is universal and is applicable to different non-invasive blood glucose monitoring methods.

Abstract: A multi-sensor non-invasive blood glucose monitoring instrument based on impedance spectroscopy-optical method, which belongs to a blood glucose measuring instrument for human body. The blood glucose monitoring instrument comprises a detection probe, a microprocessor, a display unit and a storage unit. The detection probe comprises a temperature and humidity sensor, an LED array, a photoelectric sensor, a pair of low-frequency electrodes, and a pair of high-frequency electrodes. The high-frequency electrode employs parallel electrodes, a matching inductor is directly soldered to the positive electrode or negative electrode of the electrode, and a shielding electrode is provided around the high-frequency electrode. The distance between the two low-frequency electrodes is 1 cm-2 m, and the low-frequency electrodes can test the low-frequency impedance of the tissue stably.

Abstract: The present invention relates to a crystal of cephalosporin intermediate 7?-methoxy cephalothin (I) and a method for preparing same. The crystal of 7?-methoxy cephalothin (I) undergoes Cu-Ka radiation and X-ray powder diffraction expressed in terms of angle 2?; the crystal of 7?-methoxy cephalothin (I) has characteristic absorption peaks at positions of 7.34°±0.20°, 12.71°±0.20°, 14.25°±0.20°, 14.68°±0.20°, 16.52°±0.20°, 17.99°±0.20°, 19.98°±0.20°, and 22.69°±0.20°. The crystal of 7?-methoxy cephalothin provided by the present invention is easy to prepare. Related test data shows that the crystal of 7?-methoxy cephalothin has high purity, low impurity content, and good stability. The preparation cost is low, the preparation method is simple to operate, conditions are mild and easy to control, and crystals of 7?-methoxy cephalothin can be obtained stably. The invention is applicable to industrial production.

Abstract: The present invention discloses a universal non-invasive blood glucose estimation method based on time series analysis, which comprises 5 steps, i.e., data input and preprocessing, features screening, establishment of single-feature model based on time series analysis, multi-feature fusion, and non-invasive blood glucose estimation. During non-invasive blood glucose estimation, new non-invasive test data is inputted, and the blood glucose estimation series is calculated using related feature information obtained through modeling, single-feature model, and multi-feature fusion model. The estimation method provided in the present invention is easy to execute, and can overcome the delay between changes of physiological parameters of human body and changes of blood glucose, and thereby can obtain more accurate non-invasive blood glucose test results. The estimation method is universal and is applicable to different non-invasive blood glucose monitoring methods.

Abstract: This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.

Abstract: A multi-sensor non-invasive blood glucose monitoring instrument based on impedance spectroscopy-optical method, which belongs to a blood glucose measuring instrument for human body. The blood glucose monitoring instrument comprises a detection probe, a microprocessor, a display unit and a storage unit. The detection probe comprises a temperature and humidity sensor, an LED array, a photoelectric sensor, a pair of low-frequency electrodes, and a pair of high-frequency electrodes. The high-frequency electrode employs parallel electrodes, a matching inductor is directly soldered to the positive electrode or negative electrode of the electrode, and a shielding electrode is provided around the high-frequency electrode. The distance between the two low-frequency electrodes is 1 cm-2 m, and the low-frequency electrodes can test the low-frequency impedance of the tissue stably.

Abstract: A compressed air distributor which is mounted on a spray gun, comprising: a compressed air inlet pipe disposed within a spray gun body, an annular gas supply pipe, an adjustment screw plug, a screw, an adjustment nut, an adjustment knob, a groove, and an adjustment through hole; wherein the center line of the adjustment through hole is eccentrically disposed on the axis line of the adjustment screw plug; wherein the bottom surface of the adjustment screw plug is coupled to an enclosed base having a connecting passage communicating with the annular gas supply pipe; when the adjustment screw plug is rotated, the adjustment through hole can be communicated with the connecting passage or sealed by the enclosed base. The compressed air distributor has a simple structure, low manufacturing cost, and is able to flexibly adjust the size of the spraying flow.

