Patents by Inventor Franco Pagani

Franco Pagani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified human U1snRNA molecule, a gene encoding for the modified human U1snRNA molecule, an expression vector including the gene, and the use thereof in gene therapy of familial dysautonomia and spinal muscular atrophy
    Patent number: 9669109
    Abstract: The invention provides a modified human U1snRNA molecule, capable of correcting the skipping of an exon caused by a mutation localized in the sequence comprised between 50 base pairs upstream and 20 base pairs downstream of an exon, wherein a portion of a single-stranded nucleotide sequence of the 5? region of the wild-type human U1snRNA is replaced by a single-stranded binding nucleotide sequence, wherein the binding nucleotide sequence is selected from the group consisting of: uggcgcuua, aauggcgcu, aguacaauggcgc (SEQ ID NO: 87), gcaaacaguacaau (SEQ ID NO: 88), ucgcaaacaguaca (SEQ ID NO: 89), gcaaacagu, cuagucgcaaac (SEQ ID NO: 90), uacaaaaguaagauuca (SEQ ID NO: 83), aaaccauaaaguuuuacaa (SEQ ID NO: 84) and caaaccauaaaguuuua (SEQ ID NO: 96).
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: June 6, 2017
    Assignee: UNIVERSITA DI FERRARA
    Inventors: Franco Pagani, Mirko Pinotti
  • MODIFIED HUMAN U1SNRNA MOLECULE, A GENE ENCODING FOR THE MODIFIED HUMAN U1SNRNA MOLECULE, AN EXPRESSION VECTOR INCLUDING THE GENE, AND THE USE THEREOF IN GENE THERAPY OF FAMILIAL DYSAUTONOMIA AND SPINAL MUSCULAR ATROPHY
    Publication number: 20170143847
    Abstract: The invention provides a modified human U1snRNA molecule, capable of correcting the skipping of an exon caused by a mutation localized in the sequence comprised between 50 base pairs upstream and 20 base pairs downstream of an exon, wherein a portion of a single-stranded nucleotide sequence of the 5? region of the wild-type human U1snRNA is replaced by a single-stranded binding nucleotide sequence, wherein the binding nucleotide sequence is selected from the group consisting of: uggcgcuua, aauggcgcu, aguacaauggcgc (SEQ ID NO: 87), gcaaacaguacaau (SEQ ID NO: 88), ucgcaaacaguaca (SEQ ID NO: 89), gcaaacagu, cuagucgcaaac (SEQ ID NO: 90), uacaaaaguaagauuca (SEQ ID NO: 83), aaaccauaaaguuuuacaa (SEQ ID NO: 84) and caaaccauaaaguuuua (SEQ ID NO: 96).
    Type: Application
    Filed: November 24, 2015
    Publication date: May 25, 2017
    Inventors: FRANCO PAGANI, MIRKO PINOTTI
  • Modified human U1snRNA molecule, a gene encoding for the modified human U1snRNA molecule, an expression vector including the gene, and the use thereof in gene therapy
    Patent number: 9074207
    Abstract: A modified human U1snRNA molecule is described, the target sequence of which is located in a region of the pre-mRNA of the target gene comprised between 2 and 50 base pairs downstream of an exon/intron junction site, which is capable of restoring the correct splicing of a target gene of therapeutic interest bearing a mutation which induces exon skipping and resulting in a genetic disease. Modified human U1snRNA molecules are described by way of example for the correction of diseases associated with exon skipping, such as spinal muscular atrophy, hemophilia B, and cystic fibrosis.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: July 7, 2015
    Assignee: UNIVERSITA′ DEGLI STUDI DI FERRARA
    Inventors: Franco Pagani, Mirko Pinotti
  • MODIFIED HUMAN U1SNRNA MOLECULE, A GENE ENCODING FOR THE MODIFIED HUMAN U1SNRNA MOLECULE, AN EXPRESSION VECTOR INCLUDING THE GENE, AND THE USE THEREOF IN GENE THERAPY
    Publication number: 20130210902
    Abstract: A modified human U1snRNA molecule is described, the target sequence of which is located in a region of the pre-mRNA of the target gene comprised between 2 and 50 base pairs downstream of an exon/intron junction site, which is capable of restoring the correct splicing of a target gene of therapeutic interest bearing a mutation which induces exon skipping and resulting in a genetic disease. Modified human U1snRNA molecules are described by way of example for the correction of diseases associated with exon skipping, such as spinal muscular atrophy, hemophilia B, and cystic fibrosis.
    Type: Application
    Filed: October 14, 2011
    Publication date: August 15, 2013
    Applicant: UNIVERSITA' DEGLI STUDI DI FERRARA
    Inventors: Franco Pagani, Mirko Pinotti
  • Exercising device
    Patent number: 4373716
    Abstract: The exercising device includes a rigid central rod having transverse rigid headers fixedly connected at the ends of the rod. At least two strands of extensible cord are attached at their end portions to the rod. At least one end portion of each strand is releasably secured to the rod whereby a large number of different exercising devices may be performed.
    Type: Grant
    Filed: December 17, 1979
    Date of Patent: February 15, 1983
    Inventor: Franco Pagani
  • Cigarette puncher
    Patent number: 4250899
    Abstract: A cigarette puncher comprising a body member having a clip portion and a punch support portion, an elongated guide slot in the body member has a width permitting the snug insertion of the end of a cigarette therein and an elongated punch member is mounted in one end of the elongated guide slot. In one embodiment, plural punch members are provided on a rotary turret. In a second embodiment, a single punch is provided on the lower end of a cigarette light connected to the clip portion. In both embodiments, the clip portion is dimensioned to be received in one end of a cigarette pack.
    Type: Grant
    Filed: July 3, 1979
    Date of Patent: February 17, 1981
    Inventor: Franco Pagani