Patents by Inventor Francis Barth

Francis Barth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,3,5-triazine-2-amine derivatives, preparation thereof and diagnostic and therapeutic use thereof
    Patent number: 9115121
    Abstract: The present invention relates to compounds corresponding to formula (I) in which: —R1 represents a substituted phenyl; —R2 represents: —a substituted phenyl; —a heteroaromatic group, the said group being unsubstituted or substituted one or more times; —R3 represents a group Alk; —R4 represents a hydrogen atom or a (C1-C4)alkyl; —R5 represents a hydrogen atom, a (C3-C6)cycloalkyl or a (C1-C4)alkyl-O-Alk; —or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; —R6 represents a group —COOAlk, a group —CONH2 or a group —NHSO2Alk; —Alk represents a (C1-C4)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: August 25, 2015
    Assignee: Sanofi
    Inventors: Joelle Arnaud, Martine Artiaga, Francis Barth, Laurent Hortala, Serge Martinez, Pascale Roux
  • 1,3,5 -Triazine-2-Amine Derivatives, Preparation Thereof And Diagnostic And Therapeutic Use Thereof
    Publication number: 20140343061
    Abstract: The present invention relates to compounds corresponding to formula (I) in which: —R1 represents a substituted phenyl; —R2 represents: —a substituted phenyl; —a heteroaromatic group, the said group being unsubstituted or substituted one or more times; —R3 represents a group Alk; —R4 represents a hydrogen atom or a (C1-C4)alkyl; —R5 represents a hydrogen atom, a (C3-C6)cycloalkyl or a (C1-C4)alkyl-O-Alk; —or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; —R6 represents a group —COOAlk, a group —CONH2 or a group —NHSO2Alk; —Alk represents a (C1-C4)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use.
    Type: Application
    Filed: December 11, 2012
    Publication date: November 20, 2014
    Inventors: Joelle Arnaud, Martine Artiaga, Francis Barth, Laurent Hortala, Serge Martinez, Pascale Roux
  • Pyrrole derivatives, their preparation and their therapeutic application
    Patent number: 8680102
    Abstract: The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: March 25, 2014
    Assignee: Sanofi
    Inventors: Francis Barth, Daniel Bichon, Murielle Rinaldi-Carmona, Christian Congy
  • Thiophene-2-carboxamide derivatives, preparation thereof and therapeutic use thereof
    Patent number: 8410137
    Abstract: The subject matter of the invention is compounds corresponding to formula (I), in which: R1 and R2, together with the nitrogen atom to which they are attached, constitute a saturated heterocyclic radical containing from 4 to 7 atoms, which is preferably substituted; one of the two substituents R3 and R6 is a group Y-A-R9; Y is an oxygen atom or an —S(O)n?—, or —OSO2 group; A is an unsubstituted (C1-C4) alkylene group; R9 is an —OR19, —CH3, —NR19R20, —CONR19R20, —NR15COR19, —S(O)nR21, or —NR13SO2R21 group; —R10 is a hydrogen atom or a (C1-C4) alkyl group. The present invention also relates to the methods of preparation and the therapeutic uses of the compounds of formula (I).
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: April 2, 2013
    Assignee: Sanofi
    Inventors: Francis Barth, Jean-Philippe Ducoux, Patrick Gueule, Murielle Rinaldi-Carmona, Arnaud Rouquette
  • Pyrrole derivatives, preparation of same and therapeutic application thereof
    Patent number: 8383666
    Abstract: The subject of the invention is Compound of Formula (I): in which R1-R8 and R10 are defined within, its method of preparation, and its therapeutic application.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: February 26, 2013
    Assignee: Sanofi
    Inventors: Francis Barth, Audrey Jeanjean, Murielle Rinaldi-Carmona, Christian Congy
  • Substituted N-(4-cyano-1-pyrazol-3-yl)methylamine derivatives, preparation thereof and therapeutic use thereof
    Patent number: 8088797
    Abstract: The present invention relates to compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as defined herein. The invention further relates to preparation and therapeutic use of these compounds.
    Type: Grant
    Filed: June 24, 2009
    Date of Patent: January 3, 2012
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Murielle Rinaldi-Carmona, Martine Vernhet
  • Pyrrole derivatives, preparation thereof and therapeutic use thereof
    Patent number: 8044072
    Abstract: The invention relates to compounds having the formula (I): Wherein R1, R2, R3, R4, R5, R6, R7 and R8 and A-R9 are as defined herein. Also disclosed are the preparative methods for the compounds of formula (I) and their use in therapy.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: October 25, 2011
    Assignee: Sanofi Aventis
    Inventors: Francis Barth, Christian Congy, Laurent Hortala, Murielle Rinaldi-Carmona
  • THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    Publication number: 20110183960
    Abstract: The subject matter of the invention is compounds corresponding to formula (I), in which: R1 and R2, together with the nitrogen atom to which they are attached, constitute a saturated heterocyclic radical containing from 4 to 7 atoms, which is preferably substituted; one of the two substituents R3 and R6 is a group Y-A-R9; Y is an oxygen atom or an —S(O)n?—, or —OSO2 group; A is an unsubstituted (C1-C4) alkylene group; R9 is an —OR19, —CH3, —NR19R20, —CONR19R20, —NR15COR19, —S(O)nR21, or —NR13SO2R21 group; —R10 is a hydrogen atom or a (C1-C4) alkyl group. The present invention also relates to the methods of preparation and the therapeutic uses of the compounds of formula (I).
