Abstract: The present invention is directed to the combination therapy of cancer with a BRAF inhibitor and a MEK inhibitor, as well as uses and pharmaceutical compositions thereof.

Abstract: A light source comprising a heatable filament (1) or an electrode, wherein the filament (1) or the electrode is arranged in a lamp (2) or in a tube. In order to use the light source in a wide variety of manners even in rough conditions, the filament (1) or the electrode is provided at least partially with a mechanical stabilization system. The invention also relates to a method for mechanical stabilization of the filament (1) or electrode of a light source, wherein stabilization is produced by exposing the filament (1) or electrode to a short pulsed gas pressure increase, involving a rare gas, during heating. Stabilization may also be produced by a coating or deposition (4).

Abstract: An incandescent lamp having a carbide containing luminous element, uses a wire for the luminous element that is coated on the outside with at least two different high melting metal compounds from at least one of the groups of carbides, borides and nitrides. The luminous element reaches a temperature of at least 3000° K during operation.