Abstract: A multi-layer film for seal-peel applications, an article comprising said film and the use of said film a disclosed. The multi-layer film for seal-peel application comprising at least two layers, namely a cover layer and a seal layer, whereby the seal layer comprises between 25 and 80 wt. % of EVA and between 20 and 75 wt. % of LLDPE based on the total weight of the layer.

Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

Abstract: A reconfigurable optical add and drop multiplexer (ROADM) system is provided. The ROADM system may include a switching system which includes at least one first WSS optically coupled to a tapping coupler and configured to receive an input optical signal from a first circulator, transmit a drop optical signal to a demultiplexer to drop one or more first wavelength channels, and output a through optical signal. The switching system may also include at least one second WSS optically coupled to the at least one first WSS and a multiplexer and configured to receive an add optical signal to add one or more second wavelength channels, receive the through optical signal, and output an output optical signal to a second circulator, and at least one OCM configured to monitor the input optical signal and the output optical signal.

Abstract: At least one computer processor can replace visual words of an unsupervised machine learning classification model with visual objects of an image. At least two co-occurring single visual objects adjacent to each other in pixels of the image can be combined to obtain a compound visual object. The unsupervised machine learning classification model can be augmented to model the image as a mixture of subjects, where each subject is represented through placements of the visual objects in a mixture of concentric spheres centering on a mixture of intersections on a mixture of horizontal layers. At least one processor can learn latent relationships between the placements of the visual objects in a three-dimensional space depicted in the image and image semantics. Learning the latent relationships trains the unsupervised machine learning classification model to perform image subject classification through the placements of the visual objects in a new image.

Abstract: A system and method for CO2 capture and electroregeneration and synchronous conversion are provided. The system includes a CO2 capture subsystem, which uses an absorption liquid to capture CO2 and generate a capture liquid; and a CO2 electroregeneration and synchronous conversion subsystem, including a cathode chamber provided with a cathode electrode, a sample inlet, and a sample outlet, an anode chamber having an anode electrode, a sample inlet connected to an outlet of the capture liquid of the CO2 capture subsystem, and a sample outlet connected to the sample inlet of the cathode chamber for introducing CO2 regenerated by anodic oxidation into the cathode chamber for electroreduction, and a balance chamber in the middle having a sample outlet connected to an inlet of the absorption liquid of the CO2 capture subsystem. The system can perform self-circulation and stably operate, to capture, regenerate and convert CO2.

Abstract: The present disclosure relates to a thermal coupling method for preparing ethylene by ethanol dehydration and device thereof. The device includes an ethanol dehydration reaction system, a quenching compression system, an alkaline washing system, a molecular sieve drying system and an ethylene purification and propylene refrigeration cycle system; ethanol dehydration reaction products in the ethanol dehydration reaction system serve as a heat source for preheating, vaporization and superheating of a raw material of ethanol; tower bottoms of an evaporation tower in the quenching compression system serve as a heat source for preheating of a feed stream of the evaporation tower and heating of an overhead gas of a quenching tower; products of ethylene in the alkaline washing system serve as a cold source for cooling of crude ethylene.

Abstract: Disclosed are a coating for glass molding, a preparation method and application thereof and a mold having the coating. The coating includes a nitride layer and nano precious metal particles which are dispersed in the nitride layer. A surface roughness of the coating is 2-12 nm. The preparation method of the coating includes: cleaning a substrate and targets under an inert gas; and under a mixed atmosphere of nitrogen and the inert gas, depositing, with a high-purity W target, a high-purity Cr target and a precious metal inserted Cr target, a Cr intermediate layer, a nitride layer and nano precious metal particles on a surface of the substrate. The coating has good oxidation resistance and excellent anti-adhesion property. Moreover, the coating effectively inhibits the adhesion between the glass body and the mold.

Abstract: A micro- and nano-hot embossing method for an optical glass lens array, including: preparing a mold with a micro-hole array by micro EDM, where the micro-hole array matches an optical glass lens array and the mold is made of a hard metal material which is conductive and meets strength and temperature requirements; preparing a nano nitride-based graded composite coating on a surface of the mold by magnetron sputtering; and pre-fabricating a glass preform and then placing the glass preform on the surface of the mold; heating the glass preform and hot embossing by a glass molding machine in vacuum; cooling in nitrogen atmosphere; and demolding to produce the optical glass lens array. The micro- and nano-hot embossing method of the present invention improves the surface quality of the optical glass lens array and reduces the cost and difficulty for manufacturing.

Abstract: Disclosed is a coating made of an organic material on a mold for glass molding. The coating comprises CrxWyN(1-x-y), where 0.15<x<0.4, and 0.2?y?0.45. The coating has excellent high temperature resistance and anti-adhesion properties, thus being a promising coating material for molds.

