Abstract: CRISPNA, a new tool for genome editing and diagnosis. The present invention relates to methods and systems for genome editing and diagnosis, and specifically relates to use of Peptide Nucleic Acids (PNAs) to direct the Cas proteins to their DNA or RNA targets.

Abstract: The invention provides methods for detecting a cellular proliferative disorder (e.g., urothelial cancer) in a subject by assessing the methylation status of the CCND2, CCNA1 or CALCA promoter in a nucleic acid sample. The methods of the invention are useful for diagnostic, prognostic as well therapeutic regimen predictions.

Abstract: Methods and apparatus for detecting fraudulent traffic associated with a user of a telecommunications system. A system comprises a monitoring network node comprising a traffic monitor configured to monitor traffic transmitted to or from a user in the telecommunications system, a fraud detector configured to apply to the monitored traffic a fraud profile associated with the user to determine whether the monitored traffic comprises fraudulent traffic, a transmitter configured to transmit data to a receiver of a profiling network node notifying whether the monitored traffic comprises fraudulent traffic. The profiling network node further comprises a fraud profiler configured to determine an updated fraud profile associated with the user based at least on the received data and a transmitter configured to transmit data identifying the updated fraud profile to one or both of a receiver of a subscription profile repository and a receiver of the monitoring network node.

Abstract: An encapsulated insulating module for furnaces composed by two different quality materials, in which a regular quality insulating module is encapsulated or surrounded by a high quality insulating layer, wherein the regular quality insulating module is in direct contact with the surface of a hot portion of a furnace wall.

Abstract: Methods and apparatus for detecting fraudulent traffic associated with a user of a telecommunications system. A system comprises a monitoring network node comprising a traffic monitor configured to monitor traffic transmitted to or from a user in the telecommunications system, a fraud detector configured to apply to the monitored traffic a fraud profile associated with the user to determine whether the monitored traffic comprises fraudulent traffic, a transmitter configured to transmit data to a receiver of a profiling network node notifying whether the monitored traffic comprises fraudulent traffic. The profiling network node further comprises a fraud profiler configured to determine an updated fraud profile associated with the user based at least on the received data and a transmitter configured to transmit data identifying the updated fraud profile to one or both of a receiver of a subscription profile repository and a receiver of the monitoring network node.

Abstract: A wire puzzle comprising two elements. The first of such elements is a length of wire configured to include a plurality of serpentine loops, the entire length of wire forming a closed circuit. The second of such elements is a length of wire formed to provide at least three loops, the length of wire having a free end which terminates in spaced relation to a segment of the wire which has been bent to form the first of such loops and then the second. The wire segment, after formation of the first and second loops runs generally parallel to the segment terminating in the free end and thereafter forms the third loop about said first loop. By manipulation of the first element and its serpentine loops with respect to the three loops of the second element the two elements may be connected and disconnected without forcing.