Abstract: The present invention is concerned with novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives of Formula (I) wherein R1, R2, R3, R4, X, A1, A2, A3, A4, Y1, Y2, Y3 and Z have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het1, Het2, A1, A2, A3 and A4 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The invention relates to the use of a compound comprising D-mannoheptulose and/or perseitol for producing a drug for treating and/or preventing diseases related to the modification of an innate and/or acquired immunity by increasing the production of antimicrobial peptides, preferably hBD-2 without inducing inflammatory reactions, irritation or intolerance. Said compound can also comprise a peptidic avocado extract an/or a peptidic lupin extract.

Abstract: The present invention is concerned with novel substituted bicyclic imidazole derivatives of Formula (I) wherein R0, R1, R3, R4, X, A1, A2, A3, A4, Y1, Y2 and Y3 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said novel compound as an active ingredient as well as the use of said compounds as a medicament.

Abstract: A method for communicating media program information is provided. The method includes receiving a content-augmented broadcast signal at a conventional broadcast receiver, the content-augmented broadcast signal having a program content and a program cookie relating to the program content, demodulating the content-augmented broadcast signal, rendering the program content, recovering the program cookie from the demodulated content-augmented broadcast signal at substantially the same time the program content is rendered, determining whether the program cookie comprises information relating to a current media program a user is currently watching or listening to, or to an advertisement of a future media program, and sending the program cookie to an electronic device.

Abstract: A window regulator device includes a rail having at least one projecting lug, a plate having at least one lug, a drive cable, and a cable drum placed in a recess of the plate. The plate is fixed to the rail by a joint action of a tensioned drive cable and the mutual imbrication of the lugs of the plate and the rail. The assembly of the window regulator device is simplified, and the drum can be fixed independently of the mounting and removal of an actuation motor.

Abstract: The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose and/or perseitol, such as a water-soluble extract of avocado sugars, and/or a peptide extract of lupine. The inventive medicament is intended for the treatment and/or prevention of illnesses that are linked to an alteration in innate and/or acquired immunity, through an increase in the production of anti-microbial peptides, preferably hBD-2, without inducing inflammatory reactions, irritations or intolerances.

Abstract: The invention relates to the use of a compound comprising D-mannoheptulose and/or perseitol for producing a drug for treating and/or preventing diseases related to the modification of an innate and/or acquired immunity by increasing the production of antimicrobial peptides, preferably hBD-2 without inducing inflammatory reactions, irritation or intolerance. Said compound can also comprise a peptidic avocado extract and/or a peptidic lupin extract.

Abstract: The escapement racks for the hour (11), for the quarter-hour (10) and for the minutes (9) on the minute-repeater are mounted such that the same pivot about a common axis (14), with the escapement racks for the hour and the quarter-hour on one side, and the racks for the quarter-hour and for the minutes on the other side connected by a unidirectional drive connection having a ratchet (15, 17), a toothed pawl (10a, 9a) engaging with the ratchet, a banking pin (10b, 9b) and a cam (16b, 18b) to enable selective engagement of the ratchet with the pawl teeth. The end of the motor spring is kinetically secured to the two separate sets of activating pawl teeth (13a, 13b) for the first chime lift (21), with the first set of teeth (13a) for the hour chime, and the second set of teeth (13b) for chiming quarter-hours and minutes.

Abstract: The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose and/or perseitol, such as a water-soluble extract of avocado sugars, and/or a peptide extract of lupine. The inventive medicament is intended for the treatment and/or prevention of illnesses that are linked to an alteration in innate and/or acquired immunity, through an increase in the production of anti-microbial peptides, preferably hBD-2, without inducing inflammatory reactions, irritations or intolerances.

Abstract: A disc drive (1) comprises first clamping means (5) and second clamping means (7) for supporting an optical disc (3) that is to be played in the disc drive (1). Drive means (9) is provided for rotating the optical disc (3) relative to optical means (11) for writing data to, or reading data from, the optical disc (3). The disc drive (1) further comprises a data storage medium (13) for storing data such as embedded software for controlling the operation of the disc drive (1). The data storage medium (13) is permanently located in the disc drive (1), thereby being permanently available for controlling the operation of the disc drive (1). The data storage medium (13) is located coaxially with optical disc (3) that is to be inserted into the disc drive (1) for playback. The data storage medium (13) is also positioned such that, during playback of a normal optical disc (3), the data storage medium is located on the reverse side of the optical disc (13), i.e. the non-optical side of the optical disc (3).

