Abstract: Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

Abstract: Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

Abstract: This invention is directed to a method for treating a host, especially a human, infected with hepatitis C, flavivirus and/or pestivirus, comprising administering to that host an effective amount of an anti-HCV biologically active pentofuranonucleoside where the pentofuranonucleoside base is an optionally substituted 2-azapurine. The optionally substituted pentofuranonucleoside, or a salt or prodrug thereof, may be administered alone or in combination with one or more optionally substituted pentofuranonucleosides or other anti-viral agents.

Abstract: Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, pharmaceutical compositions comprising such compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

Abstract: The present invention relates to the cosmetic use of at least one compound of general formula (I): in which: X represents a radical chosen from the groups: with R1, R2 and R3 representing, independently of each other, a hydrogen atom, an OH group or a radical R with R as defined below, R represents an alkyl radical, a polyfluoroalkyl or perfluoroalkyl radical or an aryl radical, S represents a monosaccharide or a polysaccharide comprising up to 20 sugar units, in pyranose and/or furanose form and of L and/or D series, and the bond S—C represents a bond of C-anomeric nature, or a salt or isomer thereof, for increasing the mechanical strength of keratin fibers.

Abstract: The invention relates to a method of generating a synthesized image of a hair, comprising the following steps: calculating the shape of the hair by applying a behavioral relationship determining the shape of the hair as a function of a physical parameter linked to a mechanical property of the hair, in particular the linear density; producing an image of the hair of shape that has been calculated in this way. The behavioral relationship may be given by the minimization of the following function: E = K L ? ? 0 1 ? [ 1 2 ? ( k ~ ? ( s ~ ) - ? ) 2 + 1 ? ? z ~ ? ( s ~ ) ] ? ? s ~ , where ?=Lk0 and ?=K/g?L3, and where L designates the length of the hair, k0 its spontaneous curvature, K its bending moment, ? its linear density and g the acceleration due to gravity, {tilde over (s)} the curvilinear abscissa relative to the length of the hair, {tilde over (k)} its local curvature relative to its length and {tilde over (z)} its height relative to its length.

Abstract: The present invention provides nucleoside analogue compounds that treat a host infected with a Flaviviridae virus infection, or other viruses that exhibit RNA-dependent RNA viral replication, compositions comprising these compounds and methods of using the compounds for the treatment and/or prophylaxis of viral infection, especially hepatitis C, in an infected host.

Abstract: The present invention relates to the use of polyols of formula (I): or a salt thereof, for preventing the hair from breaking. The invention also relates to a cosmetic composition comprising at least one such polyol or a salt thereof, in a cosmetically acceptable medium, and also to a cosmetic hair treatment process using the said composition.

Abstract: This invention is directed to a method for treating a host, especially a human, infected with hepatitis C, flavivirus and/or pestivirus, comprising administering to that host an effective amount of an anti-flavivirus or anti-pestivirus, biologically active compound has a 5-aza-7-deazapurine moiety. The 5-aza-7-deazapurine moiety may be substituted or unsubstituted, and may comprise a nucleoside analogue, or a salt or prodrug thereof. The compound of the present invention may be administered alone or in combination with another anti-hepatitis C, anti-flavivirus and/or anti-pestivirus agent.

Abstract: The invention concerns a method for treating hair keratin fibers to provide them with new appropriate properties, comprising the following steps: reducing the sulphur bonds of hair keratin to generate only at the surface of the fibers at a depth less than 10 ?m. reactive sites and in fixing covalently on said reactive sites at least one active compound for providing the hair keratin fibers with new appropriate properties, said active compound containing at least a reactive function capable of reacting with said reactive sites formed at the keratin fiber surface. This method is applicable to the treatment of fibrous or non-fibrous keratin substances of human or animal origin.

Abstract: This invention is directed to a method for treating a host, especially a human, infected with hepatitis C, flavivirus and/or pestivirus, comprising administering to that host an effective amount of an anti-HCV biologically active pentofuranonucleoside where the pentofuranonucleoside base is an optionally substituted 2-azapurine. The optionally substituted pentofuranonucleoside, or a salt or prodrug thereof, may be administered alone or in combination with one or more optionally substituted pentofuranonucleosides or other anti-viral agents.

Abstract: The invention concerns a method for treating hair keratin fibers to provide them with new appropriate properties, comprising the following steps: reducing the sulphur bonds of hair keratin to generate only at the surface of the fibers at a depth less than 10 &mgr;m. reactive sites and in fixing covalently on said reactive sites at least one active compound for providing the hair keratin fibers with new appropriate properties, said active compound containing at least a reactive function capable of reacting with said reactive sites formed at the keratin fiber surface. This method is applicable to the treatment of fibrous or non-fibrous keratin substances of human or animal origin.

Abstract: The invention concerns a method for treating hair keratin fibers to provide them with new appropriate properties, comprising the following steps: reducing the sulphur bonds of hair keratin to generate only at the surface of the fibers at a depth less than 10 &mgr;m. reactive sites and in fixing covalently on said reactive sites at least one active compound for providing the hair keratin fibers with new appropriate properties, said active compound containing at least a reactive function capable of reacting with said reactive sites formed at the keratin fiber surface. This method is applicable to the treatment of fibrous or non-fibrous keratin substances of human or animal origin.

Abstract: According to the process for applying reshaping to hair by use of a hair-curler, the hair-curler (1) is arranged in such a way that the perimeter along which the lock of hair (M) is rolled increases by approx. 2 to 3% when its temperature rises to pass from a starting temperature to a higher temperature which nevertheless remains lower than a relatively low limit thus avoiding the burning of the hair and/or of the scalp; the longitudinal section of the curler is sufficient to withstand the stresses imposed by elongation of the lock of hair; the lock of hair is rolled around the curler at the starting temperature so that the hair is retained against the hair-curler; the curler is raised to the said higher temperature; the hair is thus subjected to elongation ensuring an increase in the life of the reshaping applied to the hair.

Abstract: The device for the compression of a gas comprises a motor (1), a piston (2) adapted to be displaced linearly in a pump body, transmission means (T) between the motor (1) and the piston (2) adapted to convert the rotary motion generated by the motor (1) into a reciprocating translatory motion by the piston (2). Speed varying means comprising a cam (12) are provided to impart a different speed to the piston (2) of the compressor according to the resistance opposing the motor (1) during one complete admission/compression cycle, so that the resisting torque is substantially constant and so that the motor (1) operates at its maximum torque and therefore at maximum efficiency. The section of the cam (12) is determined so as to ensure substantially isothermal compression of the gas.

Abstract: Device for the compression and storage of air comprising, on the one hand, a reservoir (1) provided with an air discharge head (5) intended for cooperation with a container to be charged with compressed air and, on the other hand, at least one compression chamber (C1), associated with air inlet valves (19) and air ejection valves (15) and with a compression element actuated by a motor means (13) compressing the volume of the chamber (C1) between a maximum volume and a minimum volume, the ratio between the maximum volume and the minimum volume of the said chamber (C1) being from 1.2 to 20.