Abstract: A dissolvable stretch ring including a biodegradable polymer positioned on or adjacent to at least one haptic of an intraocular lens (IOL) is described. The dissolvable stretch ring can be included in an IOL arrangement, comprising an IOL an IOL body and at least one haptic extending directly or indirectly from the IOL body, and the dissolvable stretch ring. A method of implanting an IOL into an eye of a subject including the steps of inserting an IOL comprising an IOL body and at least one haptic extending directly or indirectly from the IOL body into the capsular bag of the eye and positioning a dissolvable stretch ring comprising a biodegradable polymer on at least one haptic of the IOL is also described.

Abstract: A polymer ring configured to fit around or adjacent to an intraocular lens is described. The polymer ring comprises a hyaluronic acid derivative and a drug. An intraocular lens comprising a polymer ring positioned on or adjacent to the intraocular lens is also described. In addition, a method of delivering a drug to an eye of a subject is described. The method includes inserting an intraocular lens into the eye of the subject, and positioning polymer ring onto at least a portion of the intraocular lens, wherein the polymer ring comprises a hyaluronic acid derivative and a drug.

Abstract: An insertion system for inserting an IOL int a patient's eye is provided. The insertion system includes a pusher and an introducer sheath with a back housing and a front housing. The front housing includes a longitudinally extending IOL rolling member with a proximal section, an intermediate section, a distal section and a longitudinally extending lumen defined by an upper face and a lower face. The lower face has opposing inner peripheral edges. The radius of curvature of the upper face and the lower face decreases from the proximal section to the distal section and the distance between the opposing inner peripheral edges decreases from the proximal section to the distal section.

Abstract: A two-piece intraocular lens (IOL) with an anterior shape-changing optic is provided. The shape-changing interchangeable optic includes an elastic anterior face located anterior to the equator and comprising anterior arms releasably connected to actuating haptics of a base.

Abstract: An insertion system for inserting an IOL int a patient's eye is provided. The insertion system includes a pusher and an introducer sheath with a back housing and a front housing. The front housing includes a longitudinally extending IOL rolling member with a proximal section, an intermediate section, a distal section and a longitudinally extending lumen defined by an upper face and a lower face. The lower face has opposing inner peripheral edges. The radius of curvature of the upper face and the lower face decreases from the proximal section to the distal section and the distance between the opposing inner peripheral edges decreases from the proximal section to the distal section.

Abstract: An intraocular lens (IOL) with a shape-changing optic is provided. The shape-changing optic includes an elastic anterior face located anterior to the equator. The anterior face has an anterior surface, a posterior surface, and a periphery. The shape-changing optic also includes a posterior face having an anterior surface, a posterior surface, and a periphery. An elastic side wall can extend across the equator and extend from the anterior face to the posterior face. A chamber can be located between the anterior face and the posterior face. The IOL can further include at least one haptic extending from the periphery of the anterior face, the periphery of the posterior face, or both.

Abstract: An intraocular lens (IOL) with a shape-changing optic is provided. The shape-changing optic includes an elastic anterior face located anterior to the equator. The anterior face has an anterior surface, a posterior surface, and a periphery. The shape-changing optic also includes a posterior face having an anterior surface, a posterior surface, and a periphery. An elastic side wall can extend across the equator and extend from the anterior face to the posterior face. A chamber can be located between the anterior face and the posterior face. The IOL can further include at least one haptic extending from the periphery of the anterior face, the periphery of the posterior face, or both.

Abstract: An intraocular lens (IOL) with a shape-changing optic is provided. The shape-changing optic includes an elastic anterior face located anterior to the equator. The anterior face has an anterior surface, a posterior surface, and a periphery. The shape-changing optic also includes a posterior face having an anterior surface, a posterior surface, and a periphery. An elastic side wall can extend across the equator and extend from the anterior face to the posterior face. A chamber can be located between the anterior face and the posterior face. The IOL can further include at least one haptic extending from the periphery of the anterior face, the periphery of the posterior face, or both.

Abstract: An intraocular lens (IOL) having an optical axis extending in an anterior-posterior direction and an equator extending in a plane substantially perpendicular to the optical axis is described. The IOL includes: an elastic anterior face located anterior to the equator; a posterior face located posterior to the equator, wherein the anterior face, the posterior face, or both comprises a poly(dimethylsiloxane) elastomer having a durometer between about 20 Shore A to about 50 Shore A; and a chamber located between the anterior face and the posterior face comprising a silicone oil comprising polysiloxanes comprising diphenyl siloxane and dimethyl siloxane units, the silicone oil having a maximum viscosity of about 800 cSt at 25° C.

Abstract: An intraocular lens (IOL) with a shape-changing optic is provided. The IOL includes an anterior face and/or a posterior face that is fabricated from a poly(dimethylsiloxane) elastomer having a durometer between about 30 Shore A to about 50 Shore A. A chamber is located between the anterior face and the posterior face and includes a silicone oil including diphenyl siloxane and dimethyl siloxane units. The silicone oil has a maximum viscosity of about 700 mm2/s at 25° C. and has a mean molecular weight of less than about 3,000 Daltons. An IOL is also provided that includes an anterior face and/or posterior face that is fabricated from a polysiloxane that is at least 99% poly(dimethylsiloxane) elastomer.

