Abstract: Compounds of formula (1): wherein R1 represents a —C(R2)(R3)—[C(R4)(R5)]m-L-R6 group or —R7; and the preparation and the therapeutic uses of the compounds of formula (1) as agonists of TRPM8 receptors, useful especially in the treatment of oropharyngeal dysphagia.

Abstract: The present disclosure relates to a manufacturing system for additive manufacturing of a workpiece and an additive manufacturing method. The manufacturing system for additive manufacturing of a workpiece includes a building panel, a lifting device for the building panel, a blade device, an optical device, and a control unit. The blade device comprises at least one coater element for applying or removing a powder material to the building panel. The optical device comprises an optical element for reception of image data from the building panel and/or from the powder layer. The lifting device is configured to raise and/or lower the building panel. The control unit is configured to control the lifting device based on the image data.

Abstract: The present invention relates to an additive manufacturing system and an additive manufacturing method. The additive manufacturing system includes an operator area, a loading area, and a transportable container unit. The operator area is configured to control the manufacturing system. The loading area is configured for loading the manufacturing system. The operator area is accessible from a first side of the manufacturing system and the loading area is accessible from a second side of the manufacturing system, wherein the first side is different from the second side. The transportable container unit is insertable into the loading area. The transportable container unit includes a powder storage container and a building container. The powder storage container is configured to store powder, and the building container is configured to additively manufacture a workpiece.

Abstract: In the case of an objective arrangement (1) having a deflection unit (4) which guides an imaging beam path (9) from a light entrance (2) to a light exit (3) via a first reflection surface (6) and a second reflection surface (7), it is provided to embody a region (8) of total internal reflection at least in the second reflection surface (7), with this region being configured for total internal reflection in the imaging beam path (9) and this region forming part of a transmission region (5) that is disposed upstream of the first reflection surface (6), through which imaging rays from the light entrance (2) are incident on the first reflection surface (6).

Abstract: In the case of an objective arrangement (1) having a deflection unit (4) which guides an imaging beam path (9) from a light entrance (2) to a light exit (3) via a first reflection surface (6) and a second reflection surface (7), it is provided to embody a region (8) of total internal reflection at least in the second reflection surface (7), with this region being configured for total internal reflection in the imaging beam path (9) and this region forming part of a transmission region (5) that is disposed upstream of the first reflection surface (6), through which imaging rays from the light entrance (2) are incident on the first reflection surface (6).