Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: A turbomachine blade is made of composite material formed of woven fibers and embedded in a polymerised resin. The blade includes a root connected by a stilt to a vane which comprises a pressure side and a suction side. At least one anti-wear strip of fabric is located on a surface of the root and/or the stilt. At least one anti-wear strip is secured to the root surface in a unitary manner by the resin.

Abstract: The invention provides methods and systems for generating an ultrasound image. In a method, the generation of an ultrasound image comprises: obtaining channel data, the channel data defining a set of imaged points; for each imaged point: isolating the channel data; performing a spectral estimation on the isolated channel data; and selectively attenuating the spectral estimation channel data, thereby generating filtered channel data; and summing the filtered channel data, thereby forming a filtered ultrasound image. In some examples, the method comprises aperture extrapolation. The aperture extrapolation improves the lateral resolution of the ultrasound image. In other examples, the method comprises transmit extrapolation. The transmit extrapolation improves the contrast of the image. In addition, the transmit extrapolation improves the frame rate and reduces the motion artifacts in the ultrasound image. In further examples, the aperture and transmit extrapolations may be combined.

Abstract: A system for preparing an ankle bone to receive an ankle prosthesis is provided. The system includes a patient specific cutting guide that has an anterior surface, a posterior surface, and at least one cutting feature extending through the guide from the anterior surface. The posterior surface comprising a first protrusion or other member that extends from a first end fixed to the posterior surface to a second end disposed away from the first end of the first protrusion. The posterior surface has a second protrusion or other member that extends from a first end fixed to the posterior surface to a second end disposed away from the first end of the second protrusion. The first and second protrusions are spaced apart and have a length such that when the patient specific cutting guide is coupled with first and second bone references, which can include bushings implantable in bones, a clearance gap is provided between the posterior surface and the ankle bone.

Abstract: Disclosed is a process and a device for sterilizing gas filtration unit, characterized in that the sterilization process includes at least: —an application step consisting in circulating, through the gas filtration unit, a gas mixture including hot air and a determined amount of hydrogen peroxide vapor, in which the determined amount of hydrogen peroxide vapor is obtained by sequentially injecting, with a given time interval (t) between two successive injections, a given dose of hydrogen peroxide in the liquid state into the hot air; and —a sterilization step consisting, during the time interval (t), in circulating hot air through the filtration unit in order to eliminate, by evaporation, all or some of the hydrogen peroxide deposited on the filtration unit during the application step.

Abstract: Systems, methods, and apparatuses for confidence mapping of shear wave measurements are disclosed. Confidence maps of shear wave image measurements may be generated from one or more confidence factors. Masking of graphical overlays of tissue stiffness values, based at least in part on the confidence map is disclosed. The confidence map and/or masked graphical overlays of tissue stiffness values may be superimposed on ultrasound images and provided on a display.

Abstract: The present disclosure describes ultrasound imaging systems and methods configured to generate ultrasound images based on undersampled ultrasound data. The ultrasound images may be generated by applying a neural network trained with samples of known fully sampled data and undersampled data derived from the known fully sampled data to a acquired sparsely sampled data. The training of the neural network may involve training adversarial generative network including a generator and a discriminator. The generator is trained with sets of known undersampled data until the generator is capable of generating estimated image data, which the classifier is incapable of differentiation as either real or fake, and the trained generator may then be applied to unknown undersampled data.

Abstract: Systems and methods for encoding radiofrequency, RF, data, e.g., electrical signals, by a microbeamformer are disclosed herein. The microbeamformer may use a pseudo-random sampling pattern (700) to sum samples of the RF data stored in a plurality of memory cells. The memory cells may be included in a delay line of the microbeamformer in some examples. The summed samples may form an encoded signal transmitted to a decoder which reconstructs the original RF data from the encoded signal. The decoder may use knowledge of the pseudo-random sampling pattern to reconstruct the original data in some examples.

Abstract: Ultrasound image devices, systems, and methods are provided. An ultrasound imaging system, comprising an array of acoustic elements configured to transmit ultrasound energy into an anatomy and to receive ultrasound echoes associated with the anatomy; and a processor circuit in communication with the array of acoustic elements and configured to receive, from the array, ultrasound channel data corresponding to the received ultrasound echoes; normalize the ultrasound channel data by applying a first scaling function to the ultrasound channel data; generate beamformed data by applying a predictive network to the normalized ultrasound channel data; de-normalize the beamformed data by applying a second scaling function to the beamformed data; generate an image of the anatomy from the beamformed data; and output, to a display in communication with the processor circuit, the image of the anatomy.

Abstract: The present invention relates to a compound of formula (I) or a tautomer thereof, wherein R1, R2, R3, R4 and R5, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of epilepsy and/or neurodegenerative diseases.