Abstract: An intraocular lens (IOL) having an optical axis extending in an anterior-posterior direction and an equator extending in a plane substantially perpendicular to the optical axis is described. The IOL includes: an elastic anterior face located anterior to the equator; a posterior face located posterior to the equator, wherein the anterior face, the posterior face, or both comprises a poly(dimethylsiloxane) elastomer having a durometer between about 20 Shore A to about 50 Shore A; and a chamber located between the anterior face and the posterior face comprising a silicone oil comprising polysiloxanes comprising diphenyl siloxane and dimethyl siloxane units, the silicone oil having a maximum viscosity of about 800 cSt at 25° C.

Abstract: An intraocular lens (IOL) having an optical axis extending in an anterior-posterior direction and an equator extending in a plane substantially perpendicular to the optical axis is described. The IOL includes: an elastic anterior face located anterior to the equator; a posterior face located posterior to the equator, wherein the anterior face, the posterior face, or both comprises a poly(dimethylsiloxane) elastomer having a durometer between about 20 Shore A to about 50 Shore A; and a chamber located between the anterior face and the posterior face comprising a silicone oil comprising polysiloxanes comprising diphenyl siloxane and dimethyl siloxane units, the silicone oil having a maximum viscosity of about 800 cSt at 25° C.

Abstract: An intraocular lens (IOL) with a shape-changing optic is provided. The IOL includes an anterior face and/or a posterior face that is fabricated from a poly(dimethylsiloxane) elastomer having a durometer between about 30 Shore A to about 50 Shore A. A chamber is located between the anterior face and the posterior face and includes a silicone oil including diphenyl siloxane and dimethyl siloxane units. The silicone oil has a maximum viscosity of about 700 mm2/s at 25° C. and has a mean molecular weight of less than about 3,000 Daltons. An IOL is also provided that includes an anterior face and/or posterior face that is fabricated from a polysiloxane that is at least 99% poly(dimethylsiloxane) elastomer.

Abstract: An intraocular lens (IOL) having an optical axis extending in an anterior-posterior direction and an equator extending in a plane substantially perpendicular to the optical axis is described. The IOL includes: an elastic anterior face located anterior to the equator; a posterior face located posterior to the equator, wherein the anterior face, the posterior face, or both comprises a poly(dimethylsiloxane) elastomer having a durometer between about 20 Shore A to about 50 Shore A; and a chamber located between the anterior face and the posterior face comprising a silicone oil comprising polysiloxanes comprising diphenyl siloxane and dimethyl siloxane units, the silicone oil having a maximum viscosity of about 800 cSt at 25° C.

Abstract: An accommodating intraocular lens (IOL) is provided. The IOL includes an optic having an anterior face and a posterior face. One or more centration lips are disposed directly on the posterior and/or anterior face of the optic or directly on the posterior and/or anterior face of a carrier that holds the optic. Anterior centration lips are configured to center the optic in a lens capsulotomy opening. Posterior centration lips are configured to fixate the optic in a lens capsule and also center the optic in a lens capsulotomy opening.

Abstract: An intraocular lens (IOL) with a shape-changing optic is provided. The shape-changing optic includes an elastic anterior face located anterior to the equator. The anterior face has an anterior surface, a posterior surface, and a periphery. The shape-changing optic also includes a posterior face having an anterior surface, a posterior surface, and a periphery. An elastic side wall can extend across the equator and extend from the anterior face to the posterior face. A chamber can be located between the anterior face and the posterior face. The IOL can further include at least one haptic extending from the periphery of the anterior face, the periphery of the posterior face, or both.

Abstract: An accommodating intraocular lens (IOL) is provided. The IOL includes an optic having an anterior face and a posterior face. One or more centration lips are disposed directly on the posterior and/or anterior face of the optic or directly on the posterior and/or anterior face of a carrier that holds the optic. Anterior centration lips are configured to center the optic in a lens capsulotomy opening. Posterior centration lips are configured to fixate the optic in a lens capsule and also center the optic in a lens capsulotomy opening.

Abstract: An improved cutter assembly is used to form an aperture in a lens capsule of an eye. The cutter assembly is resiliently deflectable between a contracted condition and an expanded condition. When the cutter assembly is in the contracted condition, it is moved through an opening in the eye into alignment with an anterior portion of lens capsule of the eye. The cutter assembly is then operated to the expanded condition and moved against the anterior portion of the lens capsule under the influence of fluid pressure. To move the cutter assembly against the anterior portion of the lens capsule, a seal engages an anterior portion of the lens capsule and a conduit connected with the cutter assembly is connected in fluid communication with a source of low pressure (vacuum).