Abstract: A shoe platen to securely hold a shoe so that graphics, including custom graphics, can be printed on the shoe automatically. The platen comprises a shoe plate 102 configured to receive shoes such as high-top shoes or low top shoes. Adjusters 104, 106 can also be used to accommodate shoes of various styles and sizes.

Abstract: A shoe platen to securely hold a shoe so that graphics, including custom graphics, can be printed on the shoe automatically. The platen comprises a shoe plate 102 configured to receive shoes such as high-top shoes or low top shoes. Adjusters 104, 106 can also be used to accommodate shoes of various styles and sizes.

Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: A cap platen to securely hold headwear, such as caps, hats, and the like, so that graphics, including custom graphics, can be printed on the cap automatically. The platen has a vise plate to support the bill of a cap and a face plate attached to the vise plate to hold the crown of cap. Arms can be attached to the vise plate or the face plate to apply a biasing force against the sides of the cap pushed the sides of the cap outwardly away from the face plate.

Abstract: In one embodiment, the system obtains first information pertaining to one or more physical entities with respect to a user. The system creates or updates a profile pertaining to the user based, at least in part, upon the first information. The system provides second information to the user based, at least in part, upon the profile that has been created or updated.

Abstract: In one embodiment, an event that has recently occurred is identified. The event is categorized into a category of events from a plurality of categories. A set of one or more advertisements associated with the category of events is ascertained. At least one advertisement is selected from the set of one or more advertisements associated with the category of events. The at least one advertisement is then provided to a user.

Abstract: In one embodiment, a group of two or more individuals may be identified. A set of one or more features of the group of two or more individuals may be ascertained. An item may be selected from a plurality of items based, at least in part, upon the set of one or more features of the group of two or more individuals. The item may be recommended or presented to at least a portion of the two or more individuals.

Abstract: In one embodiment at least one user profile of a user may be obtained. Information may be provided to the user by one or more personalization engines based, at least in part, upon the at least one user profile. Each of the one or more personalization engines may be configured to operate according to a different one of a plurality of personas.

Abstract: In one embodiment, a set of advertisements may be identified based, at least in part, upon a profile of a user. The set of advertisements may include a plurality of advertisements, where each of the plurality of advertisements corresponds to a different one of a plurality of contexts. A context of the user may be ascertained. One of the plurality of advertisements may be selected based, at least in part, upon the context of the user. The selected one of the plurality of advertisements may be provided.

Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: A cap platen to securely hold headwear, such as caps, hats, and the like, so that graphics, including custom graphics, can be printed on the cap automatically. The platen has a vise plate to support the bill of a cap and a face plate attached to the vise plate to hold the crown of cap. Arms can be attached to the vise plate or the face plate to apply a biasing force against the sides of the cap pushed the sides of the cap outwardly away from the face plate.

Abstract: A shoe platen to securely hold a shoe so that graphics, including custom graphics, can be printed on the shoe automatically. The platen comprises a shoe plate 102 configured to receive shoes such as high-top shoes or low top shoes. Adjusters 104, 106 can also be used to accommodate shoes of various styles and sizes.

Abstract: The present invention relates to the use of novel triazolopyridine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: Compounds represented by Formula I: which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of making said compounds, wherein Ar, Z, R, R?, R5 and R10 are as defined herein.

Abstract: Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) wherein R1-R3 R6c and X1 are as defined herein are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula I.

Abstract: Compounds represented by Formula I: which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of making said compounds, wherein Ar, Z, R, R?, R5 and R10 are as defined herein.

Abstract: This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Z is —C(O)— or —S(O)2—, X is carbon or nitrogen, Y is carbon, and X-Y considered together are two adjoining atoms of the ring A, said ring being a fused aromatic ring of five to six atoms per ring optionally incorporating one to two heteroatoms per ring, chosen from N, O, or S; and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

Abstract: Compounds which are alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Q is a monocyclic or bicyclic optionally-substituted heterocyclic ring as defined herein; Z is —C(?O)— or —S(?O)2—; R and R? are lower alkyl; R5 is halogen, cyano, hydroxy, —R6, or —OR6; and R6 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclo, or substituted heterocyclo; and pharmaceutically-acceptable salts, hydrates, prodrugs, and isomers thereof.

Abstract: This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Z is —C(O)— or —S(O)2—, X is carbon or nitrogen, Y is carbon, and X—Y considered together are two adjoining atoms of the ring A, said ring being a fused aromatic ring of five to six atoms per ring optionally incorporating one to two heteroatoms per ring, chosen from N, O, or S; and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.