Patents by Inventor Frances P. Gillispie

Frances P. Gillispie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid encoding a chimeric polypeptide
    Patent number: 7122354
    Abstract: DNA molecules comprising a sequence encoding the signal peptide of hGH linked to a heterologous protein and related cells, methods and fusion proteins.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: October 17, 2006
    Assignee: Transkaryotic Therapies, Inc.
    Inventors: Richard F. Selden, Marianne Borowski, Frances P. Gillispie, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams
  • Nucleic acid encoding a chimeric polypeptide
    Publication number: 20030152560
    Abstract: A therepeutic method whereby an individual suspected of having an &agr;-galactosidase A deficiency, such as Fabry disease, is treated either with (1) human cells that have been genetically modified to overexpress and secrete human &agr;-gal A, or (2) purified human &agr;-gal A obtained from cultured, genetically modified human cells.
    Type: Application
    Filed: December 12, 2002
    Publication date: August 14, 2003
    Applicant: Transkaryotic Therapies Inc., a Massachusetts corporation
    Inventors: Richard F. Selden, Marianne Borowski, Frances P. Gillispie, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams
  • Nucleic acid encoding a chimeric polypeptide
    Patent number: 6566099
    Abstract: A therapeutic method whereby an individual suspected of having an &agr;-galactosidase A deficiency, such as Fabry disease, is treated either with (1) human cells that have been genetically modified to overexpress and secrete human &agr;-gal A, or (2) purified human &agr;-gal A obtained from cultured, genetically modified human cells.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: May 20, 2003
    Assignee: Transkaryotic Therapies, Inc.
    Inventors: Richard F. Selden, Marianne Borowski, Frances P. Gillispie, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams
  • Therapy for &agr;-galactosidase a deficiency
    Patent number: 6395884
    Abstract: A therepeutic method whereby an individual suspected of having an &agr;-galactosidase A deficiency, such as Fabry disease, is treated either with (1) human cells that have been genetically modified to overexpress and secrete human &agr;-gal A, or (2) purified human &agr;-gal A obtained from cultured, genetically modified human cells.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: May 28, 2002
    Assignee: Transkaryotic Therapies, Inc.
    Inventors: Richard F. Selden, Marianne Borowski, Frances P. Gillispie, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams
  • Tranfected human cells expressing human .alpha.-galactosidase A protein
    Patent number: 6083725
    Abstract: A therepeutic method whereby an individual suspected of having an .alpha.-galactosidase A deficiency, such as Fabry disease, is treated either with (1) human cells that have been genetically modified to overexpress and secrete human .alpha.-gal A, or (2) purified human .alpha.-gal A obtained from cultured, genetically modified human cells.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: July 4, 2000
    Assignee: Transkaryotic Therapies, Inc.
    Inventors: Richard F. Selden, Marianne Borowski, Frances P. Gillispie, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams