Abstract: A low-pressure powder injection molding machine, a kit and a method thereof. The machine has a feedstock container adapted to contain mixed feedstock, a mold and an injection device. The mold has an inlet and a cavity in which the feedstock material can set. The injection device has an injection port for supplying the mixed feedstock from the container to the mold by using pressure. The machine also has a moveable platform adapted to provide movement between the injection port of the injection device and the inlet of the mold in order to directly communicate the feedstock between the injection port and the inlet without using an intermediate conduit and thereby preventing any feedstock from setting or dissociating between the injection port and the inlet.

Abstract: A low-pressure powder injection molding machine, a kit and a method thereof. The machine has a feedstock container adapted to contain (mixed feedstock, a mold and an injection device. The mold has an inlet and a cavity in which the feedstock material can set. The injection device has an injection port for supplying the mixed feedstock from the container to the mold by using pressure. The machine also has a moveable platform adapted to provide movement between the injection port of the injection device and the inlet of the mold in order to directly communicate the feedstock between the injection port and the inlet without using an intermediate conduit and thereby preventing any feedstock from setting or dissociating between the injection port and the inlet.

Abstract: Pipeline information regarding real estate construction jobs may be obtained from a data feed. A new real estate development associated with a specified job type, and a building identification number for the new real estate development may be identified from the pipeline information. Additional information regarding the new real estate development may be obtained by sending a query that includes the building identification number to a data source. A geographic area and a unit type associated with the new real estate development may be determined based on information regarding the new real estate development. User data may be analyzed to identify a user interested in pipeline information associated with the geographic area and the unit type. An electronic message regarding the new real estate development may be sent to the user.

Abstract: The invention relates to an imaging system and an associated device for detecting a sample (4). The imaging system comprises a matrix (24) of photosensors (26), a first lamina (28) disposed opposite the matrix (24) of photosensors defining a face (28A) for supporting the sample, and a set (30) of optical elements, disposed between the matrix (24) of photosensors and the first lamina (28). Each microlens (34) is disposed above a photosensor (26) of the matrix (24) of photosensors. The set (30) of optical elements comprises a matrix (32) of microlenses (34). The set (30) of optical elements comprises an optical medium (36) disposed between the matrix (32) of microlenses and the first lamina (28), the refractive index of the optical medium (36) being substantially between 1 and the refractive index of the microlenses (34).

Abstract: The invention relates to an imaging system and an associated device for detecting a sample (4). The imaging system comprises a matrix (24) of photosensors (26), a first lamina (28) disposed opposite the matrix (24) of photosensors defining a face (28A) for supporting the sample, and a set (30) of optical elements, disposed between the matrix (24) of photosensors and the first lamina (28). Each microlens (34) is disposed above a photosensor (26) of the matrix (24) of photosensors. The set (30) of optical elements comprises a matrix (32) of microlenses (34). The set (30) of optical elements comprises an optical medium (36) disposed between the matrix (32) of microlenses and the first lamina (28), the refractive index of the optical medium (36) being substantially between 1 and the refractive index of the microlenses (34).

Abstract: The invention relates to a method for functionalising at least a portion of a wall of a pore of a carrier material, characterised in that it comprises: a) contacting the pore with a solution of electrically activated entities and positioning two electrodes in said solution in order to create inside the pore, and when an electric signal is applied between the two electrodes, a voltage drop capable of generating a localised deposit on said wall; and b) applying an electric signal between the two electrodes in order to activate the electrically activated entities and carry out said functionalisation function.

Abstract: A method and device for analysis of reaction media containing one or more cells. This method and device can be used to perform an automated high-throughput analysis.

Abstract: A device for measuring electrical activity of biological elements, including a substrate that has lower and upper faces and at least one through opening, the opening being delimited by a set of walls. Two plates are placed on either side of the lower and upper faces of the substrate and delimit, with the set of walls, a chamber. Each of the plates is provided, on its face lying opposite the substrate, with at least one electrode facing the opening in the substrate. Each of the plates further has at least one channel that starts inside the chamber and connects the chamber to the outside of the device, and the chamber communicates with the outside of the device only through the channels.