    Type: Application
    Filed: July 30, 2009
    Publication date: July 28, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Francis Barth, Jean-Philippe Ducoux, Patrick Gueule, Murielle Rinaldi-carmona, Arnaud Rouquette
  • PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
    Publication number: 20110152320
    Abstract: The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.
    Type: Application
    Filed: November 9, 2010
    Publication date: June 23, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Francis Barth, Daniel Bichon, Murielle Rinaldi-Carmona, Christian Congy
  • PYRROLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC APPLICATION THEREOF
    Publication number: 20110144157
    Abstract: The subject of the invention is Compound of Formula (I): in which R1-R8 and R10 are defined within, its method of preparation, and its therapeutic application.
    Type: Application
    Filed: November 9, 2010
    Publication date: June 16, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Francis BARTH, Audrey JEANJEAN, Murielle RINALDI-CARMONA, Christian CONGY
  • Pyrrole derivatives, intermediates therefor, preparation and therapeutic use thereof
    Patent number: 7879902
    Abstract: The invention concerns compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The invention also concerns the method for preparing said compounds including the intermediates therefor and their therapeutic use.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: February 1, 2011
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Laurent Hortala, Murielle Rinaldi-Carmona
  • Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl] sulfonamide, their preparation and their application in therapeutics
    Patent number: 7875646
    Abstract: The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
    Type: Grant
    Filed: September 21, 2007
    Date of Patent: January 25, 2011
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Philippe Pointeau, Murielle Rinaldi-Carmona
  • Diaryl triazolmethylamine derivatives, preparation and therapeutic use thereof
    Patent number: 7781471
    Abstract: The invention concerns compounds of formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also concerns a method for preparing same and the therapeutic use thereof.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: August 24, 2010
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Murielle Rinaldi-Carmona
  • 3-Acylindole derivatives, preparation and therapeutic use thereof
    Patent number: 7741363
    Abstract: The invention relates to compounds of formula (I), wherein X, R1, R2, R3, R4 and R5 are as described herein. The invention also includes preparative methods for the preparation of compounds of formula (I). A method for the therapeutic use of the inventive compounds is also disclosed and claimed.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: June 22, 2010
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Claude Vernhet, Murielle Rinaldi-Carmona, CaroleElisabeth Guillaumont-Legeay
  • 1-BENZYLPYRAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    Publication number: 20100144818
    Abstract: The present invention relates to compounds corresponding to formula (I): in which Y, R1, R2, R3, R4, R5 and R6 are as defined herein. The present invention also relates to the methods of preparation and the therapeutic applications of the compounds of formula (I).
    Type: Application
    Filed: December 3, 2009
    Publication date: June 10, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Francis BARTH, Laurent BOULU, Joseph MILLAN, Murielle RINALDI-CARMONA
  • N-[(4,5-DIPHENYL-2-THIENYL)METHYL]AMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
    Publication number: 20100137402
    Abstract: The subject of the present invention is compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also relates to a method for the preparation and application of said compounds as cannabinoid CB1 receptor antagonists.
    Type: Application
    Filed: February 8, 2010
    Publication date: June 3, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Jean-Philippe DUCOUX, Francis BARTH, Murielle RINALDI-CARMONA, Christian CONGY
  • N-[(4,5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application
    Patent number: 7687537
    Abstract: The subject of the present invention is compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also relates to a method for the preparation and application of said compounds as cannabinoid CB1 receptor antagonists.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: March 30, 2010
    Assignee: Sanofi-Aventis
    Inventors: Jean-Philippe Ducoux, Francis Barth, Murielle Rinaldi-Carmona, Christian Congy
  • N-[(4,5-diphenyl-3-alkyl-2-thienyl)methyl]amine [amide, sulfonamide, carbamate and urea) derivatives as cannabinoid CB1 receptor antagonists
    Patent number: 7674821
    Abstract: The invention concerns compounds of formula (I), wherein X, R1, R2, R3, R4 and R5 are as defined herein. The invention also concerns a method for preparing said compounds and their use as cannabinoid CB1 receptor antagonists.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: March 9, 2010
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Jean-Phillipe Ducoux, Murielle Rinaldi-Carmona
  • SUBSTITUTED N-(4-CYANO-1H-PYRAZOL-3-YL)METHYLAMINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    Publication number: 20100041709
    Abstract: The present invention relates to compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as defined herein. The invention further relates to preparation and therapeutic use of these compounds.
    Type: Application
    Filed: June 24, 2009
    Publication date: February 18, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Francis BARTH, Christian Congy, Serge Martinez, Murielle Rinaldi-Carmona, Martine Vernhet
  • (1,5-diphenyl-1-pyrazol-3-yl)oxadiazole derivatives, preparation method thereof and use of same in therapeutics
    Patent number: 7632852
    Abstract: The invention relates to compounds having formula (I): Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to a method of preparing said compounds and to the application thereof in therapeutics.
    Type: Grant
    Filed: August 8, 2007
    Date of Patent: December 15, 2009
    Assignee: Sanofi-aventis
    Inventors: Francis Barth, Christian Congy, Patrick Gueule, Murielle Rinaldi-Carmona, Didier Van Broeck