Abstract: The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose an/or perseitol, such as a water-soluble extract of avocado sugars, and/or a peptide extract of lupine. The inventive medicament is intended for the treatment and/or prevention of illnesses that are linked to an alteration in innate and/or acquired immunity, through an increase in the production of anti-microbial peptides, preferably hBD-2, without inducing inflammatory reactions, irritations or intolerances.

Abstract: A composition comprising a hydrolyzed peptide extract of a lupin and a method of producing the same.

Abstract: A sliding door carriage for a vehicle includes a first point for fixing a first cable strand for driving in a first direction, and a second point for fixing a second cable strand for driving in a second direction. Each fixing point is offset toward a rear of the sliding door carriage relative to a direction of driving by the respective cable strand. The sliding door carriage can be included in a sliding door driving system, and the sliding door driving system can be included in a vehicle. The bulk of the sliding door driving system in a body of a vehicle can be reduced.

Abstract: This pushbutton device for controlling the start/stop and resetting functions of a chronograph mechanism comprises two control pushbuttons able to slide between two limit positions, elastic return means which constantly tend to keep these pushbuttons in their outward limit positions, and a control rocker which pivots about a pivot. The control rocker is situated between the pushbuttons, the latter being, in their outward limit positions, simultaneously in contact with the control rocker, keeping it in a middle position between the limit positions of its pivoting, which correspond to the movement of the pushbuttons to their respective inward limit positions.

Abstract: A method for the routing of information in a network comprises several communication nodes that may be mobile, the routing being done by a route between a source node and a destination node through a set of wireless communication links between the nodes of the network, the entire set forming a graph wherein the method comprises at least one step in which the graph of the network is structured as a unicast two-way link in order to obtain the relationships existing between two nodes and form, during routing decisions, sub-graphs comprising arcs that connect two nodes, the arcs sharing one and the same set of properties.

Abstract: Writing implement (1) of longitudinal axis (2), comprising an essentially tubular body (30), a retractable nib (10), an actuator (35) and a retractor (40) for retracting said nib (10). It also comprises a guard member (20) comprising a plurality of guard petals (21), each mounted so as to be able to move between an open position and a closed position about a pivot axis (22), and a movement transfer mechanism (31). This last is integral with said body (30), is synchronized by said retractor (40), and is connected to said guard petals (21) to transfer the movement applied to the actuator (35) into a pivoting movement of said guard petals.

Abstract: The present invention is concerned with radiolabelled quinoline and quinolinone derivatives according Formula (I-A)* or (I-B)* showing metabotropic glutamate receptor antagonistic activity, in particular mGlu1 receptor activity, and their preparation; it further relates to compositions comprising them, as well as their use for marking and identifying metabotropic glutamate receptor sites and for imaging an organ.

Abstract: This adjustment device comprises: a first adjustment member with a fixed position relative to the longitudinal axis of the strap; first guide means connected to this first adjust member; a connecting member engaged on the one hand with said first guide means and on the other hand with the other of the strap halves; second guide means for rotational guidance, connected to said first adjustment member; a second or manual adjustment member having guide means shaped to engage with said second guide means of the first adjustment member; and means for transmitting movement between said second or manual adjustment member and said connecting member to turn the circular movement of the second or manual adjustment member into a rectilinear movement of said connecting member.

Abstract: This pushbutton device for controlling the start/stop and resetting functions of a chronograph mechanism comprises two control pushbuttons able to slide between two limit positions, elastic return means which constantly tend to keep these pushbuttons in their outward limit positions, and a control rocker which pivots about a pivot. The control rocker is situated between the pushbuttons, the latter being, in their outward limit positions, simultaneously in contact with the control rocker, keeping it in a middle position between the limit positions of its pivoting, which correspond to the movement of the pushbuttons to their respective inward limit positions.