Abstract: Provided are proteins comprising a PD-L1-binding moiety linked to a TGF?-binding moiety, IL-1-binding moiety, immunostimulatory polypeptides (e.g., soluble LAG3 or soluble CD4) or CD47-binding moiety, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same and the uses thereof.

Abstract: An LADCP and combined inertial navigation system combined observation system and method. The system includes an LADCP, combined inertial navigation system host, data processing unit, wireless transmission module, voltage-resistant wireless antenna, battery cabin, first and second GNSS antennae and an instrument support. The data processing unit is connected to the LADCP and the system host through serial ports to obtain ocean current profile measurement data, a GNSS position, GNSS orientation data, three-axis acceleration data, a three-axis gyroscope angular velocity, a roll angle, a pitch angle and a course angular rate. Real-time high-precision correction is performed on a three-dimensional flow velocity of an ocean current profile observed by the LADCP based on the orientation data, roll angle, pitch angle and the course angular rate. Accordingly, measurement precision of flow velocity and flow direction by the LADCP is improved, and working costs to carry out profile flow observation are reduced.

Abstract: A plastic material is useful as an ink receiver or printing medium in dye diffusion thermal transfer printing, wherein the plastic material has a polyamide component (a), and a (co)-polyamide (b) based on ether units and amide units. This plastic material can be used to make a layered structure. The layered structure can be used in dye diffusion thermal transfer printing. A security and/or valuable document with the layered structure can be obtained. Based on the finding that the (co)-polyamide (h) offers sufficient absorbency for the printing ink, the layer produced from the plastic material can be printed on by means of dye diffusion thermal transfer printing with a good color intensity.

Abstract: Provided are engineered split Cas12b systems and methods of use thereof. Also provided are compositions comprising one or more components of the engineered split Cas12b systems, as well as engineered cells and non-human animals produced by the methods. The systems, methods and compositions are useful for genome editing, transcription modulation and gene therapy.

Abstract: Provided are a genome editing system CRISPR-C2c1 for site-specific modification of target sequences in a cell genome and the use thereof, wherein the system comprises a C2c1 protein or variants thereof and a guide RNA. Also provided are a method for site-specific modification of target sequences in a cell genome using the genome editing system CRISPR-C2c1, and a pharmaceutical composition comprising the genome editing system CRISPR-C2c1.

Abstract: This application relates to the field of image processing, and in particular, to a multi-lens video recording method and related devices. The method includes: performing collaborative photographing through a plurality of cameras, determining a target camera movement mode based on main subject information in images obtained through photographing and motion information of the cameras, and then fusing, based on the target camera movement mode, the images obtained through photographing by using the plurality of cameras, to implement online camera movement fusion on the plurality of video stream images.

Abstract: The invention relates to the field of genetic engineering. In particular, the present invention relates to a novel eukaryotic genome editing system and method. More specifically, the present invention relates to a CRISPR-Cpf1 system capable of efficiently editing a genome of a eukaryotic cell and the use thereof.

Abstract: A method for displaying commercial advertisements in a virtual reality is disclosed. A user enters the virtual reality visually and audibly through a virtual reality device, the virtual reality device displays a virtual reality application desktop for the user at the same time, and when the user selects the virtual reality application or game, the virtual reality application or game is loaded, in the loading wait process, the user enters the virtual game from the real world through virtual pictures close to reality, which can reduce the abrupt feeling from the real world to the virtual world and avoid the perceived impact caused by the user directly entering the game environment, and the VR application can still continue to load their resources asynchronously. During the long-term VR game, by displaying a close to reality or semi-independent or independent scene, the vision and audition of the user can be relaxed.

Abstract: Provided are an anti-CD40 antibody, an antigen binding fragment thereof, and a medical use thereof. Also provided are a chimeric antibody and a humanized antibody including a CDR region of the anti-CD40 antibody, a pharmaceutical composition including the human anti-CD40 antibody and the antigen binding fragment thereof, and an application thereof as an anti-cancer drug. In particular, provided are a humanized anti-CD40 antibody, and an application thereof in preparation of a drug to treat a CD40-mediated disease or disorder.

Abstract: An anti-corrosive concrete grouting material for coastal structure connection and a method for preparing the same, belonging to the technical field of anti-corrosion of coastal assembled structure connectors. The grouting material includes the following components: expansible compound cement, slag sand, fly ash (FA), polyvinyl alcohol (PVA) (containing an oxidant and a catalyst), graphene oxide (GO), a water reducer, an adjusting admixture, a defoaming agent, a mineral admixture and water.

Abstract: A moulding material contains to an extent of at least 50 wt % of the combination of the following constituents: a) 80 to 95 parts by mass of a polyamide component comprising a1) 70 to 100 parts by wt of PA PACMX and a2) 30 to 0 parts by wt of a linear aliphatic polyamide, b) 4 to 19 parts by mass of a core-shell impact modifier, and c) 1 to 5 parts by mass of a functionalized styrene-ethylene/butylene-styrene block copolymer as an impact modifier, wherein the parts by mass of a), b) and c) sum to 100. The moulding material has a high transparency and a very good notched impact strength.

