Abstract: A method and apparatus for spectrophotometry for non-invasively measuring the chemistry of the blood in the eye.

Abstract: The device for benign, non-surgical external shaping of corneal tissue to compensate, by refractive correction, for deviations from normal focussing. The jet is directed to erode corneal tissue to provide an increase in curvature to correct for far-sightedness i.e., to refocus a perceived image from beyond retina onto the surface of the retina.

Abstract: A method and device for benign, non-surgical external shaping of corneal tissue to compensate, by refractive correction, for deviations from normal focussing. Corneal tissue is externally gently removed by erosion to a maximum 30% depth, within several seconds, by an imperceptibly felt, highly controlled and limited area, isotonic water jet, exerting a total force of at most several ounces. The jet is directed to erode corneal tissue to provide an increase in curvature to correct for far-sightedness i.e., to refocus a perceived image from beyond retina onto the surface of the retina. To correct for near-sightedness and to refocus a perceived image from in front of the retina onto the surface of the retina, the jet is directed to flatten out by eroding, a central portion of corneal tissue, to decrease curvature. The jet is either applied by a nozzle or array of nozzles. The jet is applied and directed, in a computer controlled, raster or similar type movement, until the desired diopter change is effected.

Abstract: The invention contemplates a method for making a disposable element adapted for selective placement in the path of laser beam delivery to the cornea. The element carries a membrane of uniform thickness which is opaque to the laser-beam and which is subject to ablation when exposed to the laser beam. The central area of the uniform thickness membrane is then selectively exposed to the laser-beam so as to cause full depth removal at one locality in the central area and essentially zero depth removal at another area, so as to provide an article which, when interposed the cornea and an ablative laser beam, will, during a given laser-beam course of exposure will require greater or lesser time to locally ablate the membrane and thus permit laser-beam exposure past the membrane and into correspondingly localized ablating impingement with the cornea. Stated in other words, the article so manufactured will provide a varying spot size at the cornea on illumination with a laser-beam of uniform intensity profile.

Abstract: The invention contemplates an inventory of disposable elements adapted for selective placement in the path of laser-beam delivery to the cornea. Each of the disposable elements carries a membrane which is opaque to the laser beam and which is designedly subject to ablation when exposed to the laser beam, the thickness of the membrane being a precharacterized function of local area such that a given laser-beam course of exposure will require greater or lesser time to locally ablate the membrane and thus permit laser-beam exposure past the membrane and into correspondingly localized ablating impingement with the cornea. Stated in other words, varying-spot size at the cornea is achieved by a time-release function of the membrane, on a predetermined area-controlled basis that is designed to achieve the diopter change specifically identified with each particular selectable element.

Abstract: The invention contemplates controlled ablation of the cornea, using ultraviolet laser radiation, wherein irradiated flux density and exposure time are so controlled as to achieve desired depth of the ablation. Sculpturing action results from precharacterized distribution of flux density across the cross-section of laser-beam projection, in the context of beam size, at cornea incidence, to match the area to be ablated, and the duration of exposure determines the extent of curvature change. Illustrative techniques and situations are disclosed, for myopia correction, for hyperopia correction, and for astigmatism correction.

Abstract: The invention contemplates a surgically implantable device for controlled drainage flow of aqueous fluid from the anterior chamber of the eye into nearby subconjunctival space, all in relief of a glaucomatous condition of excessive pressure within the eye. The device includes provision for so controlling the rate of aqueous flow as to assure against anterior-chamber collapse, thus avoiding irreparable damage which might otherwise result to the corneal endothelium, to the iris, or to the lens of the eye.

Abstract: A hand-held phaco-extractor instrument comprises an elongate tubular irrigation/aspiration system for a distal or operating end, wherein a fiber-optic cable delivers laser-irradiation of wavelength which is so substantially coincident with the known high absorptivity in water that laser-energy penetration is essentially limited to the region of cataractous-lens tissue to be fragmented and extracted. In other words, for the aqueous environment in which the particular laser radiation is to do its fragmentation, there is no possibility of damaging radiation penetration to the retina or to other regions of the eye which are irrelevant to the involved cataract-removal surgery.

Abstract: An instrument for ophthalmic surgery to remove cataractous-lens tissue has an elongate stem which enables external manipulation at its proximal end and which at its distal end presents a cutter adjacent a transiently open cavity into which cut or chopped tissue can be manipulated. The instrument provides for selectively operated closure of the thus-loaded cavity, an event which must occur before laser radiation can issue within the cavity, in fragmenting or emulsifying reduction of cut or chopped tissue within the cavity. Thus, reduced, the fragmented material is extracted by an aspirating flow of liquid. This process is repeated until the capsulary bag has been cleared of cataractous material, be it nuclear or cortical.

Abstract: The invention contemplates controlled ablation of the cornea, using ultraviolet laser radiation, wherein irradiated flux density and exposure time are so controlled as to achieve desired depth of the ablation. Sculpturing action results from precharacterized distribution of flux density across the cross-section of laser-beam projection, in the context of beam size, at cornea incidence, to match the area to be ablated, and the duration of exposure determines the extent of curvature change. Illustrative techniques and situations are disclosed, for myopia correction, for hyperopia correction, and for astigmatism correction.