Abstract: Disclosed are coatings made of inorganic materials on molds for glass molding, particularly, a graded coating of element diffusion inhibition and adhesion resistance on molds for glass molding. The graded coating includes a Cr adhesion layer which is bonded with a substrate, a CrN intermediate layer and a CrxWyN(1-x-y) surface layer, where 0.15<x<0.4, and 0.2?y<0.45. The graded coating has excellent crack growth suppression and adhesion resistance.

Abstract: The present application falls within the field of medicinal chemistry, relates to the crystalline of a compound as a c-Met kinase inhibitor, and specifically relates to the crystalline of N-(4-((7-((1-(cyclopentylamino)cyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and a preparation method therefor, a crystalline composition thereof, and a pharmaceutical composition thereof, as well as the use of the crystalline for treating diseases associated with the inhibition of growth factor receptor protein tyrosine kinase activity. The crystalline of the present application has excellent properties in at least one of the following aspects: pharmacokinetics, bioavailability, hygroscopicity, stability, solubility, purity, ease of preparation, etc.

Abstract: A system and a method for fabrication of bulk nanocrystal alloys is provided. The method may include subjecting powders of at least one material to an ultrasonic vibration at a first amplitude. The method may also include heating the powders in response to the ultrasonic vibration at a first temperature elevating rate corresponding to the first amplitude, and treating the powders in a temperature range corresponding to the first temperature elevating rate. The method may further include obtaining a bulk material composed of a plurality of crystal grains, the plurality of crystal grains having an average linear dimension equal to or larger than 10 nm. The method may further include obtaining a bulk material with amorphous structure with sufficient temperature cooling rate.

Abstract: Among the various aspects of the present disclosure is the provision of miRNA mimics and uses thereof. An aspect of the present disclosure provides for compositions of miRNA mimic molecules and methods of treating metabolic disorders using miRNA mimic molecules.

Abstract: Disclosed are a coating for glass molding, a preparation method and application thereof and a mold having the coating. The coating includes a nitride layer and nano precious metal particles which are dispersed in the nitride layer. A surface roughness of the coating is 2-12 nm. The preparation method of the coating includes: cleaning a substrate and targets under an inert gas; and under a mixed atmosphere of nitrogen and the inert gas, depositing, with a high-purity W target, a high-purity Cr target and a precious metal inserted Cr target, a Cr intermediate layer, a nitride layer and nano precious metal particles on a surface of the substrate. The coating has good oxidation resistance and excellent anti-adhesion property. Moreover, the coating effectively inhibits the adhesion between the glass body and the mold.

Abstract: The present application falls within the field of medicinal chemistry, relates to the crystalline of a compound as a c-Met kinase inhibitor, and specifically relates to the crystalline of N-(4-((7-((1-(cyclopentylamino)cyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and a preparation method therefor, a crystalline composition thereof, and a pharmaceutical composition thereof, as well as the use of the crystalline for treating diseases associated with the inhibition of growth factor receptor protein tyrosine kinase activity. The crystalline of the present application has excellent properties in at least one of the following aspects: pharmacokinetics, bioavailability, hygroscopicity, stability, solubility, purity, ease of preparation, etc.

Abstract: Disclosed is a coating made of an organic material on a mold for glass molding. The coating comprises CrxWyN(1-x-y), where 0.15<x<0.4, and 0.2?y?0.45. The coating has excellent high temperature resistance and anti-adhesion properties, thus being a promising coating material for molds.

Abstract: A micro- and nano-hot embossing method for an optical glass lens array, including: preparing a mold with a micro-hole array by micro EDM, where the micro-hole array matches an optical glass lens array and the mold is made of a hard metal material which is conductive and meets strength and temperature requirements; preparing a nano nitride-based graded composite coating on a surface of the mold by magnetron sputtering; and pre-fabricating a glass preform and then placing the glass preform on the surface of the mold; heating the glass preform and hot embossing by a glass molding machine in vacuum; cooling in nitrogen atmosphere; and demolding to produce the optical glass lens array. The micro- and nano-hot embossing method of the present invention improves the surface quality of the optical glass lens array and reduces the cost and difficulty for manufacturing.

Abstract: Disclosed are coatings made of inorganic materials on molds for glass molding, particularly, a graded coating of element diffusion inhibition and adhesion resistance on molds for glass molding. The graded coating includes a Cr adhesion layer which is bonded with a substrate, a CrN intermediate layer and a CrxWyN(1-x-y) surface layer, where 0.15<x<0.4, and 0.2?y<0.45. The graded coating has excellent crack growth suppression and adhesion resistance.

Abstract: A multi-layer film for seal-peel applications, an article comprising said film and the use of said film a disclosed. The multi-layer film for seal-peel application comprising at least two layers, namely a cover layer and a seal layer, whereby the seal layer comprises between 25 and 80 wt. % of EVA and between 20 and 75 wt. % of LLDPE based on the total weight of the layer.

Abstract: It relates to a multi-layer film for seal-peel applications, an article comprising said film and the use of said film.