Abstract: A method of preparing a pharmaceutical formulation which is suitable for inhalation, the method comprising: providing a solution comprising a first solvent or mixture of solvents and a poorly water soluble active agent; providing a second solution comprising a second solvent or mixture of solvents and an excipient. The first and second solvents or mixture of solvents are removed by simultaneously drying both solutions in a spray dryer equipped with a three-fluid nozzle to produce particles comprising an active agent and an excipient.

Abstract: Systems and methods for enhancing node operation in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for adapting mobile access point coverage, for example adapting a mobile access point of a vehicle (e.g., an autonomous vehicle, a manually locally controlled vehicle, a remotely controlled vehicle, etc.).

Abstract: A method for the preparation of respirable zafirlukast monohydrate particles comprises the steps of preparation of an aqueous suspension of amorphous zafirlukast; size-reduction with conversion of the suspended zafirlukast into crystalline monohydrate nanoparticles; and isolation of the crystalline zafirlukast in the form of a dry powder. Also provided are zafirlukast respirable particles characterized by comprising crystalline monohydrate zafirlukast. Pharmaceutical compositions comprising the particles are also disclosed, as is the use of the particles or compositions for the treatment of respiratory diseases.

Abstract: Systems and methods for managing connectivity in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for managing connectivity in a network in which at least a portion of the network access points are moving.

Abstract: Systems and methods for managing mobility in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for managing mobility in a network in which at least a portion of the network access points are moving.

Abstract: Systems and methods for shipping management in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for integrating sensors, mobile access points, and/or the network of moving things with shipping container management systems (e.g., port management systems, train management systems, trucking management systems, etc.).

Abstract: A method for the preparation of respirable zafirlukast monohydrate particles comprises the steps of preparation of an aqueous suspension of amorphous zafirlukast; size-reduction with conversion of the suspended zafirlukast into crystalline monohydrate nanoparticles; and isolation of the crystalline zafirlukast in the form of a dry powder. Also provided are zafirlukast respirable particles characterized by comprising crystalline monohydrate zafirlukast. Pharmaceutical compositions comprising the particles are also disclosed, as is the use of the particles or compositions for the treatment of respiratory diseases.

Abstract: Systems and methods for managing mobility in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for managing mobility in a network in which at least a portion of the network access points are moving.

Abstract: This present invention provides a spray dryer for use in preparing particles for inhalation, the spray dryer comprising a multi-nozzle apparatus comprising multiple single nozzles suitable for use in preparing inhalation powders and with a drying gas flow rate greater than about 80 kg/h. Also provided is a method for scaling-up a spray drying process for preparing particles for inhalation from a smaller scale spray dryer to a larger scale spray dryer, relative in size to each other, the method comprising the use in the larger scale spray dryer of a multi-nozzle apparatus comprising single nozzles suitable for use in preparing inhalation powders, wherein the number of nozzles in the larger spray dryer is determined by the ratio of the drying gas flow rate of the larger scale spray dryer to the drying gas flow rate of the smaller scale spray dryer.

Abstract: Communication network architectures, systems and methods for supporting a network of mobile nodes. As a non-limiting example, various aspects of this disclosure provide communication network architectures, systems, and methods for integrating and/or integrating with a communication network comprising a complex array of both static and moving communication nodes (e.g., the Internet of moving things).

Abstract: Systems and methods for managing connectivity in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for managing connectivity in a network in which at least a portion of the network access points are moving.

Abstract: Systems and methods for managing mobility in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for managing mobility in a network in which at least a portion of the network access points are moving.

Abstract: Systems and methods for managing connectivity in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for managing connectivity in a network in which at least a portion of the network access points are moving.

Abstract: A method of preparing a pharmaceutical formulation which is suitable for inhalation, the method comprising: providing a solution comprising a first solvent or mixture of solvents and a poorly water soluble active agent; providing a second solution comprising a second solvent or mixture of solvents and an excipient. The first and second solvents or mixture of solvents are removed by simultaneously drying both solutions in a spray dryer equipped with a three-fluid nozzle to produce particles comprising an active agent and an excipient.

Abstract: The present invention relates to a process for the control of Ostwald Ripening phenomenon occurring in particle suspensions without the need for addition of stabilizing agents, by using high pressure homogenization at mild conditions in a way that no increase or decrease in particle size occurs, thus allowing the stabilization of the suspension during the isolation step in the form of a dried powder.

Abstract: Systems and methods for shipping management in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for integrating sensors, mobile access points, and/or the network of moving things with shipping container management systems (e.g., port management systems, train management systems, trucking management systems, etc.).

Abstract: Systems and methods for shipping management in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for integrating sensors, mobile access points, and/or the network of moving things with shipping container management systems (e.g., port management systems, train management systems, trucking management systems, etc.).

Abstract: Systems and methods for managing connectivity in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for managing connectivity in a network in which at least a portion of the network access points are moving.

Abstract: Systems and methods for managing connectivity in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for managing connectivity in a network in which at least a portion of the network access points are moving.

Abstract: Systems and methods for managing mobility in a network of moving things. As non-limiting examples, various aspects of this disclosure provide systems and methods for managing mobility in a network in which at least a portion of the network access points are moving.