Patents by Inventor Fernando Pelaez
Fernando Pelaez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100279861Abstract: Novel isoxazolidinone compounds useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops are described. Two novel strains of fungi, ATCC No. PAT-7894 and ATCC No. PAT-7895, are disclosed for the preparation of the described isoxazolidinone compounds.Type: ApplicationFiled: August 12, 2008Publication date: November 4, 2010Inventors: Gerald F Bills, Javier Collado, Craig A. Parish, Fernando Pelaez, Gonzalo Platas, Terry Roemer
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Patent number: 6403347Abstract: Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.Type: GrantFiled: October 25, 1999Date of Patent: June 11, 2002Assignee: Merck & Co., Inc.Inventors: Gerald F. Bills, Russell B. Lingham, Ali Shafiee, Keith C. Silverman, Sheo Bux Singh, Deborah L. Zink, Fernando Pelaez, Ana M. Teran
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Patent number: 6245806Abstract: Novel tetracyclic aromatic ketones are natural product compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. Further, the novel fungal cultures MF6388 (ATCC 74478), Sterile Fungus, and MF6591 (ATCC 74477), Ascochyta sp. are also disclosed. Further, the cultures Sterile Fungus MF6388 (ATCC 74478) and Ascochyta sp. MF6591 (ATCC 74477) are also disclosed, as well as processes for making compounds of the present invention employing the cultures.Type: GrantFiled: July 25, 2000Date of Patent: June 12, 2001Assignee: Merck & Co., Inc.Inventors: Anne Dombrowski, Sheo Singh, Deborah L. Zink, Ana Teran, Fernando Pelaez, Daria Hazuda
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Patent number: 6051597Abstract: Indolylquinones are useful for the treatment and prevention of diabetes mellitus, and in particular, for the treatment or prevention of hyperglycemia in diabetic patients. Some of the indolylquinones are produced by fermentation of the novel fungus Pseudomassaria sp. ATCC 74411.Type: GrantFiled: June 10, 1998Date of Patent: April 18, 2000Assignee: Merck & Co., Inc.Inventors: Bei Zhang, Royo Inmaculada, Fernando Pelaez, Gino M. Salituro, Gerald F. Bills
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Patent number: 5994412Abstract: A compound represented by the formula I is disclosed: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof. The compound has inhibitory activity against the oncoprotein Raf.Also included are pharmaceutical compositions, methods of treating cancer, cultures of the producing fungal microorganism and methods of fermentative production of the compound.Type: GrantFiled: July 2, 1998Date of Patent: November 30, 1999Assignee: Merck & Co., Inc.Inventors: Seok H. Lee, Maria T. Diez, Fernando Pelaez, Marina Mojena Sanchez, M. Dolores Vilella Amils, Hans E. Huber, Denis R. Patrick, Otto D. Hensens, Rosalind G. Jenkins, Leeyuan Huang, Annie Z. Zhao, Deborah L. Zink, Anne Dombrowski, Gerald F. Bills
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Patent number: 5801172Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.Type: GrantFiled: July 11, 1997Date of Patent: September 1, 1998Assignee: Merck & Co., Inc.Inventors: Wendy H. Clapp-Shapiro, Bruce W. Burgess, Robert A. Giacobbe, Guy H. Harris, Suzanne Mandala, Jon Polishook, Mark Rattray, Rosemary A. Thornton, Deborah L. Zink, Angeles Cabello, Maria Teresa Diez, Isabel Martin, Fernando Pelaez
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Patent number: 5789438Abstract: The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.Type: GrantFiled: September 5, 1997Date of Patent: August 4, 1998Assignee: Merck & Co., Inc.Inventors: Sheo B. Singh, Russell B. Lingham, Keith C. Silverman, Deborah L. Zink, Isabel Martin, Fernando Pelaez, Manuel Sanchez
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Patent number: 5770587Abstract: There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.Type: GrantFiled: October 21, 1996Date of Patent: June 23, 1998Assignee: Merck & Co., Inc.Inventors: Angela Basilio, Fernando Pelaez, Maria Teresa Diez, Francisca Vicente, Sandra A. Morris, James E. Curotto, Gerald F. Bills, Sarah J. Dreikorn, Otto D. Hensens, Jerrold M. Liesch, Rosalind G. Jenkins, John R. Thompson
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Patent number: 5756472Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.Type: GrantFiled: January 27, 1997Date of Patent: May 26, 1998Assignee: Merck & Co., Inc.Inventors: Jerrold M. Liesch, Maria S. Meinz, Janet C. Onishi, Sandra A. Morris, Robert E. Schwartz, Gerald F. Bills, Robert A. Giacobbe, Wendy S. Horn, Deborah L. Zink, Angeles Cabello, Maria T. Diez, Isabella Martin, Fernando Pelaez, Francisca Vicente
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Patent number: 5712109Abstract: There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.Type: GrantFiled: January 27, 1997Date of Patent: January 27, 1998Assignee: Merck & Co., Inc.Inventors: Jerrold M. Liesch, Maria S. Meinz, Janet C. Onishi, Robert E. Schwartz, Gerald F. Bills, Robert A. Giacobbe, Deborah L. Zink, Angeles Cabello, Maria T. Diez, Isabella Martin, Fernando Pelaez, Francisca Vicente
