Patents by Inventor Francis John Tinney

Francis John Tinney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Octapeptides and methods for their production
    Patent number: 4101537
    Abstract: New octapeptides having the formula X-R.sup.1 -Trp-Ser(benzyl)-Tyr(benzyl)-R.sup.2 -Leu-Arg(R)-Pro-R.sup.3 -Y wherein X is a protective group, R is hydrogen or a protective group, R.sup.1 is a single bond, Gln, D-Leu or D-Val, R.sup.2 is D-Phe or D-Ala, R.sup.3 is a single bond or Gly and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: April 7, 1977
    Date of Patent: July 18, 1978
    Assignee: Parke, Davis & Company
    Inventors: Ernest D. Nicolaides, Francis John Tinney
  • Octapeptides and methods for their production
    Patent number: 4093611
    Abstract: New octapeptides having the formula X-R-Pro-His(benzyl)-His(benzyl)-R.sup.1 -Trp-D-Ala-Y wherein X is a protective group, R is Pro or Gln; R.sup.1 is Tyr(benzyl)-Ser(benzyl) or Ser(benzyl)-Pro and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: April 7, 1977
    Date of Patent: June 6, 1978
    Assignee: Parke, David & Company
    Inventor: Francis John Tinney
  • New heptapeptides and methods for their production
    Patent number: 4087416
    Abstract: New heptapeptides having the formula X-R-His(benzyl)-His(benzyl)--R.sup.1 --R.sup.2 --Trp--Ala--Y wherein X is a protective group, R is Pro or Gln; R.sup.1 and R.sup.2 are Ser(benzyl) or Tyr(benzyl) and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)-amino.
    Type: Grant
    Filed: November 5, 1976
    Date of Patent: May 2, 1978
    Assignee: Parke, Davis & Company
    Inventors: Francis John Tinney, Ernest D. Nicolaides
  • Hexapeptides and methods for their production
    Patent number: 4087417
    Abstract: New hexapeptides having the formula X-Trp-His-(benzyl)-Ser(benzyl)-Tyr(benzyl)-Pro-Ala-Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: September 15, 1976
    Date of Patent: May 2, 1978
    Assignee: Parke, Davis & Company
    Inventor: Francis John Tinney
  • Heptapeptides and methods for their production
    Patent number: 4087419
    Abstract: New heptapeptides having the formula X-Ser(benzyl)-Tyr(benzyl)-Phe-Leu-Arg(R)-Pro-Gly-Y wherein X is a protective group, R is a protective group and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: November 5, 1976
    Date of Patent: May 2, 1978
    Assignee: Parke, Davis & Company
    Inventor: Francis John Tinney
  • Hexapeptides and methods for their production
    Patent number: 4085096
    Abstract: New hexapeptides having the formula X-R-Trp-His(benzyl)-Tyr(benzyl)-Ser(benzyl)-R.sup.1 -Ala-Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single bond, His, His(benzyl) or Gln; R.sup.1 is a single bond or Pro and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino with the proviso that the total number of amino acid units when R and R.sup.1 are combined is one.
    Type: Grant
    Filed: September 15, 1976
    Date of Patent: April 18, 1978
    Assignee: Parke, Davis & Company
    Inventors: Francis John Tinney, Ernest D. Nicolaides
  • Hexapeptides
    Patent number: 4075189
    Abstract: New hexapeptides having the formula X-Pro-His(benzyl)-His(benzyl)-R-Trp-Ala-Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is Ser(benzyl) or Tyr(benzyl) and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: September 15, 1976
    Date of Patent: February 21, 1978
    Assignee: Parke, Davis & Company
    Inventor: Francis John Tinney
  • Pentapeptides and methods for their production
    Patent number: 4062835
    Abstract: New pentapeptides having the formula X-R-Tyr(methyl)-Ser(benzyl)-R.sup.1 -Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single amino acid fragment, a dipeptide fragment or tripeptide fragment utilizing amino acids selected from the group consisting of Pro, Aze, His(benzyl) and Trp; R.sup.1 is a single bond or a single amino acid fragment or a dipeptide fragment utilizing amino acids selected from the group consisting of Ala, Trp and His and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino with the proviso that the total number of amino acid units when R and R.sup.1 are combined is three.
    Type: Grant
    Filed: June 23, 1976
    Date of Patent: December 13, 1977
    Assignee: Parke, Davis & Company
    Inventor: Francis John Tinney
  • Pentapeptides and methods for their production
    Patent number: 4058513
    Abstract: New pentapeptides having the formula X-R-His(benzyl)-His(benzyl)-R.sup.1 -Trp-R.sup.2 -Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single bond or Pro; R.sup.1 is Ser(benzyl) or Tyr(benzyl), R.sup.2 is a single bond or Ala and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino with the proviso that the total number of amino acid units when R and R.sup.2 are combined is one.
    Type: Grant
    Filed: June 23, 1976
    Date of Patent: November 15, 1977
    Assignee: Parke, Davis & Company
    Inventor: Francis John Tinney
  • New pentapeptides and methods for their production
    Patent number: 4043993
    Abstract: New pentapeptides having the formula X-R-Tyr-(benzyl)-Ser(benzyl)-R.sup.1 -Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single amino acid fragment, a dipeptide fragment or tripeptide fragment utilizing amino acids selected from the group consisting of Pro, Aze, His-(benzyl) and Trp; R.sup.1 is a single bond or a single amino acid fragment or a dipeptide fragment utilizing amino acids selected from the group consisting of Ala, Trp and His and Y is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino with the proviso that the total number of amino acid units when R and R.sup.1 are combined is three.