Abstract: A system for guiding a glenoid prosthesis is disclosed. The system includes a glenoid guide that includes: a guide feature; at least three arms having a first end coupled with the guide feature and a second end disposed away from the guide feature; at least three peripheral pegs, each peripheral peg extending from the second end of a corresponding arm and includes an engagement surface configured to engage the scapula of the patient; and a strut extending laterally from the guide feature.

Abstract: Disclosed is a process and a device for sterilizing gas filtration unit, characterized in that the sterilization process includes at least: —an application step consisting in circulating, through the gas filtration unit, a gas mixture including hot air and a determined amount of hydrogen peroxide vapor, in which the determined amount of hydrogen peroxide vapor is obtained by sequentially injecting, with a given time interval (t) between two successive injections, a given dose of hydrogen peroxide in the liquid state into the hot air; and—a sterilization step consisting, during the time interval (t), in circulating hot air through the filtration unit in order to eliminate, by evaporation, all or some of the hydrogen peroxide deposited on the filtration unit during the application step.

Abstract: The present invention relates to an ultrasound system (10) comprising a first non-invasive ultrasound probe (14) configured to acquire first ultrasound data having a first field of view; a second invasive ultrasound probe (16) configured to acquire second ultrasound data having a second field of view which is different from the first field of view; a tracking unit (30) configured to determine tracking data comprising a position and orientation of the first non-invasive ultrasound probe (14) relative to the second invasive ultrasound probe (16); and a registration unit (32) configured to register the second field of view into the first field of view based on the tracking data.

Abstract: Systems, methods, and apparatuses for confidence mapping of shear wave measurements are disclosed. Confidence maps of shear wave image measurements may be generated from one or more confidence factors. Masking of graphical overlays of tissue stiffness values, based at least in part on the confidence map is disclosed. The confidence map and/or masked graphical overlays of tissue stiffness values may be superimposed on ultrasound images and provided on a display.

Abstract: A system predicts user intent to take an action and delivers content items to the user that match that intent. A plurality of features or attributes for each tracking pixel in a set of tracking pixels can be acquired based on content items and landing pages associated with each tracking pixel. For example, features for a tracking pixel can be determined based on information associated with a content item that enabled a user to access a landing page from which the tracking pixel was fired or triggered. In this example, features for the tracking pixel can also be determined based on information associated with the landing page. The features for the tracking pixels can be utilized to train a machine learning model. The machine learning model can be trained to predict whether or not a particular user intends to produce a conversion (e.g., make a purchase).

Abstract: An ultrasound imaging system includes an array of acoustic elements configured to transmit ultrasound energy at a first transmit speed and receive echoes associated with the ultrasound energy transmitted at the first transmit speed. The system further includes a processor circuit in communication with the array of acoustic elements. The processor is configured to generate a plurality of multilines based on the received echoes, determine a second transmit speed, determine a set of transmit focus delays based on the second transmit speed, adjust the plurality of multilines using the set of transmit focus delays, generate an image based on the adjusted plurality of multilines, and output the generated image to a display in communication with the processor circuit.

Abstract: The present invention relates to an ultrasound system. A first non-invasive ultrasound probe receives first ultrasound data having a first field of view and a second invasive ultrasound probe receives second ultrasound data having a second field of view which is different from the first field of view. A tracking unit determines tracking data including a position and orientation of the first non-invasive ultrasound probe relative to the second invasive ultrasound probe. A registration unit registers the second field of view into the first field of view based on the tracking data.

Abstract: In some examples, tissue types in B-mode images may be differentiated by multiparameter imaging and/or other segmentation techniques. The tissue types may be used to assign material properties to voxels of the B-mode image, such as color, translucency, and reflectivity. The material properties may be used to generate a rendered image. In some examples, one or more of the material properties assigned to the voxels may correspond to values of tissue parameters acquired during multiparameter imaging. The rendered image may include data based on both the B-mode image and the multiparameter imaging.

Abstract: Systems and methods for improving spectral-shift methods for calculating acoustic attenuation coefficients are disclosed. Systems, methods, and apparatuses for transmitting ultrasound pulse sequences for improved signal-to-noise outside the main passband of ultrasound transducers are disclosed. Systems, methods, and apparatuses for using the echoes from the transmitted pulse sequences to calculate the attenuation coefficient are disclosed.

Abstract: In some examples, received signals from certain multilines may be selectively filtered to remove aliased frequencies that may result in grating lobes in ultrasound images. In some examples, a transmit beam may be shaped to reduce spatial frequencies in received signals. In some examples, the width of the transmit beam may be adjusted based on a frequency of the transmit signal. In some examples, a focal depth of the transmit beam may be adjusted based on a frequency of the transmit signal.