Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: Implementations are described herein for leveraging an agricultural knowledge graph to generate messages automatically. In various implementations, an agricultural event may trigger proactive performance of one or more of the following operations. Nodes of the agricultural knowledge graph may be identified as related to the agricultural event, including field node(s) representing subject agricultural field(s) to which the agricultural event is relevant and other node(s) connected to one or more of the field nodes by edge(s). Machine learning model(s) may be accessed based on the identified nodes and/or the edges that connect the identified nodes. Data relevant to the subject agricultural field(s) may be retrieved from data source(s) controlled by an agricultural entity and processed based on the machine learning model(s) to generate inference(s) about the subject agricultural field(s).

Abstract: The present disclosure provides methods for treating hematological malignancies and Ewings sarcoma using menin inhibitors. Compositions for use in these methods are also provided.

Abstract: Systems and processes for removing a first sulfur compound from a hydrocarbon stream. The systems and process utilize at least one reaction vessel incorporating a hydrolysis catalyst suitable for hydrolyzing the first sulfur compound to a second sulfur compound. The reaction vessel also incorporates a sorbent material suitable for absorbing the second sulfur compound. Following hydrolysis of the first sulfur compound to the second sulfur compound and absorption of the second sulfur compound, a hydrocarbon-containing stream having a reduced sulfur content is produced. The hydrolysis catalyst and sorbent material may be provided in separate zones within the reaction vessel or provided as a mixture in a single zone. The hydrocarbon-containing stream having a reduced sulfur content is suitable for a variety of uses, including as a feedstreams for hydrogen plants, process gas streams for power generation plants, or for other uses for hydrocarbon-containing stream having reduced sulfur content.

Abstract: A multiple effect pyrotechnic shell (20), having a lift chamber (22), primary break (24), secondary break (26), and a tertiary break (28) has a desired weight distribution to inhibit tumbling. The secondary break weight is less than the primary break weight, and the tertiary break weight is less than both the primary and secondary break weights. Thus, the center of gravity of the shell (20) is positioned below a midpoint of the shell height. A first timing fuse (46) extends from a lift charge (30) into a primary break charge (50A) of the primary break (24), and a primary internal timing fuse (64) extends from the primary break (24) to the secondary break (26). Further, a secondary internal timing fuse (70) extends from the secondary break (26) to the tertiary break (28). Fuse fragments (52) are preferably disbursed within the break hulls (48) to provide filler and add an additional effect to each break (24-28).

Abstract: A multiple effect pyrotechnic shell (20), having a lift chamber (22), primary break (24), secondary break (26), and a tertiary break (28) has a desired weight distribution to inhibit tumbling. The secondary break weight is less than the primary break weight, and the tertiary break weight is less than both the primary and secondary break weights. Thus, the center of gravity of the shell (20) is positioned below a midpoint of the shell height. A first timing fuse (46) extends from a lift charge (30) into a primary break charge (50A) of the primary break (24), and a primary internal timing fuse (64) extends from the primary break (24) to the secondary break (26). Further, a secondary internal timing fuse (70) extends from the secondary break (26) to the tertiary break (28). Fuse fragments (52) are preferably disbursed within the break hulls (48) to provide filler and add an additional effect to each break (24-28).