    Type: Grant
    Filed: June 23, 1976
    Date of Patent: August 23, 1977
    Assignee: Parke, Davis & Company
    Inventors: Francis John Tinney, Ernest D. Nicolaides, Alfred Campbell
  • Tetrapeptides and methods for their production
    Patent number: 4035348
    Abstract: New tetrapeptides having the formula A-R.sub.1 -Tyr(benzyl)-Ser(benzyl)-D-Ala-R.sub.2 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; R.sub.1 is L-His(benzyl), D-Pro, or L-Trp; Tyr(benzyl) is D-Tyr-(benzyl) or L-Tyr(benzyl); Ser(benzyl) is D-ser(benzyl) or L-Ser(benzyl) and R.sub.2 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: July 12, 1977
    Assignee: Parke, Davis & Company
    Inventors: Francis John Tinney, Ernest D. Nicolaides
  • Tetrapeptides
    Patent number: 4031069
    Abstract: New tetrapeptides having the formula A-R.sub.1 -Ser(benzyl)-Tyr(benzyl)-R.sub.2 -R.sub.3 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; R.sub.1 is L-Trp, L-Thr(benzyl), L-Met or Gly; Ser(benzyl) is D-Ser(benzyl) or L-Ser(benzyl); Tyr(benzyl) is D-Tyr(benzyl) or L-Tyr(benzyl); R.sub.2 is D-Ala, .beta.-Ala, D-Leu or D-Val; and R.sub.3 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: June 21, 1977
    Assignee: Parke, Davis & Company
    Inventors: Ernest D. Nicolaides, Francis John Tinney, James Clark French
  • Tetrapeptides
    Patent number: 4031070
    Abstract: New tetrapeptides having the formula A-R.sub.1 -R.sub.2 -Ser(benzyl)-Tyr(benzyl)-R.sub.3 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; R.sub.1 is L-Trp or L-His(benzyl); R.sub.2 is L-Trp or L-His(benzyl); Ser(benzyl) is D-Ser(benzyl) or L-Ser(benzyl); Tyr(benzyl) is D-Tyr(benzyl) or L-Tyr(benzyl); and R.sub.3 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: June 21, 1977
    Assignee: Parke, Davis & Company
    Inventor: Francis John Tinney
  • Tripeptides and methods for their production
    Patent number: 4022761
    Abstract: New tripeptides having the formula A-R.sub.1 -Ser(benzyl)-Tyr (benzyl)-R.sub.2 wherein A is t-butoxycarbonyl or cyclohexyl carbonyl, R.sub.1 is Trp, His(benzyl), Cys(benzyl) or Pro and R.sub.2 is lower alkoxy, hydrazino, amino, lower alkylamino, di(lower alkyl)amino, benzylamino, allylamino, (diethoxyphosphinyl)methylamino, 2-(diethoxyphosphinyl)ethylamino or 2-[[(phenylmethyl)amino]sulfonyl]ethylamino, methods for their production, and the use of said tripeptides as luteinizing hormone releasing factor antagonists.
    Type: Grant
    Filed: January 19, 1976
    Date of Patent: May 10, 1977
    Assignee: Parke, Davis & Company
    Inventors: Francis John Tinney, Ernest D. Nicolaides, Marland Paul Hutt, Thomas Frederick Mich
  • Tripeptides and methods for their production
    Patent number: 4022759
    Abstract: New tripeptides having the formula A-R.sub.1 -Tyr(benzyl)-Ser(benzyl)-R.sub.2 wherein A is t-butoxycarbonyl or cyclohexylcarbonyl, R.sub.1 is Trp, His(benzyl), Cys(benzyl) or Pro and R.sub.2 is lower alkoxy, hydrazino, amino, lower alkylamino, di(lower alkyl)amino, benzylamino, allylamino, (diethoxyphosphinyl)methylamino, 2-(diethoxyphosphinyl)ethylamino or 2-[[(phenylmethyl)amino]sulfonyl]ethylamino, methods for their production, and the use of said tripeptides as luteinizing hormone releasing factor antagonists.
    Type: Grant
    Filed: January 19, 1976
    Date of Patent: May 10, 1977
    Assignee: Parke, Davis & Company
    Inventors: Francis John Tinney, Alfred Campbell
  • Tripeptides and methods for their production
    Patent number: 4022760
    Abstract: New tripeptides having the formula A-R.sub.1 -Tyr(benzyl)-Thr(benzyl)-R.sub.2 wherein A is t-butoxycarbonyl or cyclohexylcarbonyl, R.sub.1 is Trp, His(benzyl), Cys(benzyl) or Pro and R.sub.2 is lower alkoxy, hydrazino, amino, lower alkylamino, di(lower alkyl)amino, benzylamino, allylamino, (diethoxyphosphinyl)methylamino, 2-(diethoxyphosphinyl)ethylamino or 2-[[(phenylmethyl)amino]sulfonyl]ethylamino, methods for their production, and the use of said tripeptides as luteinizing hormone releasing factor antagonists.
    Type: Grant
    Filed: January 19, 1976
    Date of Patent: May 10, 1977
    Assignee: Parke, Davis & Company
    Inventor: Francis John Tinney