Abstract: The present invention provides methods for targeting interleukin-2 receptor-expressing cells, and, in particular, inhibiting the growth of such cells by using an interleukin-2 (IL-2) variant conjugated to a biologically active molecule that will affect cells expressing the interleukin-2 receptor.

Abstract: A kitchen appliance is disclosed for cooking a meat product. The kitchen appliance includes a heating element adapted to heat a medium for transferring heat to the meat product, a sensor for detecting loss of water from a contact surface of the meat product with the medium, and a controller conductively coupled to the sensor. The controller processes a sensor signal produced by the sensor, and generates a control signal indicative of the meat product reaching a defined cooking state in response to the processed sensor signal being indicative of a loss of water associated with the desired cooking state from the contact surface of the meat product.

Abstract: A luminaire mounting kit (10) is disclosed comprising a luminaire (100) having a mounting section (110) comprising a recessed section (120) carrying a first gear wheel portion (121), the recessed section being flanked by at least one protruding section (130) carrying a second gear wheel portion (131); and a mounting body (200) for engaging with the mounting section, the mounting body comprising a protruding end portion (220) carrying a first further gear wheel portion (221) for engaging with the first gear wheel portion; and at least one recessed side portion (230) flanking said end portion and carrying a second further gear wheel portion (231) arranged to simultaneously engage with the second gear wheel portion when the first further gear wheel portion engages with the first gear wheel portion. Also disclosed is a luminaire assembly and a method of mounting such a luminaire kit onto a mounting surface.

Abstract: This invention relates to prostate-specific membrane antigen (PSMA) antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are ?PSMA antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the ?PSMA antibodies of the invention are conjugated to one or more toxins. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, dolastatin analogs, and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.

Abstract: The present disclosure relates to the field of stroke-controlling mechanism, and discloses a stroke-limiting control assembly and an operating method. The stroke-limiting control assembly comprises a housing and a film winding. A transmission input gear, a transmission gear, a guide wheel, and a spring box that can be rotated to reset by an elastic force are rotatably connected within the housing. When a moving component moves to an end of an upper stroke, a first metal needle abuts a first proximity switch. When the movable component moves to an end of a lower stroke, a second metal needle abuts against a second proximity switch. At least a stroke-limiting control assembly is provided which enables simplification of a product requiring stroke-limiting, such as an electric jack or an electric support leg, by arranging the proximity switches outside a screw nut lifting unit in the electric jack or the electric support leg.

Abstract: The present invention provides methods for targeting interleukin-10 receptor-expressing cells, and, in particular, inhibiting the growth of such cells by using an interleukin-10 (IL-10) variant conjugated to a biologically active molecule that will affect cells expressing the interleukin-10 receptor.

Abstract: The present disclosure is directed to an optical device including at least one temperature-dependent tunable element for controlling a wavelength of an optical signal, a first temperature control circuit for controlling a temperature of a first region of the optical device; and a second temperature control circuit for controlling a temperature of a second region of the optical device. The second region may include a portion of the first region. The second region may be smaller than the first region. The tunable element may be positioned in the second region such that a temperature of the tunable element is controlled based on the second temperature control circuit controlling the temperature of the second region. The tunable element may be one of (i) a laser for transmitting an outgoing optical signal and (ii) an optical filter coupled to a photodetector for receiving an incoming optical signal.

Abstract: The invention discloses a genetically engineered bacterium in which the gene encoding adenine deaminase on the genome of the bacterium is knocked out or/and the gene encoding the enzyme in the NAD+ anabolic pathway is integrated on the genome of the bacterium. The invention also discloses a construction method of the above-mentioned genetically engineered bacteria. The gene encoding adenine deaminase on the genome of the host strain is knocked out to obtain a strain with high NAD+ yield. Or the expression cassettes of the gene encoding the enzyme in the NAD+ synthesis pathway are constructed separately, and then the enzyme encoding The gene expression cassette is integrated into the genome of the host strain whose gene encoding adenine deaminase is knocked out to construct a strain with high NAD+ production. The application of the above genetically engineered bacteria is disclosed. A method of producing NAD+ is disclosed.

Abstract: Techniques relating to monitoring map consistency are described. In an example, a monitoring component associated with a vehicle can receive sensor data associated with an environment in which the vehicle is positioned. The monitoring component can generate, based at least in part on the sensor data, an estimated map of the environment, wherein the estimated map is encoded with policy information for driving within the environment. The monitoring component can then compare first information associated with a stored map of the environment with second information associated with the estimated map to determine whether the estimated map and the stored map are consistent. Component(s) associated with the vehicle can then control the object based at least in part on results of the comparing.

