Patents by Inventor Francesco Fontana

Francesco Fontana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Machine for the production of ceramic products
    Patent number: 9925689
    Abstract: A machine (1) for the production of ceramic products includes: a mould (2) made up of two parts (3, 4) designed to define, in a closed configuration, a cavity for casting the product; an apparatus (5) for clamping and containing the mould (2) acting on the mould (2) in its closed configuration; a frame (7) for supporting the mould (2) and clamping and containing apparatus (5).
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: March 27, 2018
    Assignee: SACMI COOPERATIVA MECCANICI IMOLA SOCIETA' COOPERATIVA
    Inventors: Francesco Fontana, Giorgio Sarani
  • Process for the preparation of Efavirenz using keton solvents
    Patent number: 9670169
    Abstract: An improved process for the preparation of Efavirenz which avoids the distillations of the solvents is provided.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: June 6, 2017
    Assignee: F.I.S.—FABRICA ITALIANA SINTETICI S.P.A.
    Inventors: Francesco Fontana, Pierluigi Padovan, Marco Prebianca
  • MACHINE FOR THE PRODUCTION OF CERAMIC PRODUCTS
    Publication number: 20170113375
    Abstract: A machine (1) for the production of ceramic products comprises: a mould (2) made up of two parts (3, 4) designed to define, in a closed configuration, a cavity for casting the product; means (5) for clamping and containing the mould (2) acting on the mould (2) in its closed configuration; a frame (7) for supporting the mould (2) and clamping and containing means (5).
    Type: Application
    Filed: March 26, 2015
    Publication date: April 27, 2017
    Inventors: Francesco FONTANA, Giorgio SARANI
  • Methods for detecting and reducing impurities of Lapatinib and salts thereof
    Patent number: 9606089
    Abstract: Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound of formula (I) or a salt thereof: and analytical methods for identifying and quantifying such impurities of Lapatinib and salts thereof are provided. Also provided is Lapatinib containing less than about 0.05 percent of this and related impurities and methods for preparing such pure forms of Lapatinib.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: March 28, 2017
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Francesco Fontana, Alessandro Leganza, Sergio Osti
  • PROCESS FOR THE PREPARATION OF EFAVIRENZ USING KETON SOLVENTS
    Publication number: 20170008861
    Abstract: An improved process for the preparation of Efavirenz which avoids the distillations of the solvents is provided.
    Type: Application
    Filed: May 7, 2015
    Publication date: January 12, 2017
    Inventors: Francesco FONTANA, Pierluigi PADOVAN, Marco PREBIANCA
  • Efficient process for the preparation of Lapatinib and salts thereof by means of new intermediates
    Patent number: 9359333
    Abstract: The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: June 7, 2016
    Assignee: F.I.S.—Fabbrica Italiana Sintetiei
    Inventors: Francesco Fontana, Alfredo Paio
  • Efficient Process for the Preparation of Lapatinib and Salts Thereof by Means of New Intermediates
    Publication number: 20150322050
    Abstract: The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.
    Type: Application
    Filed: July 21, 2015
    Publication date: November 12, 2015
    Applicant: F.I.S. - Fabbrica Italiana Sintetici S.p.A.
    Inventors: Francesco FONTANA, Alfredo PAIO
  • Efficient process for the preparation of lapatinib and salts thereof by means of new intermediates
    Patent number: 9169236
    Abstract: The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: October 27, 2015
    Assignee: F.I.S.-Fabbrica Italiana Sintetiei S.p.A.
    Inventors: Francesco Fontana, Alfredo Paio
  • METHODS FOR DETECTING AND REDUCING IMPURITIES OF LAPATINIB AND SALTS THEREOF
    Publication number: 20150260696
    Abstract: Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound of formula (I) or a salt thereof: and analytical methods for identifying and quantifying such impurities of Lapatinib and salts thereof are provided. Also provided is Lapatinib containing less than about 0.05 percent of this and related impurities and methods for preparing such pure forms of Lapatinib.
    Type: Application
    Filed: September 10, 2014
    Publication date: September 17, 2015
    Inventors: Francesco FONTANA, Alessandro Leganza, Sergio Osti
  • Efficient Process for the Preparation of Lapatinib and Salts thereof by Means of New Intermediates
    Publication number: 20150225376
    Abstract: The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.
    Type: Application
    Filed: February 18, 2015
    Publication date: August 13, 2015
    Applicant: F.I.S. - Fabbrica Italiana Sintetici S.p.A.
    Inventors: Francesco FONTANA, Alfredo Paio
  • Efficient process for the preparation of lapatinib and salts thereof by means of new intermediates
    Patent number: 9024023
    Abstract: The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: May 5, 2015
    Assignee: F.I.S.—Fabbrica Italiana Sintetici S.p.A.
