Abstract: The need to identify new therapeutic approaches in the treatment of cancers of the B lymphoid lineage is crucial. Here, the inventors provide evidence for efficient knockdown of c-REL and RELA expression after treatment with splice switching antisense oligonucleotides (SSO) inducing exon skipping and reading frameshift. For instance, treatments with morpholino SSO targeting c-REL exon 2 donor splice site or RELA exon 5 acceptor splice site elicited very efficient knockdown in diffuse large B cell lymphoma (DLBCL) cell lines and antibody-secreting cells derived from primary human B cells. Consistent with the clinical relevance of c-REL activation in DLBCL, treatment with c-REL SSO induced major alterations in NF-?B and TNF signalling pathways and strongly decreased cell viability. Altogether, SSO-mediated knockdown is a powerful approach to inhibit transiently the expression of a NF-?B component in B-lineage cells that should open new avenues for cancer treatments.

Abstract: A steam exchange humidifier comprising a heat exchanger inside a tank, the tank comprising a drain and fluid inlet port for fluid in and out of the tank and a steam outlet; the heat exchanger comprising a heat exchanger array, a steam collector, a condensate collector, a steam supply port and condensate return port; the steam collector being connected to the steam supply port, and the condensate collector being connected to the condensate return port; the steam collector and the condensate collector being connected by the heat exchanger array, wherein the tank is a generally vertical body.

Abstract: A steam generator and a method for generating steam, the generator comprising a steam chamber fed with water from a water from a water reservoir for heating by a heating source to generate steam, steam being delivered out through a steam outlet, and waste water being evacuated through a drain, the steam generator comprising a control chamber, in fluid communication with the steam chamber so as that a water level in the control chamber is indicative of a water level in said steam chamber; at least one water level-sensor configured for detecting the water level in the control chamber; and a control unit receiving a signal from the water level-sensor. There is further provided a method of generating steam in a steam chamber receiving Water is fed from the water reservoir simultaneously to the steam chamber and to the control chamber, through a single feeding valve, the feed water being mixed with hot waste water drained from the steam chamber, upstream of a drain pump.

Abstract: A method for generating data of interest relating to a geographical zone, by an item of computing equipment, on the basis of a datum and of a geographical position originating from a transmission (Tr1) by a transmission unit (122), includes making a vehicle (104) travel around a predetermined path (T1) of the geographical zone at a temporal frequency, the transmission unit being embedded on board the vehicle transmitting to the item of computing equipment the datum and a geographical position, the geographical position corresponding to the geographical position of a sensor (106) embedded on board the vehicle, while the vehicle is travelling around the path, at the moment of a generation of a value (108) of a physical quantity in a monitoring zone (112) outside the vehicle, the datum being generated by a processing, by a processing unit (114) embedded on board the vehicle, of the value.

Abstract: A steam generator and a method for generating steam, the generator comprising a steam chamber fed with water from a water from a water reservoir for heating by a heating source to generate steam, steam being delivered out through a steam outlet, and waste water being evacuated through a drain, the steam generator comprising a control chamber, in fluid communication with the steam chamber so as that a water level in the control chamber is indicative of a water level in said steam chamber; at least one water level-sensor configured for detecting the water level in the control chamber; and a control unit receiving a signal from the water level-sensor. There is further provided a method of generating steam in a steam chamber receiving Water is fed from the water reservoir simultaneously to the steam chamber and to the control chamber, through a single feeding valve, the feed water being mixed with hot waste water drained from the steam chamber, upstream of a drain pump.

Abstract: This dosing device (1) comprises a container (2) and a plug (4) comprising, in addition to a part (15) for connection to the container, two mobile outer parts (16 and 17). One of the mobile parts (16) is held in place during dosing, while the container (2) rotates continually to assist the flow of the content of same; the other outer part (17) can be rotated as necessary to adjust the opening of the plug. The movements can be carried out by a machine on which the dosing device is positioned upside down, with the plug facing downwards.

Abstract: The invention relates to a sizing composition intended to be applied to mineral fibers, especially glass or rock fibers, which contains at least one polycarboxylic acid and at least one polyamine. It also relates to a method of preparing the composition, to its use for sizing mineral fibers for the purpose of forming, in particular, thermal and/or acoustic insulation products, and to the products obtained.

Abstract: The invention relates to a sizing composition intended to be applied to mineral fibers, especially glass or rock fibers, which contains at least one polycarboxylic acid and at least one polyamine. It also relates to a method of preparing said composition, to its use for sizing mineral fibers for the purpose of forming, in particular, thermal and/or acoustic insulation products, and to the products obtained.

Abstract: The invention relates to a sizing composition intended to be applied to mineral fibers, especially glass or rock fibers, which contains at least one polycarboxylic acid and at least one polyamine. It also relates to a method of preparing said composition, to its use for sizing mineral fibers for the purpose of forming, in particular, thermal and/or acoustic insulation products, and to the products obtained.

Abstract: The invention concerns a device comprising an electronic sensor (6) designed to deliver a compression signal and a shearing signal, and a comparator for comparing the shearing signal to a threshold value, so as to validate, or invalidate, the compression signal. The invention is useful for weighing aircraft.

Abstract: The invention concerns a device comprising an electronic sensor (6) designed to deliver a compression signal and a shearing signal, and a comparator for comparing the shearing signal to a threshold value, so as to validate, or invalidate, the compression signal. The invention is useful for weighing aircraft.

Abstract: A process for preparing a controlled release medicine containing fenofibrate in an intermediate layer in the form of cyrstalline microparticles included within pores of an inert matrix prepared by a process involving the sequential steps of dampening said inert core with a solution based on said biner, then projecting said fenofibrate microparticles in a single layer onto said dampened core, and thereafter drying before said solution based on said binder dissolves said fenofibrate microparticles and repeating said three steps in sequence until said intermediate layer is formed.

Abstract: The slow release preparation obtained by the method of the invention reduces the number of times the medicine needs to be taken per day, and also provides lower peaks of concentration in the blood after the medicine has been taken while simultaneously ensuring that the lowest concentration in the blood remains higher over a period of time.

Abstract: A granular medicine based on fenofibrate, each granule comprising an inert core, a layer based on fenofibrate, and a protective layer, the medicine being characterized in that the fenofibrate in the layer based on fenofibrate is present in the form of crystalline microparticles of dimensions not greater than 30 microns, and preferably less than 10 microns.

Abstract: The slow release preparation obtained by the method of the invention reduces the number of times the medicine needs to be taken per day, and also provides lower peaks of concentration in the blood after the medicine has been taken while simultaneously ensuring that the lowest concentration in the blood remains higher over a period of time.