Patents by Inventor Francis Szoka

Francis Szoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extracellular matrix binding chimeric proteins and methods of use thereof
    Publication number: 20060239965
    Abstract: The present invention provides chimeric polypeptides comprising a first polypeptide that binds to a component of extracellular matrix and a second polypeptide that provides for a therapeutic effect. The present invention further provides compositions, including pharmaceutical compositions, comprising a subject chimeric polypeptide. A subject chimeric polypeptide is useful in a variety of treatment, diagnostic, and research applications, which are also provided.
    Type: Application
    Filed: February 28, 2006
    Publication date: October 26, 2006
    Inventors: Francis Szoka, Joshua Park, Robert Stull
  • Liposome drug delivery method and composition
    Patent number: 4873088
    Abstract: A method for enhancing the therapeutic effectiveness of adriamycin, in the treatment of cancer, is disclosed. Liposomes containing coentrapped adriamycin and a secondary compound effective to reduce the toxicity of adriamycin or enhance the induction by adriamycin of the tumoricidal activity of host lymphoid cells, such as lipopolysaccharide, are administered parenterally in a therapeutically effective dose. In another aspect, macrophages stimulated in vivo with liposomes containing entrapped liposomes are exposed to an immunostimulator, for enhanced tumoricidal activity. Also disclosed are liposome compositions containing coentrapped adriamycin and an immunostimulator.
    Type: Grant
    Filed: July 13, 1987
    Date of Patent: October 10, 1989
    Assignee: Liposome Technology, Inc.
    Inventors: Eric Mayhew, M. Jane Ehrke, Kenneth Mace, Francis Szoka, Fred C. Olson