Abstract: In a method and a cartridge for carrying out a reaction between a sample fluid and at least one reagent, in particular for carrying out LAMP assays, the cartridge includes at least one channel pair including a sample channel into which a sample fluid can be introduced and a reagent channel into which a reagent fluid can be introduced, the sample channel and the reagent channel being disposed so as to intersect one another whereby sample fluid can be transferred from an intersecting region into the reagent channel.

Abstract: This invention relates to an in vitro system for the culture of cerebellar granule cell precursors (granule cell progenitors, GCP) comprising a culture support, mammalian GCP cells and a culture medium comprising at least SAG (Smoothened agonist) and EGF (Epidermal Growth Factor), and a method for the in vitro culture of GCP cells, use of the above-mentioned culture system or method of culture for the generation of in vitro models for study of the pathophysiology of cerebellar granules or use of the above-mentioned culture system or method of culture for use in gene therapy and cell therapy approaches to cerebellar diseases caused by damage or neurodegeneration.