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Patent number: 5712151Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.Type: GrantFiled: October 21, 1996Date of Patent: January 27, 1998Assignee: Merck & Co., Inc.Inventors: Sandra A. Morris, Gerald F. Bills, James E. Curotto, Sarah J. Dreikorn, Angela Basilio, Maria Teresa Diez, Fernando Pelaez, Francisca Vicente, Bruce W. Burgess, Stanley L. Streicher, Deborah L. Zink, John R. Thompson
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Patent number: 5702929Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.Type: GrantFiled: October 21, 1996Date of Patent: December 30, 1997Assignee: Merck & Co., Inc.Inventors: Sandra A. Morris, James E. Curotto, Gerald F. Bills, Sarah J. Dreikorn, Stanley L. Streicher, Deborah L. Zink, John R. Thompson, Angela Basilio, Fernando Pelaez, Maria Teresa Diez, Francisca Vicente
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Patent number: 5703067Abstract: The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.Type: GrantFiled: May 8, 1995Date of Patent: December 30, 1997Assignee: Merck & Co., Inc.Inventors: Hiranthi Jayasuriya, Russell B. Lingham, Fernando Pelaez, Manuel Sanchez, Keith C. Silverman, Sheo Bux Singh, Deborah L. Zink
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Patent number: 5686637Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.Type: GrantFiled: January 10, 1995Date of Patent: November 11, 1997Assignee: Merck & Co., Inc.Inventors: Gerald F. Bills, James E. Curotto, S. Dreikorn, Robert A. Giacobbe, Guy H. Harris, Suzanne Miller Mandala, Rosemary A. Thornton, Deborah L. Zink, Angeles Cabello Arroyo, Fernando Pelaez Perez, Teresa Diez Matas, Francisca Vicente Perez
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Patent number: 5663193Abstract: The present invention is directed to non-peptide compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention also relates to the process for the preparation of a compound of this invention by cultivating a culture of Phoma sp. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.Type: GrantFiled: July 17, 1996Date of Patent: September 2, 1997Assignee: Merck & Co., Inc.Inventors: Carmen Cascales, Russell B. Lingham, Fernando Pelaez, Jon D. Polishook, Keith C. Silverman, Sheo B. Singh, Deborah L. Zink
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Patent number: 5543429Abstract: There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.Type: GrantFiled: March 9, 1995Date of Patent: August 6, 1996Assignee: Merck & Co., Inc.Inventors: Gerald F. Bills, James E. Curotto, Sarah J. Dreikorn, Rosalind G. Jenkins, Jerrold M. Liesch, Sandra A. Morris, John R. Thompson, Deborah L. Zink, Richard K. Jansson, Angela Basilio, Teresa Diez, Fernando Pelaez, Francisca Vicente
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Patent number: 5543431Abstract: A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.Type: GrantFiled: May 24, 1995Date of Patent: August 6, 1996Assignee: Merck & Co., Inc.Inventors: Evon A. Bolessa, Robert E. Schwartz, Gerald F. Bills, Robert A. Giacobbe, Fernando Pelaez Perez, Angeles Cabello Arroyo, Teresa Diez Matas, Isabel Martin Fernandez, Francisca Vicente Perez, Suzanne M. Mandala, Deborah L. Zink, Rosemary Thornton, John R. Thompson, James E. Curotto
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Patent number: 5461071Abstract: A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.Type: GrantFiled: October 21, 1994Date of Patent: October 24, 1995Assignee: Merck & Co., Inc.Inventors: Evon A. Bolessa, Robert E. Schwartz, Gerald F. Bills, Robert A. Giacobbe, Fernando Pelaez Perez, Angeles Cabello Arroyo, Teresa Diez Matas, Isabel Martin Fernandez, Francisca Vincente Perez, Suzanne M. Mandala, Deborah L. Zink, Rosemary Thornton, John R. Thompson, James E. Curotto
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Patent number: 5352800Abstract: Fermentation processes for the production of a compound of the Structural Formula I ##STR1## The compound of Structural Formula I has been shown to have endothelin antagonist activity and is therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure vasospasm, cerebral and cardia ischemia, myocardial infarction inflammatory diseases, Raynaud's disease, endotoxin shock and asthma.Type: GrantFiled: March 11, 1993Date of Patent: October 4, 1994Assignee: Merck & Co., Inc.Inventors: Gerard F. Bills, Michael A. Goetz, Robert A. Giacobbe, Lucia Herranz, E. Tracy Turner Jones, Fernando Pelaez, Yu L. Kong, Sheo B. Singh, Siobhan Stevens-Miles
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Patent number: 5348970Abstract: A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.Type: GrantFiled: September 22, 1993Date of Patent: September 20, 1994Assignee: Merck & Co., Inc.Inventors: Robert E. Schwartz, Janet C. Onishi, Gerald F. Bills, Robert A. Giacobbe, Fernando Pelaez, Maria T. Diez, Francisca Vicente, Julian Gorrochategui, Gregory L. Helms, Barnali Pramanik