Patents by Inventor Frank Balis

Frank Balis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pteridine nucleotide analogs
    Patent number: 6716971
    Abstract: The invention provides pteridine nucleotides of formula (I) which are highly fluorescent and which can be used in the chemical synthesis of fluorescent oligonucleotide. The invention further provides for fluorescent oligonucleotide comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures. The pteridine nucleotides are more stable and possess higher quantum yields than structurally similar pteridine nucleotides.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: April 6, 2004
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Mary E. Hawkins, Wolfgang Pfleiderer, Frank Balis
  • Pteridine nucletide analogs as fluorescent DNA probes
    Patent number: 5612468
    Abstract: The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotides. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: March 18, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Mary E. Hawkins, Wolfgang Pfleiderer, Michael D. Davis, Frank Balis
  • Pteridine nucleotide analogs as fluorescent DNA probes
    Patent number: 5525711
    Abstract: The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotidcs. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.
    Type: Grant
    Filed: May 18, 1994
    Date of Patent: June 11, 1996
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Mary E. Hawkins, Wolfgang Pfleiderer, Michael D. Davis, Frank Balis