Abstract: A single use container for accurately dispensing separately housed sterile compositions with minimal contact to non-sterile surfaces of the container is disclosed. Embodiments include a container having a first and second chamber within the container for housing a first and second sterile composition. Each chamber has an angled channel which defines an axis for directing the sterile composition from their respective chambers. The angled channels are directed toward each other and are so angled as to minimize contact of the escaping sterile compositions with a non-sterile surface of the container, e.g. the tip. A plurality of tear-off closures seal the angled channels to prevent the sterile compositions from escaping from their respective chambers and a tab portion is provided joining the plurality of closures. Removing the tab portion causes all of the solid closures to be removed in a single action.

Abstract: A Venturi is formed in a portion of the passage of a metal tube by drilling an opening in the downstream part of the tube wall at that portion and deforming the metal at the upstream part of the wall inwardly by a cold flow of the metal so as to define a step in that portion with the opening at the downstream end of that step.