Patents by Inventor Florin M. Selaru
Florin M. Selaru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240157101Abstract: The present disclosure provides microscale devices, systems, and methods thereof for the delivery of therapeutic and prophylactic active agents (e.g., macromolecules).Type: ApplicationFiled: March 18, 2022Publication date: May 16, 2024Inventors: David H. Gracias, Florin M. Selaru, Arijit Ghosh
-
Publication number: 20240131006Abstract: The present disclosure provides methods, uses, and pharmaceutical compositions comprising and azole derivative (e.g., sulconazole) in the treatment or prevention of fibrotic disease or disorder or fibrosis, including Crohn's disease.Type: ApplicationFiled: March 1, 2022Publication date: April 25, 2024Inventors: Florin M. Selaru, Laura Ensign-Hodges, Ling Li, Min Kyung Joo
-
Publication number: 20230074885Abstract: The presently disclosed subject matter provides nanoparticles comprising bortezomib encapsulated in a non-water-soluble polymer matrix in a form of a bortezomib-tannic acid complex; methods for preparing the nanoparticle; and use of the nanoparticles for treating liver cancer.Type: ApplicationFiled: February 5, 2021Publication date: March 9, 2023Inventors: Florin M. Selaru, Hai-Quan Mao, Ling Li, Yang Zhou, Zhiyu He, Kuntao Chen
-
Publication number: 20220226342Abstract: Described herein are methods for treating liver tumors and cancer in a subject comprising the steps of administering a suppressor of protein translation to a subject in need thereof. Examples of liver cancer include hepatocellular carcinoma (HCC), cholangiocarcinoma, or a combination thereof. Examples of a suppressor of protein translation includes omacetaxine mepusuccinate, and the methods include combinations with other chemotherapeutic agents.Type: ApplicationFiled: June 29, 2020Publication date: July 21, 2022Inventors: Florin M. Selaru, Ling Li
-
Patent number: 11149275Abstract: Described are devices for treating disease in subjects wherein the devices include a sponge comprising a hydrogel, extracellular vesicles (EVs), and an agent. Methods of using the devices to treat or prevent disease such as esophageal adenocarcinoma are also described.Type: GrantFiled: October 9, 2017Date of Patent: October 19, 2021Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Florin M. Selaru, Stephen J. Meltzer, George L. Coles, Honggang Cui
-
Publication number: 20200345867Abstract: Intrabiliary hydrodynamic injection of nucleic acid for in vivo gene therapy for treatment of liver or pancreas disease and other disorders.Type: ApplicationFiled: April 30, 2020Publication date: November 5, 2020Inventors: Florin M. Selaru, Vivek Kumbhari, Ling Li
-
Patent number: 10722221Abstract: The present invention utilizes tetherless microtools to biopsy tissue. The invention provides a device and method for deployment and retrieval of tetherless microtools. The size of the microtools ensures that tissue damage at a site targeted for biopsy is negligible. As such, large numbers of microtools may be deployed ensuring that a true statistical sampling of biologic tissue is performed.Type: GrantFiled: July 31, 2017Date of Patent: July 28, 2020Assignee: The Johns Hopkins UniversityInventors: Anthony N. Kalloo, David H. Gracias, Florin M. Selaru, Evin Gultepe, Mouen A. Khashab
-
Publication number: 20200197535Abstract: The present invention relates to the field of extracellular vesicles. More specifically, the present invention provides methods and compositions for using extracellular vesicles as a vector for nucleic acid treatment in vivo of various diseases. In a specific embodiment, the present invention provides an extracellular vesicle isolated from a cell comprising one or more microRNAs (miRNAs) that have been loaded ex vivo into the vesicle so that the miRNAs are present in a higher concentration than when measured in the same extracellular vesicle isolated directly from the cell. In another embodiment, the present invention provides a method for treating cholangiocarcinoma in a subject comprising the step of administering to the subject a plurality of exosomes comprising miR-195.Type: ApplicationFiled: November 11, 2019Publication date: June 25, 2020Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: FLORIN M. SELARU, LING LI, STEPHEN J. GOULD
-
Patent number: 10493165Abstract: The present invention relates to the field of extracellular vesicles. More specifically, the present invention provides methods and compositions for using extracellular vesicles as a vector for nucleic acid treatment in vivo of various diseases. In a specific embodiment, the present invention provides an extracellular vesicle isolated from a cell comprising one or more microRNAs (miRNAs) that have been loaded ex vivo into the vesicle so that the miRNAs are present in a higher concentration than when measured in the same extracellular vesicle isolated directly from the cell. In another embodiment, the present invention provides a method for treating cholangiocarcinoma in a subject comprising the step of administering to the subject a plurality of exosomes comprising miR-195.Type: GrantFiled: January 29, 2016Date of Patent: December 3, 2019Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Florin M. Selaru, Ling Li, Stephen J. Gould
-
Patent number: 10441760Abstract: The presently disclosed delivery systems utilize microtools, also referred to as theragrippers, to deliver a drug or other therapeutic agent to targeted tissue. More particularly, the drug delivery system and methods provide a delivery system that is capable of anchoring to a tissue site and then delivering a drug or therapeutic agent to the tissue directly to or in the vicinity of the site over an extended period of time. Any number of theragrippers may be deployed as desired to deliver different doses of a desired drug or therapeutic agent. The theragrippers also can be biodegradable such that they remain in place for an extended period of time and then degrade without adversely affecting the surrounding tissue.Type: GrantFiled: March 3, 2014Date of Patent: October 15, 2019Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Florin M. Selaru, David H. Gracias, Joyce Breger
