Patents by Inventor François Lefoulon

François Lefoulon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the enzymatic synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid or esters thereof, and application in the synthesis of ivabradine and salts thereof
    Patent number: 9506095
    Abstract: Process for the enzymatic synthesis of the compound of formula (I): wherein R1 represents a hydrogen atom or an alkyl group. Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: November 29, 2016
    Assignee: LES LABORATORIES SERVIER
    Inventors: Sandrine Pedragosa-Moreau, François Lefoulon
  • Process for the enzymatic synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carboxylic acid and application in the synthesis of ivabradine and salts thereof
    Patent number: 9476071
    Abstract: Process for the enzymatic synthesis of the compound of formula (I): comprising enantioselective enzymatic hydrolysis of the nitrile of formula (IV): using the nitrilase of Rhodococcus rhodochrous of EMBL accession number EF467367.1, and the application of such a process in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: October 25, 2016
    Assignee: LES LABORATOIRES SERVIER
    Inventors: Sandrine Pedragosa-Moreau, François Lefoulon
  • Imaging agents, process for the preparation thereof and pharmaceutical compositions containing same
    Patent number: 9278143
    Abstract: Compounds of formula (I) in which: >R is a linear or branched (C1-C6) alkyl, >L is a spacer group, >A is a diagnostic agent, and >m is equal to 1 or 2.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: March 8, 2016
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Alain Lepape, Stéphanie Lerondel, Guillaume Reveillon, Jean-Marie Delbos, Luc Demuynck, Hubert Grandon, François Lefoulon, Gordon Tucker
  • Process for the enzymatic synthesis of (7S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl) N-methyl methanamine, and application in the synthesis of ivabradine and salts thereof
    Patent number: 9045788
    Abstract: Process for the enzymatic synthesis of the compound of formula (I), (7S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)N-methyl methanamine: and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: June 2, 2015
    Assignee: LES LABORATOIRES SERVIER
    Inventors: Sandrine Pedragosa-Moreau, François Lefoulon, Francisco Moris Varas, Javier Gonzalez Sabin
  • PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIENE-7-CARBOXYLIC ACID AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF
    Publication number: 20140242644
    Abstract: Process for the enzymatic synthesis of the compound of formula (I): Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Application
    Filed: February 26, 2014
    Publication date: August 28, 2014
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Sandrine Pedragosa-Moreau, François Lefoulon
  • NOVEL IMAGING AGENTS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
    Publication number: 20140241989
    Abstract: Compounds of formula (I) in which: >R is a linear or branched (C1-C6) alkyl, >L is a spacer group, >A is a diagnostic agent, and >m is equal to 1 or 2.
    Type: Application
    Filed: July 12, 2012
    Publication date: August 28, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), LES LABORATOIRES SERVIER
    Inventors: Alain Lepape, Stéphanie Lerondel, Guillaume Reveillon, Jean-Marie Delbos, Luc Demuynck, Hubert Grandon, François Lefoulon, Gordon Tucker
  • Polymerized micelles
    Patent number: 8663660
    Abstract: Polymerized micelles comprising polymerized amphiphilic molecules obtained starting from amphiphilic molecules having one or two lipid chains each comprising one or two polymerizable moieties and linked to a polar head.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: March 4, 2014
    Assignees: Les Laboratories Servier, Commissariat a l'Energie Atomique
    Inventors: Julien Ogier, Eric Doris, François Lefoulon, Thomas Arnauld
  • PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-1-(3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL) N-METHYL METHANAMINE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF
    Publication number: 20140024088
    Abstract: Process for the enzymatic synthesis of the compound of formula (I), (7S)-1-(3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)N-methyl methanamine: and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Application
    Filed: July 15, 2013
    Publication date: January 23, 2014
    Inventors: Sandrine PEDRAGOSA-MOREAU, François LEFOULON, Francisco MORIS VARAS, Javier GONZALEZ SABIN
  • Diosmetin compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 8404742
    Abstract: Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): Medicinal products containing the same which are useful in the prevention and/or treatment of venous diseases and other conditions.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: March 26, 2013
    Assignee: Les Laboratories Server
    Inventors: Michel Wierzbicki, Marie-Francoise Boussard, Tony Verbeuren, Patricia Sansilvestri-Morel, Alain Rupin, Jérôme Paysant, François Lefoulon
  • DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20120208777
    Abstract: Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): Medicinal products containing the same which are useful in the prevention and/or treatment of venous diseases and other conditions.
    Type: Application
    Filed: February 14, 2012
    Publication date: August 16, 2012
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Michel WIERZBICKI, Marie-Françoise BOUSSARD, Tony VERBEUREN, Patricia SANSILVESTRI-MOREL, Alain RUPIN, Jérôme PAYSANT, François LEFOULON
  • Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them
    Patent number: 8138223
    Abstract: Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): Medicinal products containing the same which are useful in the prevention and/or treatment of venous diseases and other conditions.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: March 20, 2012
    Assignee: Les Laboratoires Servier
    Inventors: Michel Wierzbicki, Marie-Françoise Boussard, Tony Verbeuren, Patricia Sansilvestri-Morel, Alain Rupin, Jérôme Paysant, François Lefoulon
  • Strontium salts of sulphonic acids, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 7999009
    Abstract: Strontium salts of the sulphonic acids of formula (I): A-B—SO3H??(I), wherein: A represents a group selected from OH, NH2, SO3H and CO2H, B represents an arylene group or an optionally substituted linear or branched C1-C12alkylene chain wherein one or more carbon atoms of the alkylene chain may be optionally replaced by an oxygen atom, by a nitrogen atom or by an SO2 group. Medicinal products containing the same which are useful in the treatment of osteoarthritis and osteoporosis.