    Inventors: Francesco Fontana, Alfredo Paio
  • Process for the preparation of 2-cyanophenylboronic acid and esters thereof
    Patent number: 9000205
    Abstract: The present invention relates to a process for the synthesis of 2-cyanophenylboronic acid and the esters and salts thereof of formula (II), which are intermediates of the synthesis of active pharmaceutical ingredients such as Perampanel or E2040. formula (II): (II).
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: April 7, 2015
    Assignee: F.I.S.—Fabbrica Italiana Sintetici S.p.A.
    Inventors: Francesco Fontana, Emiliano Rossi, Christian De Filippo
  • EFFICIENT PROCESS FOR THE PREPARATION OF LAPATINIB AND SALTS THEREOF BY MEANS OF NEW INTERMEDIATES
    Publication number: 20150065710
    Abstract: The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.
    Type: Application
    Filed: September 3, 2013
    Publication date: March 5, 2015
    Applicant: F.I.S. - Fabbrica Italiana Sintetici S.p.A.
    Inventors: Francesco Fontana, Alfredo Paio
  • Methods for detecting and reducing impurities of Lapatinib and salts thereof
    Patent number: 8927558
    Abstract: Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound of formula (I) or a salt thereof: and analytical methods for identifying and quantifying such impurities of Lapatinib and salts thereof are provided. Also provided is Lapatinib containing less than about 0.05 percent of this and related impurities and methods for preparing such pure forms of Lapatinib.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: January 6, 2015
    Assignee: F.I.S.—Fabbrica Italiana Sintetici S.p.A.
    Inventors: Francesco Fontana, Alessandro Leganza, Sergio Osti
  • PROCESS FOR THE PREPARATION OF 2-CYANOPHENYLBORONIC ACID AND ESTERS THEREOF
    Publication number: 20140357886
    Abstract: The present invention relates to a process for the synthesis of 2-cyanophenylboronic acid and the esters and salts thereof of formula (II), which are intermediates of the synthesis of active pharmaceutical ingredients such as Perampanel or E2040. formula (II): (II).
    Type: Application
    Filed: July 24, 2013
    Publication date: December 4, 2014
    Inventors: Francesco Fontana, Emiliano Rossi, Christian De Filippo
  • Methods for the preparation of lapatinib and the salts thereof
    Patent number: 8853396
    Abstract: Methods for the synthesis of the pharmaceutically active ingredient Lapatinib and the salts thereof are provided. In particular, such methods utilize intermediates in which the hydroxyl function is protected by a tetrahydropyranyl group providing greater solubility of the intermediates in common organic solvents.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: October 7, 2014
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventor: Francesco Fontana
  • Methods for preparing intermediates of perampanel
    Patent number: 8742118
    Abstract: Methods for the synthesis of 2-alkoxy-5-(pyridin-2-yl)pyridine of formula I or salts thereof are provided.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: June 3, 2014
    Assignee: F.I.S.—Fabbrica Italiana Sintetici S.p.A.
    Inventors: Francesco Fontana, Paolo Stabile
  • Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib
    Patent number: 8664402
    Abstract: A process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methyl sulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. The synthesis of the intermediates useful for such preparation is also described.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: March 4, 2014
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Andrea Castellin, Paolo Stabile, Francesco Fontana, Ottorino De Lucchi, Andrea Caporale, Stefano Tartaggia
  • METHODS FOR DETECTING AND REDUCING IMPURITIES OF LAPATINIB AND SALTS THEREOF
    Publication number: 20120295928
    Abstract: Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound of formula (I) or a salt thereof: and analytical methods for identifying and quantifying such impurities of Lapatinib and salts thereof are provided. Also provided is Lapatinib containing less than about 0.05 percent of this and related impurities and methods for preparing such pure forms of Lapatinib.
    Type: Application
    Filed: May 14, 2012
    Publication date: November 22, 2012
    Applicant: F.I.S. FABBRICA ITALIANA SINTETICI S.p.A.
    Inventors: Francesco Fontana, Alessandro Leganza, Sergio Osti
  • METHODS FOR THE PREPARATION OF LAPATINIB AND THE SALTS THEREOF
    Publication number: 20120245350
    Abstract: Methods for the synthesis of the pharmaceutically active ingredient Lapatinib and the salts thereof are provided. In particular, such methods utilize intermediates in which the hydroxyl function is protected by a tetrahydropyranyl group providing greater solubility of the intermediates in common organic solvents.
    Type: Application
    Filed: March 8, 2012
    Publication date: September 27, 2012
    Applicant: F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.
    Inventor: Francesco Fontana