Abstract: Provided are anti-CLDN18.2 antibodies or antigen-binding fragments thereof, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof.

Abstract: A GOA circuit and a display panel are provided. Each stage of GOA units is equivalent to multiple cascaded GOA units in the conventional GOA circuit and could orderly output multiple scan signals according to their timing such that each stage of GOA units could control multiple rows of the pixel units of the display panel to display an image. In this way, the number of the TFTs in the GOA circuit could be reduced, the layout and space of the GOA circuit could also be reduced such that the size of the side frame could be reduced and the narrow side frame demands could be met.

Abstract: A display panel and a display device are provided. The display panel includes a main display region, a first bendable region, a second bendable region, and a first hollow region. The first bendable region and the main display region are connected to each other and arranged along a first direction. The first bendable region is capable of being bent away from a light-exiting surface of the display panel through a first bending axis. The second bendable region and the main display region are connected to each other and arranged along a second direction. The second direction intersects the first direction. The second bendable region is capable of being bent away from the light-exiting surface of the display panel through a second bending axis. An intersection point of extension lines of the first bending axis and the second bending axis is located in the first hollow region.

Abstract: A polyamide composition contains a) 88.5-98 wt. % of at least one aliphatic polyamide, wherein at least one monomer unit has 10 to 14 carbon atoms, and wherein the aliphatic polyamide is semi-crystalline; and b) 2-11.5 wt. % of an S glass fiber. The weight percentages of a) and b) are based on a total weight of the polyamide composition. The polyamide composition contains neither a polyolefinic impact modifier nor a core-shell modifier. A moulding material containing the polyamide composition is useful, and a moulded article can be produced from the moulding material. A shoe outsole containing the polyamide composition is also useful.

Abstract: The present invention relates to an anti-CD40 antibody, an antigen binding fragment and a pharmaceutical use thereof. Heavy-chain constant regions of the anti-CD40 antibody and the antigen binding fragment thereof contain mutations. Due to the mutations, the anti-CD40 antibody loses the binding activity to Fc?RIII, and the binding of the anti-CD40 antibody and Fc?RIIB is enhanced, thereby losing the antibody-dependent cytotoxicity (ADCC) but improving Fc?RIIB-mediated antibody crosslinking. The mutations in the heavy-chain constant regions enhance the activation of CD40, and enhance the presentation of dendritic cells to antigens. The anti-CD40 antibody and the antigen binding fragment thereof can be used as anti-cancer drugs to treat CD40-mediated diseases or symptoms.

Abstract: A method for detecting the presence and/or amount of a target nucleic acid molecule in a biological sample and a related kit. The method comprises: (a) contacting the biological sample with: i) Cas12b protein, ii) a gRNA targeting a target sequence of the target nucleic acid molecule, and iii) a single-stranded DNA reporter molecule generating a detectable signal after being cleaved to form a reaction mixture; and (b) detecting the presence and/or level of the detectable signal generated in the reaction mixture.

Abstract: A polymer based composite contains (a) a polyamide component, (b) a (co)-polyamide based on ether units and amide units, and (c) carbon black. It has been found that (1) the (co)-polyamide (b) offers sufficient absorbency for the printing ink, and (2) the selection of the polyamide component, the (co)-polyamide, and the amount of the carbon black result in both sufficient transparency and sufficient absorption centers for the laser energy. A moulded article can be made of the polymer based composite. A layered structure can be made containing at least one layer made of the polymer based composite and a security and/or valuable document containing the layered structure.

Abstract: The present disclosure relates to a human IL-4R binding antibody, an antigen binding fragment thereof, and a medical use thereof. Provided are a chimeric antibody and a humanized antibody, including a CDR region from a human IL-4R binding antibody and an antigen binding fragment thereof, a pharmaceutical composition including the human IL-4R binding antibody and the antigen binding fragment thereof, and a use thereof as a drug treating allergic disease. Also provided is a use of the humanized antibody IL-4R binding antibody in preparing a drug used for treating IL-4R mediated diseases or illnesses.

Abstract: A laser markable polymer composite contains (a) a polyamide component as the matrix and (b) carbon black as a laser-sensitive additive. The polyamide component has, based on the total weight thereof, at least 50 wt % a poly amide selected from a linear aliphatic polyamide (a1) or (a2), a cycloaliphatic polyamide (a3), a semi-aromatic polyamide (a4) or (a5), and the compound or copolymer thereof. The carbon black is present in an amount of 50-300 ppm, based on the total weight of the polymer composite. The composite results in better chemical resistance than conventional polycarbonate as the matrix, in addition to a desired quality of laser marking, specifically sharpness and resolution. This composite can also be used for a moulded article made of the laser markable polymer composite, a layered structure with at least one layer made of the laser markable polymer composite, and a security and/or valuable document with the layered structure.