Abstract: The invention contemplates controlled ablation of the cornea, using ultraviolet laser radiation, wherein irradiated flux density and exposure time are so controlled as to achieve desired depth of the ablation. Sculpturing action results from precharacterized distribution of flux density across the cross-section of laser-beam projection, in the context of beam size, at cornea incidence, to match the area to be ablated, and the duration of exposure determines the extent of curvature change. Illustrative techniques and situations are disclosed, for myopia correction, for hyperopia correction, and for astigmatism correction.

Abstract: The invention contemplates controlled ablation of the cornea, using ultraviolet laser radiation, wherein irradiated flux density and exposure time are so controlled as to achieve desired depth of the ablation. Sculpturing action results from precharacterized distribution of flux density across the cross-section of laser-beam projection, in the context of beam size, at cornea incidence, to match the area to be ablated, and the duration of exposure determines the extent of curvature change. Illustrative techniques and situations are disclosed, for myopia correction, for hyperopia correction, and for astigmatism correction.

Abstract: The invention contemplates laser-aseptic phototherapy, for enhanced sterilization of an area of prospective surgical invasion of living tissue, by first administering, intravenously, orally or otherwise as appropriate, a photosensitizing agent having the property, in the course of an acceptable period of time, of selective concentrated absorption in bacteria and other microorganisms such as those which exist at depth in hair follicles, and then, following lapse of the time period, applying laser irradiation to the area of prospective surgery, using a wavelength and power density selected for absorptive response by the photosensitive agent, whereby microorganisms are destroyed at and beneath the irradiated area.

Abstract: The invention comtemplates promotion or enhanced promotion of vascular or other growth in living body tissue through effectively concurrent in-vivo delivery of at least two beams of laser irradiation at an affected area of body tissue, wherein the irradiation (a) is of low intensity at tissue impingement and (b) is also of spectral wavelength that is preferably in the visible red or in the infrared. Perturbations result in affected cells either directly by reason of differences in the physical properties of the respective beams or indirectly by reason of interaction between the two beams at or near the situs of delivery to the affected body tissue.

Abstract: In the context of ultraviolet-laser sculpting of the cornea to achieve optical correction through a newly shaped anterior surface, the invention subjects the laser beam to certain shaping and homogenizing operations prior to any attempt to specially characterize the beam for a particular sculpturing procedure. In a preferred embodiment, the shaping and homogenizing operations present a tolerably homogeneous beam of enlarged dimension, so that specialty-characterizing may proceed on a dimensional scale that is greater than the corresponding dimension of ultimate surgical delivery to the eye, thereby enabling greater control of the quality of specialty-characterizing. Provision is made for selectively monitoring the quality of the homogeneity and/or of the specially-characterized beam, with further provision for automated cutoff of laser beam delivery to an eye in the event that quality is not within predetermined limits of tolerance.

Abstract: A conventional keratomileusis procedure is modified to the extent that a controlled tissue-ablating laser radiation is applied solely to the freshly cut part of the cornea that is left after severing the lenticle, the radiation being so controlled and characterized as to effect a volumetric removal of exclusively stromal tissue that, upon replacement of the lenticle over the thus-sculptured remainder of the cornea, a new and optically corrected curvature results.

Abstract: The invention contemplates removal of epithelium-layer material from the anterior surface of the cornea, as a step preparatory to sculpting laser surgery, wherein controlled ultraviolet irradiation of the cornea is operative to surgically ablate corneal tissue within an epithelium-free area which is in the optically used central region of the cornea. For corrective sculpting recurvatures involving relatively small diopter change, the sculpture proceeds via selectively distributed ultraviolet radiation to the epithelium-free area, with penetration essentially only or at least predominantly in the tissue of Bowman's membrane, thus achieving the corrected-curvature profile essentially only or predominantly in the tissue of Bowman's membrane.

Abstract: The invention contemplates removal of epithelium-layer material from the anterior surface of the cornea, as a step preparatory to laser surgery, wherein controlled ultraviolet irradiation of the cornea is operative to surgically ablate corneal tissue within an epithelium-free area which is in the optically used central region of the cornea; the control is such (1) as first to effect essentially uniform-depth removal of Bowman's membrane to the extent of exposing only stroma tissue within said central region, and then (2) to so selectively distribute the ultraviolet radiation to then-exposed stroma tissue as to effect in stroma tissue a predetermined sculpted corrective-curvature change in the optically used region. Other important pre-surgury and post-surgery procedural steps are disclosed, for greater assurance of a predictable curvature change through the sculpting laser surgery.

Abstract: The invention contemplates removal of epithelium-layer material from the anterior surface of the cornea, as a step preparatory to laser surgery, wherein controlled ultraviolet irradiation of the cornea is operative to surgically ablate corneal tissue within an epithelium-free area which is in the optically used central region of the cornea; the control is such as to effect a predetermined sculpted corrective-curvature change in the optically used region. Other important pre-surgery and post-surgery procedural steps are disclosed, for greater assurance of a predictable curvature change through the sculpting laser surgery.

Abstract: The invention contemplates controlled ablation of the cornea, using ultraviolet laser radiation, wherein irradiated flux density and exposure time are so controlled as to achieve desired depth of the ablation. Sculpturing action results from controlled change of projected laser-spot size, in the course of a given treatment, wherein, in one illustrative case, projected laser-spot size ranges from a maximum which covers the entire area to be treated, down to a predetermined minimum tolerable size, wherein cornea-curvature change is myopia-corrective. Further illustrative techniques and situations are also disclosed, for achievement of hyperopia correction, for astigmatism correction, and in connection with corneal-transplant operations.