Abstract: The invention relates to a dispensing device for droplets comprising a first channel (8, 10), known as main channel, for circulation of a first fluid flow, a second channel (12, 13) for circulation of fluid, which forms with the first channel an intersection zone (27) and terminates in an ejection orifice (20), means (4) for measuring a physical property particles or cells in the first channel (18), and means for engendering a pressure wave in the second channel (12, 13).

Abstract: Methods and devices for attaching biomolecules to a solid substrate surface for example to the inner surface of a capillary. In particular, the invention relates to compounds and methods for creating patterned arrays of biomolecules inside fused silica capillaries so that a plurality of bioassays can be conducted simultaneously.

Abstract: The invention concerns a method to analyse the liquid in a drop (2), comprising: contacting a drop of this liquid with a hydrophobic surface (8), displacing the drop on this surface by electrowetting, to bring it to a site (24, 26, 28) to measure electrical activity in which a conductive solution (42) is arranged, measuring said electrical activity.

Abstract: The invention relates to a method and device for the analysis of reaction media comprising one or more cells, which can be used to perform an automated high-throughput analysis.

Abstract: A device for measuring electrical activity of biological elements, including a substrate that has lower and upper faces and at least one through opening, the opening being delimited by a set of walls. Two plates are placed on either side of the lower and upper faces of the substrate and delimit, with the set of walls, a chamber. Each of the plates is provided, on its face lying opposite the substrate, with at least one electrode facing the opening in the substrate. Each of the plates further has at least one channel that starts inside the chamber and connects the chamber to the outside of the device, and the chamber communicates with the outside of the device only through the channels.

Abstract: The present invention relates to an apparatus for preparing polynucleotides on a solid support in a reactor comprising a column containing an immobilized solid support that is functionalized for polynucleotide synthesis. The solid support can be porous, and can be functionalized with a nucleoside or with a universal synthesis of polynucleotides.

Abstract: The present invention relates to a method and apparatus for performing a large number of reactions using array assembly. In particular, the present invention features a method and apparatus for performing a large number of chemical and biological reactions by bringing two arrays into close apposition and allowing reactants on the surfaces of two arrays to come into contact. The present invention is exemplified by performing a large number of polynucleotide amplification reactions using array assembly. In addition, the present invention features a method and apparatus for coupling the amplification of polynucleotides and the detection of sequence variations, expression levels, and functions thereof.

Abstract: The present invention relates to a method and apparatus for performing a large number of reactions using array assembly. In particular, the present invention features a method and apparatus for performing a large number of chemical and biological reactions by bringing two arrays into close apposition and allowing reactants on the surfaces of two arrays to come into contact. The present invention is exemplified by performing a large number of polynucleotide amplification reactions using array assembly. In addition, the present invention features a method and apparatus for coupling the amplification of polynucleotides and the detection of sequence variations, expression levels, and functions thereof.

Abstract: The present invention relates to an apparatus for preparing polynucleotides on a solid support in a reactor comprising a column containing an immobilized solid support that is functionalized for polynucleotide synthesis. The solid support can be porous, and can be functionalized with a nucleoside or with a universal synthesis of polynucleotides.

Abstract: The present invention relates to an apparatus for preparing polynucleotides on a solid support in a reactor comprising a column containing an immobilized solid support that is functionalized for polynucleotide synthesis. The solid support can be porous, and can be functionalized with a nucleoside or with a universal synthesis of polynucleotides.

Abstract: The invention relates to a microfluidic device for nucleic acid and/or protein analysis, wherein said device comprises a capillary on the inner surface of which is attached an array of at least two reagents. Also encompassed by the invention is such a capillary. In addition, the invention concerns methods for attaching at least two reagents on the inner surface of a capillary, as well as methods using a microfluidic device and enabling a multiplex analysis of nucleic acids and/or proteins to be performed.

Abstract: The present invention relates to an apparatus for preparing polynucleotides on a solid support in a reactor comprising a column containing an immobilized solid support that is functionalized for polynucleotide synthesis. The solid support can be porous, and can be functionalized with a nucleoside or with a universal synthesis of polynucleotides.