Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: This invention claims a use of Capsicum and Oleoresin capsicum (OC) as a chemical shark repellent. Alkyl chain , antioxidant phenolic group, and pungency properties of capsaicin contained in OC can exert a hostile reaction on lipit membrane of gills and on nonmedullated fibre nerves of body surface of sharks, herein is provided different ways to deter sharks maintaining a high concentration of OC or Capsicum close and safe to the swimmer and scuba diver, permitting it a maximum deterrent force against sharks, It is also suitable as a coating by using paint for rescue operations devices such as the Johnson shark screen and the infant flotation device. Also this invention is proposed a use of a device for delivering a rapid squirt or atomized blast of OC to repel sharks.