    Type: Grant
    Filed: April 9, 2007
    Date of Patent: August 16, 2011
    Assignee: Les Laboratoires Servier
    Inventors: Francois Lefoulon, Yves Rolland
  • POLYMERIZED MICELLES
    Publication number: 20110105516
    Abstract: Polymerised micelles comprising polymerised amphiphilic molecules obtained starting from amphiphilic molecules having one or two lipid chains each comprising one or two polymerisable moieties and linked to a polar head.
    Type: Application
    Filed: April 28, 2009
    Publication date: May 5, 2011
    Applicants: LES LABORATOIRES SERVIER, COMMISSARIAT A L'ENERGIE ATOMIQUE
    Inventors: Julien Ogier, Eric Doris, Francois Lefoulon, Thomas Arnauld
  • Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them
    Publication number: 20090247621
    Abstract: Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): Medicinal products containing the same which are useful in the prevention and/or treatment of venous diseases and other conditions.
    Type: Application
    Filed: March 30, 2009
    Publication date: October 1, 2009
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Michel Wierzbicki, Marie-Francoise Boussard, Tony Verbeuren, Patricia Sansilvestri-Morel, Alain Rupin, Jerome Paysant, Francois Lefoulon
  • Strontium salts of sulphonic acids, a process for their preparation and pharmaceutical compositions containing them
    Publication number: 20070244191
    Abstract: Strontium salts of the sulphonic acids of formula (I): A-B—SO3H , ??(I) wherein: A represents a group selected from OH, NH2, SO3H and CO2H, B represents an arylene group or an optionally substituted linear or branched C1-C12alkylene chain wherein one or more carbon atoms of the alkylene chain may be optionally replaced by an oxygen atom, by a nitrogen atom or by an SO2 group. Medicinal products containing the same which are useful in the treatment of osteoarthritis and osteoporosis.
    Type: Application
    Filed: April 9, 2007
    Publication date: October 18, 2007
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Francois Lefoulon, Yves Rolland
  • Salt of perindopril and pharmaceutical compositions containing it
    Patent number: 6696481
    Abstract: The present invention relates to a new salt of perindopril and to pharmaceutical compositions containing it, and Medicaments for treatment of hypertension and heart failure.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: February 24, 2004
    Assignee: Les Laboratoires Servier
    Inventors: Gérard Damien, François Lefoulon, Bernard {acute over (M)}archand
  • SALT OF PERINDOPRIL AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
    Publication number: 20030199568
    Abstract: The present invention relates to a new salt of perindopril and to pharmaceutical compositions containing it.
    Type: Application
    Filed: February 21, 2003
    Publication date: October 23, 2003
    Inventors: Gerard Damien, Francois Lefoulon, Bernard Marchand
  • Substituted dimeric compounds
    Patent number: 6635650
    Abstract: The invention relates to compounds of formula (I): A-G1-Cy-G2-Cy-G3-B  (I) wherein: A represents NR1C(Q)R2, C(Q)NR2R3 or NR1C(Q)NR2R3, B represents NR1C(Q)R2, C(Q)NR2R3, NR1C(Q)NR2R3, C(Q)OR1, NR1C(Q)OR2 or NR2R3, G1 and G3 represent an optionally substituted alkylene chain, Cy represents a ring structure G2 represents a chain and medicinal products containing the same which are useful in treating or in preventing melatoninergic disorders.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: October 21, 2003
    Assignee: Les Laboratoires Servier
    Inventors: Daniel Lesieur, Said Yous, Carole Descamps-Francois, François Lefoulon, Gérald Guillaumet, Marie-Claude Viaud, Caroline Bennejean, Philippe Delagrange, Pierre Renard
  • Benzothiadiazine compounds
    Patent number: 6635635
    Abstract: Compound of formula (I): wherein: R1 represents hydroxy, RCO—O— or RCO—NRa—, R2 represents hydrogen, halogen, or hydroxy, R′CO—O or R′CO—NR′a—, R and R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, Ra and R′a, which may be identical or different, represent hydrogen or linear or branched (C1-C6)alkyl, linear or branched (C1-C6)perhaloalkyl, linear or branched (C1-C6)acyl, aryl or heteroaryl, its isomer and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as AMPA modulators.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: October 21, 2003
    Assignee: Les Laboratoires Servier
    Inventors: Alex Cordi, Patrice Desos, François Lefoulon, Pierre Lestage
  • Benzothiadiazine compounds
    Publication number: 20020037894
    Abstract: Compound of formula (I): 1
    Type: Application
    Filed: July 27, 2001
    Publication date: March 28, 2002
    Inventors: Alex Cordi, Patrice Desos, Francois Lefoulon, Pierre Lestage