Abstract: An ophthalmic injection system having coaxial cannulae includes a plurality of syringe bodies and a plurality of cannulae, wherein a first non-flexible cannula is configured to accommodate and guide a second cannula that moves inside the first cannula and penetrates into the internal cavity of an eye globe. The first cannula is long enough to penetrate one or more outer layers of the eye globe. A syringe body is connected to the second cannula for accommodation and infusion of a pharmaceutical composition. A plunger is inserted into an annular space of the second syringe body at its distal end for injecting the pharmaceutical composition to the surgical site.