-
Publication number: 20180179543Abstract: Described are devices for treating disease in subjects wherein the devices include a sponge comprising a hydrogel, extracellular vesicles (EVs), and an agent. Methods of using the devices to treat or prevent disease such as esophageal adenocarcinoma are also described.Type: ApplicationFiled: October 9, 2017Publication date: June 28, 2018Inventors: Florin M. Selaru, Stephen J. Meltzer, George L. Coles, Honggang Ciu
-
Publication number: 20180028687Abstract: The present invention relates to the field of extracellular vesicles. More specifically, the present invention provides methods and compositions for using extracellular vesicles as a vector for nucleic acid treatment in vivo of various diseases. In a specific embodiment, the present invention provides an extracellular vesicle isolated from a cell comprising one or more microRNAs (miRNAs) that have been loaded ex vivo into the vesicle so that the miRNAs are present in a higher concentration than when measured in the same extracellular vesicle isolated directly from the cell. In another embodiment, the present invention provides a method for treating cholangiocarcinoma in a subject comprising the step of administering to the subject a plurality of exosomes comprising miR-195.Type: ApplicationFiled: January 29, 2016Publication date: February 1, 2018Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: FLORIN M. SELARU, LING LI, STEPHEN J. GOULD
-
Publication number: 20180028165Abstract: The present invention utilizes tetherless microtools to biopsy tissue. The invention provides a device and method for deployment and retrieval of tetherless microtools. The size of the microtools ensures that tissue damage at a site targeted for biopsy is negligible. As such, large numbers of microtools may be deployed ensuring that a true statistical sampling of biologic tissue is performed.Type: ApplicationFiled: July 31, 2017Publication date: February 1, 2018Inventors: Anthony N. Kalloo, David H. Gracias, Florin M. Selaru, Evin Gultepe, Mouen A. Khashab
-
Patent number: 9717484Abstract: The present invention utilizes tetherless microtools to biopsy tissue. The invention provides a device and method for deployment and retrieval of tetherless microtools. The size of the microtools ensures that tissue damage at a site targeted for biopsy is negligible. As such, large numbers of microtools may be deployed ensuring that a true statistical sampling of biologic tissue is performed.Type: GrantFiled: May 3, 2012Date of Patent: August 1, 2017Assignee: The Johns Hopkins UniversityInventors: Anthony N. Kalloo, David H. Gracias, Florin M. Selaru, Evin Gultepe, Mouen A. Khashab
-
Publication number: 20140249499Abstract: The presently disclosed delivery systems utilize microtools, also referred to as theragrippers, to deliver a drug or other therapeutic agent to targeted tissue. More particularly, the drug delivery system and methods provide a delivery system that is capable of anchoring to a tissue site and then delivering a drug or therapeutic agent to the tissue directly to or in the vicinity of the site over an extended period of time. Any number of theragrippers may be deployed as desired to deliver different doses of a desired drug or therapeutic agent. The theragrippers also can be biodegradable such that they remain in place for an extended period of time and then degrade without adversely affecting the surrounding tissue.Type: ApplicationFiled: March 3, 2014Publication date: September 4, 2014Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Florin M. Selaru, David H. Gracias, Joyce Breger
-
Publication number: 20140207019Abstract: The present invention utilizes tetherless microtools to biopsy tissue. The invention provides a device and method for deployment and retrieval of tetherless microtools. The size of the microtools ensures that tissue damage at a site targeted for biopsy is negligible. As such, large numbers of microtools may be deployed ensuring that a true statistical sampling of biologic tissue is performed.Type: ApplicationFiled: May 3, 2012Publication date: July 24, 2014Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Anthony N. Kalloo, David H. Gracias, Florin M. Selaru, Evin Gultepe, Mouen A. Khashab
-
Publication number: 20140206565Abstract: The present invention is directed to methods for diagnosing cancer in a subject. Morphologically normal epithelial cells of the esophagus are assayed for marker expression. Characteristic expression of the markers indicates the presence of cancer or the predisposition to cancer. A panel of eleven markers are particularly good at identifying cancer and the predisposition to cancer.Type: ApplicationFiled: February 5, 2014Publication date: July 24, 2014Applicants: University of Maryland, Baltimore, The Johns Hopkins UniversityInventors: Florin M. SELARU, Stephen J. MELTZER
-
Patent number: 8679759Abstract: The present invention is directed to methods for diagnosing cancer in a subject. Morphologically normal epithelial cells of the esophagus are assayed for marker expression. Characteristic expression of the markers indicates the presence of cancer or the predisposition to cancer. A panel of eleven markers are particularly good at identifying cancer and the predisposition to cancer.Type: GrantFiled: July 31, 2008Date of Patent: March 25, 2014Assignees: The Johns Hopkins University, University of Maryland, BaltimoreInventors: Florin M. Selaru, Stephen J. Meltzer
-
Publication number: 20100285466Abstract: The present invention is directed to methods for diagnosing cancer in a subject. Morphologically normal epithelial cells of the esophagus are assayed for marker expression. Characteristic expression of the markers indicates the presence of cancer or the predisposition to cancer. A panel of eleven markers are particularly good at identifying cancer and the predisposition to cancer.Type: ApplicationFiled: July 31, 2008Publication date: November 11, 2010Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Florin M. Selaru, Stephen J. Meltzer