Abstract: This disclosure provides immunogenic combinations that include a) an immunogenic component containing a peptide or polypeptide antigen of a respiratory pathogen; and b) an immunogenic component containing a nucleic acid encoding an antigen of the same respiratory pathogen, wherein the immunogenic components are formulated for concurrent, e.g., co-localized, administration. More specifically, the respiratory pathogen is respiratory syncytial virus (RSV). This disclosure also concerns provides the use of such immunogenic combinations, and methods for administering such immunogenic combinations to elicit an immune response specific for the respiratory pathogen.

Abstract: Immunogenic combinations that include a) an immunogenic component containing a peptide or polypeptide antigen of a respiratory pathogen; and b) an immunogenic component containing a nucleic acid encoding an antigen of the same respiratory pathogen, wherein the immunogenic components are formulated for concurrent administration are provided, as well as methods for making and for administering such immunogenic combinations to elicit an immune response specific for the respiratory pathogen.

Abstract: There is provided inter alia a method of treating cancer in a mammal, said method comprising the steps of: (i) administering to the mammal a first composition comprising an antigen or comprising a nucleic acid encoding an antigen and (ii) administering to the mammal a second composition comprising an oncolytic virus wherein the oncolytic virus comprises a nucleic acid encoding the antigen.

Abstract: Immunogenic combinations that include a) an immunogenic component containing a peptide or polypeptide antigen of a respiratory pathogen; and b) an immunogenic component containing a nucleic acid encoding an antigen of the same respiratory pathogen, wherein the immunogenic components are formulated for concurrent administration are provided, as well as methods for making and for administering such immunogenic combinations to elicit an immune response specific for the respiratory pathogen.

Abstract: Combination immunogenic compositions capable of eliciting protection against both RSV and B. pertussis infection and disease are provided, including compositions which comprise a recombinant F protein analog of RSV, together with B. pertussis acellular (Pa) or whole cell (Pw) antigens.

Abstract: The present disclosure provides immunogenic compositions for the prevention and/or treatment of disease caused by dengue virus.

Abstract: The present disclosure provides immunogenic compositions for the prevention and/or treatment of disease caused by dengue virus.

Abstract: This disclosure provides methods for protecting infants against disease caused by respiratory syncytial virus (RSV) and Bordetella pertussis through maternal immunization using recombinant respiratory syncytial virus (RSV) and B. pertussis antigens to reduce the incidence or severity of RSV and pertussis infection in young infants.

Abstract: The present disclosure provides immunogenic compositions for the prevention and/or treatment of disease caused by dengue virus.

Abstract: In order to prepare particles of a vitreous enamel for use in forming a vitreous enamel body by fusing the particles together to form the body, at least one enamel frit and at least one non-vitreous additive are formed into an agglomerated granular feedstock and passed through a heating chamber whereby such feedstock becomes at least partially molten and rounded, whereafter the resulting rounded vitreous enamel beads are caused or allowed to cool to a temperature below their melting point.

Abstract: A method of manufacturing a vitreous enamel body includes forming particles of vitreous material and melting to fuse the particles together to form the body. The particles of vitreous material are spherulized and are selected as to their granulometric properties according to the degree of compaction required in the finished enamel body. From 20% to 40% of the bulk volume of the mixture is a fine particle size fraction. Such a finished enamel body may be a coating, for example a high-compacity enamel coating on a bathtub, or it may be a self-sustaining body, for example a porous vitreous filter element. Porous coatings and compact self-sustaining bodies may also be made.

Abstract: A glass article useful, for example, as a cathode ray tube screen, has a viewing light path which passes through at least one surface region over which the glass is matted by surface pits whereby unwanted specular reflection from that matted region is reduced. The light path also passes through a surface layer formed over a region of the glass so as to reduce the total light reflection from that region of the glass.

Abstract: A fire control composition which is in particulate form, which is anhydrous, and which is particularly effective for fighting Class D fires, such as metal fires. The composition includes particles of crushed glass bearing a hydrophobic coating thereon so that agglomeration of the fire control composition due to adsorption of moisture during storage and use is substantially prevented and so that when applied to fire, the fire control composition forms a blanket over the fire which deprives the fire of oxygen and thereby smothers it. The composition may additionally contain at least one additional material, such as salts, spherulized vitreous beads, or graphite which at least one additional material also bears a hydrophobic coating. The median grain size of the crushed glass is preferably below 200 micrometers, most preferably below 120 micrometers, for example, in the range of from 25 to 35 micrometers.

