Abstract: A method and system for magnetically tracking a device of interest generating a plurality of pre-determined multi-frequency signals. The method and system transmits a plurality of magnetic fields from a transmitter circuit based on the corresponding pre-determined multi-frequency signals. The magnetic fields propagating through an area of examination encompassing the device of interest and a magnetic sensor coupled to the device of interest. The method and system generate a sensor signal at the magnetic sensor indicative of field strength of the magnetic fields transmitted by the transmitter circuit. Further, the method and system determine a position of the magnetic sensor relative to the transmitter circuit based on the multi-frequency signals and the sensor signal.

Abstract: A method for determining depth-of-interaction correction in a PET system. The method includes modifying crystal and readout configuration to improve depth-dependent arrival profile of scintillation photons, creating a photon dispersion model within a scintillator crystal, measuring photon arrival profile of individual gamma ray event, deriving an estimated depth-of-interaction, and deriving a gamma ray event time based on a time stamp corrected with the estimated depth-of-interaction. The method further includes modeling dispersion at different depths of interaction within the scintillator crystal, providing a reflector layer to delay back-reflected photons, providing two respective readouts for the same gamma ray event from two respective pixels optically coupled by a backside reflector or modified crystal configuration, calculating a time difference of the photon arrival at the two pixels, and estimating the depth-of-interaction by applying a statistical weighting.

Abstract: Systems and methods for navigation are presented. First and second response signals received from at least one magnetic sensor operatively coupled to a target device in response to a magnetic field are measured at reference and reversed sensitivity while an alignment of magnetic domains corresponding to the magnetic sensor remains unchanged. A useful portion of the first response signal is determined by eliminating common-mode noise from the first response signal based on a difference between the first and second response signals. Alternatively, a bias signal having a desired bias frequency is applied to shift a signal frequency of a response signal of a magnetoresistance sensor that includes common-mode noise. A useful portion of the response signal is determined by measuring the response signal at a shifted frequency that is a sum of the signal and bias frequencies. A position of the subject is then determined based on the useful portion.

Abstract: Methods and systems for processing a set of images are described. In accordance with this disclosure, images are registered and an analysis is performed in view of one or more constraints (such as constraints based upon anatomical or physiological considerations). Weighting factors are determined based on the analysis. The weighting factors are used in subsequent processing of the registered (and/or unregistered) images and/or to formulate a visualization that conveys the degree of confidence in the motion estimation used in the registration process.

Abstract: Embodiments of the invention are utilized to improve the timing performance of SiPM based PET detectors with light-sharing configuration. The universal readout design utilizes adaptive group readout to process noisy and slow signals generated by SiPM devices, and provides enhanced timing capabilities with simplified readout electronics.

Abstract: A method for determining depth-of-interaction correction in a PET system includes modifying crystal and readout configuration to improve depth-dependent arrival profile of scintillation photons, creating a photon dispersion model within a scintillator crystal, measuring photon arrival profile of individual gamma ray event, deriving an estimated depth-of-interaction, and deriving a gamma ray event time based on a time stamp corrected with the estimated depth-of-interaction. The method can include modeling dispersion at different depths of interaction within the scintillator crystal; providing a reflector layer to delay back-reflected photons; providing two respective readouts for the same gamma ray event from two respective pixels optically coupled by a backside reflector or modified crystal configuration, calculating a time difference of the photon arrival at the two pixels, and estimating the depth-of-interaction by applying a statistical weighting.

Abstract: A method includes acquiring scan data for an object to be imaged using an imaging scanner. The method also includes reconstructing a display image using the scan data. Further, the method includes determining one or more aspects of a quantitation imaging algorithm for generating a quantitation image, wherein the one or more aspects of the quantitation imaging algorithm are selected to optimize a quantitation figure of merit for lesion quantitation. The method also includes reconstructing a quantitation image using the scan data and the quantitation imaging algorithm; displaying, on a display device, the display image; determining a region of interest in the display image; determining, for the region of interest, a lesion quantitation value using a corresponding region of interest of the quantitation image; and displaying, on the display device, the lesion quantitation value.

Abstract: A radiation detection system includes a detector unit and at least one processor. The detector unit is configured to generate signals responsive to radiation. The at least one processor is operably coupled to the detector unit and configured to receive the signals from the detector unit. The at least one processor is configured to obtain, during an imaging process, a first count for at least one of the signals corresponding to a first intrinsic energy window, the first energy window corresponding to values higher than an intrinsic peak value; obtain a second count for the at least one of the signals corresponding to a second intrinsic energy window, the second energy window corresponding to values lower than the intrinsic peak value; and adjust a gain applied to the signals based on at least the first count and the second count.

Abstract: In accordance with one aspect of the present system, an X-ray detector of an X-ray imaging system includes a communication module configured to receive a pre-shot image from a detection circuitry and receive one or more pre-shot parameters from a source controller of the X-ray imaging system. The X-ray detector further includes an analysis module configured to determine one or more image characteristics of the pre-shot image. The X-ray detector further includes a determination module configured to calculate one or more main-shot parameters based on the one or more pre-shot parameters and the one or more image characteristics. The determination module is further configured to send the one or more main-shot parameters to the source controller of the X-ray imaging system.

Abstract: A radiation detection system includes a detector unit and at least one processor. The detector unit is configured to generate signals responsive to radiation. The at least one processor is operably coupled to the detector unit and configured to receive the signals from the detector unit. The at least one processor is configured to obtain, during an imaging process, a first count for at least one of the signals corresponding to a first intrinsic energy window, the first energy window corresponding to values higher than an intrinsic peak value; obtain a second count for the at least one of the signals corresponding to a second intrinsic energy window, the second energy window corresponding to values lower than the intrinsic peak value; and adjust a gain applied to the signals based on at least the first count and the second count.

