Patents by Inventor Frank Henri Johan Schuren
Frank Henri Johan Schuren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230330663Abstract: A system for investigating a membrane including a sealing chamber containing a liquid container is described. The liquid container is configured to hold a liquid medium in open communication with a controlled atmosphere inside the sealing chamber. A flow cell is disposed outside the sealing chamber and includes flow channels separated by the tissue. A set of liquid ducts is connected to one of the flow channels and configured to carry the liquid medium from the liquid container, through a barrier of the sealing chamber to an entrance of the flow channel into the flow cell, and carry at least part of the liquid medium exiting the flow channel from the flow cell back into the liquid container.Type: ApplicationFiled: September 7, 2021Publication date: October 19, 2023Inventors: Joanne Mariska DONKERS, Hossein ESLAMI AMIRABADI, Eveline Julia STREEKSTRA, Josse Johan Bernhard BOUWHUIS, Frank Henri Johan SCHUREN, Michel OSSENDRIJVER, Evita VAN DE STEEG
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Patent number: 10619458Abstract: A computer supported method, computer system and computer program product for exploring and producing a subsurface heterogeneous hydrocarbon source and generating a predictive production map of an area under investigation, based on microbial prospecting. Microbial data representative of microbial activity attributable to hydrocarbon microseepage and hydrocarbon productivity data of a plurality of geographic locations are retrieved and correlated by the computer in a data correlation algorithm, providing a threshold hydrocarbon productivity quantity and a truncated set of the retrieved microbial data. The set identifies individual types of the microorganisms and corresponding individual weighting factors computed by the data correlation algorithm, for distinguishing prospective hydrocarbon productivity quantities from non-prospective hydrocarbon productivity quantities.Type: GrantFiled: February 9, 2016Date of Patent: April 14, 2020Assignee: BIODENTIFY B.V.Inventors: Christianus Bernardus Maria Te Stroet, Roy Christiaan Montijn, Evgeni Levin, Frank Henri Johan Schuren
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Patent number: 10596164Abstract: The present invention relates to compounds having a backbone structure for use as antibiotic, more specifically use against infections with Gram positive bacteria, preferably Clostridium, more preferably C. dfficile or C. perfringens. The compounds of the invention are particularly useful against spores of these bacteria.Type: GrantFiled: April 14, 2015Date of Patent: March 24, 2020Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNOInventors: Frank Henri Johan Schuren, Roy Christiaan Montijn
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Publication number: 20180023371Abstract: A computer supported method, computer system and computer program product for exploring and producing a subsurface heterogeneous hydrocarbon source and generating a predictive production map of an area under investigation, based on microbial prospecting. Microbial data representative of microbial activity attributable to hydrocarbon microseepage and hydrocarbon productivity data of a plurality of geographic locations are retrieved and correlated by the computer in a data correlation algorithm, providing a threshold hydrocarbon productivity quantity and a truncated set of the retrieved microbial data. The set identifies individual types of the microorganisms and corresponding individual weighting factors computed by the data correlation algorithm, for distinguishing prospective hydrocarbon productivity quantities from non-prospective hydrocarbon productivity quantities.Type: ApplicationFiled: February 9, 2016Publication date: January 25, 2018Inventors: Christianus Bernardus Maria TE STROET, Roy Christiaan MONTIJN, Evgeni LEVIN, Frank Henri Johan SCHUREN
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Publication number: 20170035750Abstract: The present invention relates to compounds having a backbone structure for use as antibiotic, more specifically use against infections with Gram positive bacteria, preferably Clostridium, more preferably C. difficile or C. perfringens. The compounds of the invention are particularly useful against spores of these bacteria.Type: ApplicationFiled: April 14, 2015Publication date: February 9, 2017Applicant: Nederlandse Organisatie voor toegepast-natuurweten schappelijk Onderzoek TNOInventors: Frank Henri Johan SCHUREN, Roy Christiaan MONTIJN
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Publication number: 20160206668Abstract: The present invention is directed to a method of treating a dysbiosis in a mammal, preferably a human, by taking a sample of the micro-organisms that are causative of the dysbiosis, whereafter said sample is enriched in vitro for healthy bacteria, after which the sample is replaced.Type: ApplicationFiled: August 22, 2014Publication date: July 21, 2016Inventors: Remco Kort, Frank Henri Johan Schuren
