Abstract: The present invention is directed to novel pharmaceutically acceptable, addition salts of (S)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile with sulfonic acid derivatives, in particular with methanesulfonic acid, naphthalene-2-sulfonic acid and para-toluenesulfonic acid, and pharmaceutically acceptable solvates thereof, and their use as Phosphoinositide 3-Kinase (PI3K) inhibitors.

Abstract: The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a dicarboxylic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.

Abstract: The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a hydroxycarboxylic acid, a sulfonic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.

Abstract: The present invention is directed to crystalline addition salts of (ii) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a dicarboxylic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.

Abstract: The present invention is directed to novel polymorphic crystal forms of a 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisylate. The invention is also directed to pharmaceutical compositions comprising said polymorphic crystal forms, methods of using them to treat respiratory diseases associated with ?2 adrenergic receptor activity and a process for preparing such polymorphic crystal forms.

Abstract: The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a hydroxycarboxylic acid, a sulfonic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.

Abstract: The present invention is directed to a pharmaceutically acceptable crystalline addition salt of 5-[(1R)-2-({2-[4-({4-(2,2-difluoro-2-phenylethoxy)phenyl]ethyl}amino)-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one, and (ii) a dicarboxylic acid, a sulfonic acid or a sulfimide, or a pharmaceutically acceptable solvate thereof.

Abstract: The present invention is directed to novel polymorphic crystal forms of a 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisylate. The invention is also directed to pharmaceutical compositions comprising said polymorphic crystal forms, methods of using them to treat respiratory diseases associated with ?2 adrenergic receptor activity and a process for preparing such polymorphic crystal forms.

Abstract: The present disclosure relates to a mesylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the ?2 receptor.

Abstract: The present disclosure is directed to the sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid, pharmaceutically acceptable solvates thereof, pharmaceutical combinations thereof, and methods of treatment.

Abstract: The present disclosure is directed to novel water-soluble pharmaceutically acceptable, crystalline addition salts of (i) an amine containing one or more hydroxyl and/or carboxylic groups with (ii) amino nicotinic acid derivatives of formula (I) pharmaceutically acceptable solvates thereof, pharmaceutical combinations thereof, and methods of treatment.

Abstract: The present disclosure is directed to novel crystalline addition salts of (i) tromethamine with (ii) an azabiphenylaminobenzoic acid derivatives of formula (I), pharmaceutically acceptable solvates thereof, pharmaceutical combinations thereof, and methods of treatment.

Abstract: The present disclosure is directed to the sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid, pharmaceutically acceptable solvates thereof, pharmaceutical combinations thereof, and methods of treatment.

Abstract: The present disclosure relates to a mesylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the ?2 receptor.

Abstract: Steam iron having a sole plate with a steam chamber, and a sealed liquid reservoir. A drip valve supplies the steam chamber with liquid from the liquid reservoir. One or more one-way gas valves between the liquid reservoir and ambient air let air enter the reservoir in response to local negative pressures within the reservoir caused by movement of water within the reservoir, such as during reciprocal ironing motion. A pressure-equalizing passage is formed within a manually operable rod of the drip valve, such that only one opening is required in the lower wall of the liquid reservoir.

Abstract: Steam iron having a sole plate with a steam chamber, and a sealed liquid reservoir. A drip valve supplies the steam chamber with liquid from the liquid reservoir. One or more one-way gas valves between the liquid reservoir and ambient air let air enter the reservoir in response to local negative pressures within the reservoir caused by movement of water within the reservoir, such as during reciprocal ironing motion. A pressure-equalizing passage is formed within a manually operable rod of the drip valve, such that only one opening is required in the lower wall of the liquid reservoir.

Abstract: The invention is directed to a processing device for stirring or reducing foods, particularly a handheld blender, with a motor driven tool shaft extending in a housing part of the housing of the processing device and having a work performing element secured to the shaft's output end. The housing part becomes a protective shield in the area of the output end of the tool shaft, said shield encompassing the work performing element in a radial direction at least in part and terminating in an opening edge at its lower open end. To ensure that the processing tool is not only adequately protected in an initial position by the shield but also well suited to reduce large pieces of solid foods, means are provided for enabling a relative axial displacement of the work performing element and the opening edge of the shield.

Abstract: The art knows of a processing tool for mixing or comminuting food materials, with a working shaft (4) which is carried in a shaft housing (2) in the area of its input end and is adapted to be coupled to a drive motor of a kitchen appliance. In the area of its output end, the shaft (4) is centrally carried in a bearing sleeve (7) and fixed in an axial direction and has fastened to its output end a work performing element (6), said shaft housing (2) merging in the area of the output end of the shaft (4) into a flared bell-shaped housing (3) whose inner space is separated from the inner space of the shaft housing (2) by a cover plate (18) through which the shaft output end extends outwardly by passing through a bore (24). The bearing sleeve (7) is inserted and held in an axial direction in a supporting member (8) which bears against the cover plate (18) on the side pointing towards the interior of the shaft housing (2) and overlaps axially with an extension (17) of the cover plate (18).

Abstract: The invention is directed to a smoothing iron having a shoe and a soleplate, in which the shoe and the soleplate are joined to each other by an adhesive. The spacing between the shoe and the soleplate varies across the shoe. The space between the shoe and the soleplate is filled with the adhesive. No prior mechanical treatment or heating of the shoe and/or the soleplate is required.

Abstract: The invention is directed to a smoothing iron having an approximately triangular metal soleplate including a sliding surface 4 and an edge area 6 encircling the sliding surface and overlapping it partially. The edge area 6 is bent in an upward and inward direction at an angle of 35.degree., maximum, relative to the sliding surface 4. At the tips of the triangle, the edge area includes a slot 8 formed by the side edges of a notch cut in the blanked metal soleplate. The edge area is angled by a forming operation involving several steps.