Abstract: A sealing structure of a plunger pump, comprising: a pump body and a plunger rod assembly disposed in the pump body; wherein the pump body includes an upper pump and a lower pump, and the upper pump and lower pump are fixed by screw connection; a sealing ring provided between the upper pump and the lower pump; wherein the plunger rod assembly includes an annular groove disposed at a position adjacent to a lower portion of the plunger rod at an outer peripheral surface thereof; a dynamic lip seal fitted in the annular groove; and a static lip seal sleeved on the outer peripheral surface of the plunger rod; the sealing structure of the plunger pump has good sealing effect, good anti-wear and anti-wear effect, simple replacement and low maintenance cost.

Abstract: A bacterial strain of Actinoplanes sp. and and the use thereof. The bacterial strain is named Actinoplanes sp. HS-16-20, whose preservation number is CGMCC (China General Microbiological Culture Collection Center) No. 7294. The bacterial strain can be used to generate Fidaxomicin or analogs thereof or compositions containing Fidaxomicin, such as by aerobically fermenting the strain in nutrient medium containing assimilable carbon and/or nitrogen sources. Fidaxomicin has an inhibitory effect on various gram positive bacteria pathogens, and in particular, on Clostridium difficile.

Abstract: A unidirectionally bendable transmission chain. At a first side thereof, an inner stop plate is fixed between a pair of inner chain plates at both ends of pin shafts, and an outer stop plate is fixed between a pair of outer chain plates at both ends of the pin shafts. Both ends of the inner stop plate are flush with axes of pin holes provided at both ends of the inner chain plates, and both ends of the outer stop plate are respectively provided with extensions beyond the outer chain plates; the extensions of the outer stop plate form a one-sided support for the inner stop plate to prevent the transmission chain from bending toward the first side, thus the transmission chain bends unidirectionally toward a second side opposite to the first side. A hoisting mechanism and a liftable roadblock having the above transmission chain.

Abstract: This invention relates to a navigation system for integrating a number of positioning receivers to obtain a final position. The navigation system comprises an operation and control module and a unifying module. The operation and control module is being configured to receive a location data from each of the positioning receivers and transmits the location data to the unifying module. The unifying module will then determine the final position based on a statistical model. In particular, the statistical model uses normal distribution to determine the final position. This final position is then displayed on the display of the navigation system.

Abstract: A unidirectionally bendable transmission chain is provided. At a first side thereof, an inner stop plate is fixed between a pair of inner chain plates at both ends of pin shafts, and an outer stop plate is fixed between a pair of outer chain plates at both ends of the pin shafts. Both ends of the inner stop plate are flush with axes of pin holes provided at both ends of the inner chain plates, and both ends of the outer stop plate are respectively provided with extensions beyond the outer chain plates; the extensions of the outer stop plate form a one-sided support for the inner stop plate to prevent the transmission chain from bending toward the first side, thus the transmission chain bends unidirectionally toward a second side opposite to the first side. A hoisting mechanism and a liftable roadblock having the above transmission chain are further provided.

Abstract: This invention relates to a navigation system for integrating a number of positioning receivers to obtain a final position. The navigation system comprises an operation and control module and a unifying module. The operation and control module is being configured to receive a location data from each of the positioning receivers and transmits the location data to the unifying module. The unifying module will then determine the final position based on a statistical model. In particular, the statistical model uses normal distribution to determine the final position. This final position is then displayed on the display of the navigation system.

Abstract: A GaN based LED epitaxial structure and a method for manufacturing the same. The GaN based LED epitaxial structure may include: a substrate; and a GaN based LED epitaxial structure grown on the substrate, wherein the substrate is a substrate containing a photoluminescence fluorescent material. The photoelectric efficiency of the LED epitaxial structure is enhanced and the amount of heat generated from a device is reduced by utilizing a rare earth element doped Re3Al5O12 substrate; since the LED epitaxial structure takes a fluorescence material as a substrate, a direct white light emission may be implemented by such an LED chip manufactured by the epitaxial structure, so as to simplify the manufacturing procedure of the white light LED light source and to reduce production cost. The defect density of the epitaxial structure is reduced by firstly epitaxial growing, patterning the substrate and then laterally growing a GaN based epitaxial structure.