Abstract: A radiation detection system includes a detector unit and at least one processor. The detector unit is configured to generate signals responsive to radiation events. The at least one processor receives the signals, and is configured to obtain a first count for at least one of the signals corresponding to a first energy window, the first energy window corresponding to values higher than a nominal peak value; obtain a second count for the at least one of the signals corresponding to a second energy window, the second energy window corresponding to values lower than the nominal peak value; obtain at least one auxiliary count for the at least one of the signals corresponding to at least one auxiliary energy window; and adjust a gain applied to the signals based on the first count, the second count, and the at least one auxiliary count.

Abstract: Systems and methods for navigation are presented. First and second response signals received from at least one magnetic sensor operatively coupled to a target device in response to a magnetic field are measured at reference and reversed sensitivity while an alignment of magnetic domains corresponding to the magnetic sensor remains unchanged. A useful portion of the first response signal is determined by eliminating common-mode noise from the first response signal based on a difference between the first and second response signals. Alternatively, a bias signal having a desired bias frequency is applied to shift a signal frequency of a response signal of a magnetoresistance sensor that includes common-mode noise. A useful portion of the response signal is determined by measuring the response signal at a shifted frequency that is a sum of the signal and bias frequencies. A position of the subject is then determined based on the useful portion.

Abstract: A method and system for magnetically tracking a device of interest generating a plurality of pre-determined multi-frequency signals. The method and system transmits a plurality of magnetic fields from a transmitter circuit based on the corresponding pre-determined multi-frequency signals. The magnetic fields propagating through an area of examination encompassing the device of interest and a magnetic sensor coupled to the device of interest. The method and system generate a sensor signal at the magnetic sensor indicative of field strength of the magnetic fields transmitted by the transmitter circuit. Further, the method and system determine a position of the magnetic sensor relative to the transmitter circuit based on the multi-frequency signals and the sensor signal.

Abstract: Embodiments of systems, methods and non-transitory computer readable media for imaging are presented. Preliminary image data corresponding to a first FOV of a subject at a first resolution is acquired using an imaging system including one or more radiation sources and at least one hybrid detector, specifically using at least one section of the hybrid detector having the first resolution. The target ROI is identified using the preliminary image data. Further, the subject is positioned to align the target ROI along a designated axis. Additionally, parameters associated with the sources, the hybrid detector and/or an imaging system gantry are configured for acquiring target image data at a second resolution greater than the first resolution using at least one section of the hybrid detector having the second resolution. Further, one or more images corresponding to at least the target ROI are reconstructed using the target and/or the preliminary image data.

Abstract: In accordance with one aspect of the present system, an X-ray detector of an X-ray imaging system includes a communication module configured to receive a pre-shot image from a detection circuitry and receive one or more pre-shot parameters from a source controller of the X-ray imaging system. The X-ray detector further includes an analysis module configured to determine one or more image characteristics of the pre-shot image. The X-ray detector further includes a determination module configured to calculate one or more main-shot parameters based on the one or more pre-shot parameters and the one or more image characteristics. The determination module is further configured to send the one or more main-shot parameters to the source controller of the X-ray imaging system.

Abstract: Methods and systems for processing a set of images are described. In accordance with this disclosure, images are registered and an analysis is performed in view of one or more constraints (such as constraints based upon anatomical or physiological considerations). Weighting factors are determined based on the analysis. The weighting factors are used in subsequent processing of the registered (and/or unregistered) images and/or to formulate a visualization that conveys the degree of confidence in the motion estimation used in the registration process.

Abstract: Collimators for two-dimensional scans of a radiation sources and methods of scanning are provided. One system includes a scan unit for scanning and collecting ionizing radiation emitted from a radiation emitting object is provided. The scan unit includes an array of at least one pixelated radiation detector having an imaging surface including a two-dimensional (2D) array of pixels. The scan unit also includes a collimator positioned between the radiation detector and the radiation emitting object, with the collimator including a 2D array of columns having openings and septa forming bores, wherein the columns are arranged in groups along rows of the 2D array of columns and the bores within one of the groups have a different aspect ratios than the bores in another one of the groups.

Abstract: Methods and systems for processing a set of images are described. In accordance with this disclosure, images are registered and an analysis is performed in view of one or more constraints (such as constraints based upon anatomical or physiological considerations). Weighting factors are determined based on the analysis. The weighting factors are used in subsequent processing of the registered (and/or unregistered) images and/or to formulate a visualization that conveys the degree of confidence in the motion estimation used in the registration process.

Abstract: A motion correction system and method for motion correction for an x-ray tube is presented. One embodiment of the motion correction system includes a sensing unit coupled to an x-ray tube to determine a distance with which an impingement location of an electron beam generated by the x-ray tube deviates from a determined location due to motion of the x-ray tube. The motion correction system further includes a control unit coupled to the sensing unit to generate a control signal corresponding to the distance with which the impingement location of the electron beam deviates. Also, the motion correction system includes a deflection unit coupled to the control unit to steer the electron beam to the determined location based on the generated control signal.

Abstract: A system and method for collimation in diagnostic imaging systems is provided. One collimator includes a plurality of parallel hole segments and a plurality of collimator bores within each of the plurality of parallel hole segments. Additionally, all of the plurality of collimator bores in at least one of the plurality of parallel hole segments have a first pointing direction and all of the plurality of collimator bores in at least one other of the plurality of parallel hole segments have a second pointing direction, wherein the plurality of parallel hole segments are arranged in a fanbeam collimation configuration. Further, the first pointing direction is different than the second pointing direction.