Abstract: Described herein are novel anti-CD3 Folate antibodies and uses thereof in the treatment of diseases or conditions that would benefit from such.

Abstract: An apparatus is arranged to heat smokable material (5) to volatilize at least one component of the smokable material. In one exemplary embodiment, the apparatus has a housing and a plurality of heater segments longitudinally arranged within the housing for heating smokable material contained within the apparatus. At least one heater segment is arranged so as to heat smokable material contained within the at least one heater segment more quickly than at least one other heater segment heats smokable material contained within the at least one other heater segment.

Abstract: The present invention relates to an alkyl chitosan-graphene oxide composite sponge and preparation method and application thereof. The alkyl chitosan-graphene oxide composite sponge provided by the present invention includes alkyl chitosan and graphene oxide absorbed on the alkyl chitosan, and the adsorbing capacity of the graphene oxide is 3-28 wt. %. In the present invention, alkyl chitosan is used as a matrix to combine graphene oxide and alkyl chitosan; the obtained composite sponge has excellent hemostatic performance and blood absorption capacity. Results of embodiments indicate that the in-vitro whole blood coagulation time is less than 58 s, the hemostasis time of a rabbit femoral artery hemorrhage model is less than 155 s, the hemorrhage mass is less than 5.4 g, and the hemostatic effect is superior to a pure alkyl chitosan sponge or graphene oxide powder when the composite sponge provided by the present invention is used for hemostasis.

Abstract: An apparatus is arranged to heat smokable material (5) to volatilize at least one component of the smokable material. In one exemplary embodiment, the apparatus has a housing and a plurality of heater segments longitudinally arranged within the housing for heating smokable material contained within the apparatus. At least one heater segment is arranged so as to heat smokable material contained within the at least one heater segment more quickly than at least one other heater segment heats smokable material contained within the at least one other heater segment.

Abstract: A controller for use in a power converter for transferring energy between an input and an output, the controller comprising a second controller to generate a request event and a request signal in response to a feedback signal and a switching window signal, the second controller to transmit the request event during a switching window of the switching window signal. The second controller comprising an extremum locator switching window generator to generate the switching window corresponding with an extremum in the winding signal and a measurement enable circuit to output an enable signal to enable the extremum locator switching window generator to measure a duration of a half cycle to generate the switching window. The measurement enable circuit to enable the extremum locator switching window generator in response to the feedback signal reaching a percentage of a target reference and output a quiet signal to prevent transmitting the request event.

Abstract: A method, terminal and device for establishing security infrastructure, comprising: an intermediate service organization receives an organization secret key sent by a third-party service organization; the intermediate service organization encrypts the organization secret key by a first encryption means and sends the encrypted organization secret key to a security storage region of a terminal; the intermediate service organization receives a first terminal public key encrypted by the terminal using a second encryption means; and the intermediate service organization sends the first terminal public key obtained by decryption to the third-party service organization.

Abstract: Disclosed herein are methods, compositions and components for optimizing or increasing expression of a protein, polypeptide or fragment therefrom.

Abstract: Scene filtering using motion estimation, including identifying, in camera data from an autonomous vehicle, based on motion relative to the autonomous vehicle, one or more pixels; filtering, from the camera data, the one or more pixels; and training, based on the filtered camera data, a neural network.

Abstract: Camera data normalization for an autonomous vehicle are described herein, including: receiving, from one or more cameras of the autonomous vehicle, camera data; applying a color normalization to the camera data; applying a spherical reprojection to the camera data; and applying, based on a registration point, a stabilization to the camera data.

Abstract: Motion-based scene selection for an autonomous vehicle may include identifying, in camera data from an autonomous vehicle, based on a plurality of motion vectors associated with the camera data, one or more image objects; determining, for each image object of the one or more image objects, based on the one or more motion vectors, a corresponding label of one or more labels; and encoding the one or more labels in association with the camera data.

Abstract: Determining control operations for an autonomous vehicle may include receiving, by an operational model, an operational model input based on camera data from one or more cameras of an automated vehicle; determining, by the operational model, based on the input, a current environmental state and a predicted environmental state; providing, to a rules module, a differential between the current environmental state and a previously predicted environmental state; and determining, based on the rules module, one or more control operations for the automated vehicle.