Abstract: Glass microbeads bearing a coating which includes at least one binding agent fixed to the glass microbeads, and which binding agent is adapted releasably to bind to a material contained within a fluid medium by a biological affinity reaction, whereby the material can be removed from the fluid medium with the glass microbeads and then stripped from the glass microbeads while leaving the at least one binding agent attached to the glass microbeads. Inventive microbeads may bear a monomolecular layer of a silane as a fixing agent for a binding agent which is selected for its biological affinity for the material to be separated.

Abstract: A fire control composition in particulate form and containing no water, which is particularly effective for fighting metal fires, i.e., Class D fires, and which comprises particles of crushed glass bearing a hydrophobic coating thereon so that agglomeration of the fire control composition due to adsorption of moisture during storage and use is substantially prevented and so that when applied to fire, the fire control composition forms a blanket over the fire which deprives the fire of oxygen and thereby smothers it. The composition additionally contains one or more particulate adjuvants selected from salts and/or spherulized vitreous beads, which adjuvants also bear a hydrophobic coating. Useful adjuvants include graphite particles and salts. The median grain size of the crushed glass is below 200 micrometers, preferably below 120 micrometers, for example, in the range of from 25 to 35 micrometers.

Abstract: A transparent fire-screening glazing panel has at least one solid intumescent layer comprising a hydrated alkali metal silicate and at least one sheet of glazing material, and the layer of intumescent material contains at least one silicate-stabilizing agent. Suitable stabilizing compounds include at least partially dissociated nitrogenized organic compounds, especially quaternary ammonium compounds such as tetramethylammonium hydroxide. To manufacture such a panel, the silicate-stabilizing agent may be incorporated into an aqueous solution of the intumescent material which is then hardened by drying to form the layer. Alternatively, the silicate-stabilizing agent may be incorporated into an aqueous solution of the intumescent material which is then dried to form grains which are subsequently incorporated into a layer held sandwiched between two sheets of glazing material.

Abstract: A process of manufacturing vitreous beads is disclosed in which feedstock particles of a glass-former composition containing less than 15% by dry weight of sodium and potassium calculated as their respective oxides and containing chemically bound water, are fed through a heating zone in which the particles are vitrified and spherulized and the resulting vitreous beads are cooled. The vitrifiable oxide forming elements of said glass-former composition may be chemically interlinked, and the feedstock may be prepared as a silica-based gel or precipitate having a composition suitable for vitrification into a glass of a desired composition which by virtue of its low alkali content is resistant to hydrolytic attack. By control of the cellulating agent content (bound water and optionally a gas evolving salt radical such as nitrate or sulphate) of the feedstock, and its granulometry, the relative proportions of solid and hollow beads which will be produced in a given spherulizing run can be controlled.

Abstract: A process of manufacturing vitreous beads is disclosed in which feedstock particles of a glass-former composition containing chemically bound water, are fed through a heating zone in which the particles are vitrified and spherulized and the resulting vitreous beads are cooled. The size of the feedstock particles and their content of substance which becomes gaseous during the passage of the particles through said heating zone are such that a least 20% by weight of the formed beads have a relative density greater than I.O. The vitrifiable oxide forming elements of said glass-former composition may be chemically interlinked, and the feedstock may be prepared as a silica-based gel or precipitate having a composition suitable for vitrification into a glass of any desired composition for example one which by virtue of its low alkali content is resistant to hydrolytic attack.

Abstract: An electrochromic device comprising a solid layered structure. The structure includes a pair of electrodes and an electrochromic layer sandwiched between the pair of electrodes. The device is sandwiched between a pair of vitreous sheets of which at least one is transparent with a reservoir of ionizable material being held between the sheets. On application of an electrical potential between the electrodes, ions are permitted to migrate between the ionizable material and the electrochromic layer.

Abstract: A method of manufacturing a composite which includes a mirror panel comprising the steps of water-tightly bonding a first backing sheet made of waterproof material to the rear side of a mirror including a vitreous sheet bearing a radiation-reflecting coating on its rear side, thereby forming a mirror/backing sheet laminate; locating the laminate and a second backing sheet between a pair of dies with the laminate and the second backing positioned in spaced relationship; injecting the space between the laminate and the second backing sheet with a foamable plastic material; allowing or causing the foamable plastic material to foam and thereby press the laminate and the second backing sheet into close conformity with the respective die faces and, allowing or causing the foam to set and adhere to each backing sheet while the laminate and second backing sheet are pressed against the die faces to form a substantially rigid composite sandwich structure.