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Patent number: 8986946Abstract: The invention relates to a method for real-time detection of viable microorganisms comprising: a. addition of a cell-permeable, phototautomeric compound to a micro-organism or other living cell; and b. measuring the fluorescent emission of said phototautomeric compound. Preferably the phototautomeric compound is salicylic acid, 2-hydroxy-1-naphtoic acid or 1-hydroxy-2-naphtoic acid. Further, the assay can he used to assess the antibiotic effect of a test compound. This test can be used as a high—throughput screening for compounds with antibiotic activity. Also part of the invention is the use of a cell permeable phototautomeric compound in a method for determining the viability of micro-organisms and for assessing the antibiotic effect of a test compound.Type: GrantFiled: December 19, 2008Date of Patent: March 24, 2015Assignee: Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek TnoInventors: Remco Kort, Frank Henri Johan Schuren, Roy Christiaan Montijn
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Patent number: 8808996Abstract: The invention relates to a method of detecting Legionella pneumophila strains by hybridizing genomic DNA of a sample suspected to contain Legionella to one or morespecific sequence markers, as identified by SEQ ID NO:1 through SEQ ID NO:10 or homologues thereof or in an immunoassay with antibodies specifically recognizing the amino acid sequence of SEQ ID NO: 11 and/or 12. The invention further relates to a kit of parts comprising an array and reference materials for performing a method of the invention.Type: GrantFiled: July 1, 2009Date of Patent: August 19, 2014Assignees: Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNO, Vitens N.V.Inventors: Frank Henri Johan Schuren, Waatze Aize Atsma
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Patent number: 8415105Abstract: The invention relates to a method of detecting pathogenic Legionella pneumophila strains by hybridizing genomic DNA of a sample suspected to contain Legionella to two or five specific sequence markers, as identified by MARKER NO. 1 through MARKER NO. 5 or homologues thereof. The invention further relates to a kit of parts comprising an array and reference materials for performing a method of the invention.Type: GrantFiled: December 28, 2007Date of Patent: April 9, 2013Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNOInventors: Frank Henri Johan Schuren, Roy Christiaan Montijn, Henricus Matheus Wilhelmus Maria Thijssen
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Patent number: 8058468Abstract: The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds around the lead compound (3,4-dichloro-phenyl)-carbamic acid 2-isobutoxycarbonylamino-1-methyl-ethyl ester, which are especially useful for combating infections with gram-positive bacteria and especially MRSA.Type: GrantFiled: December 21, 2006Date of Patent: November 15, 2011Assignee: Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek TNOInventors: Frank Henri Johan Schuren, Henricus Matheus Wilhelmus Maria Thijssen, Roy Christiaan Montijn
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Publication number: 20110207127Abstract: The invention relates to a method of detecting Legionella pneumophila strains by hybridizing genomic DNA of a sample suspected to contain Legionella to one or morespecific sequence markers, as identified by SEQ ID NO:1 through SEQ ID NO:10 or homologues thereof or in an immunoassay with antibodies specifically recognizing the amino acid sequence of SEQ ID NO: 11 and/or 12. The invention further relates to a kit of parts comprising an array and reference materials for performing a method of the invention.Type: ApplicationFiled: July 1, 2009Publication date: August 25, 2011Applicant: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELLIJKInventors: Frank Henri Johan Schuren, Waatce Aize Atsma
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Patent number: 7964625Abstract: The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds, the bis(1-aryl-5-tetrazolyl)methanes, which are especially useful for combating infections with gram-positive bacteria and especially MRSA.Type: GrantFiled: September 29, 2006Date of Patent: June 21, 2011Assignee: Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek TnoInventors: Frank Henri Johan Schuren, Henricus Matheus Wilhelmus Maria Thijssen, Roy Christiaan Montijn
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Publication number: 20100130509Abstract: The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds, variants of bis(1-aryl-5-tetrazolyl)methanes, which are especially useful for combating infections with gram-positive bacteria and especially MRSA.Type: ApplicationFiled: April 3, 2008Publication date: May 27, 2010Applicant: Nederlandse Organisatie voor toegepast-natuurwe- tenschappelijk onderzoek TNOInventors: Frank Henri Johan Schuren, Roy Christiaan Montijn
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Publication number: 20100099577Abstract: The invention relates to a method of detecting pathogenic Legionella pneumophila strains by hybridizing genomic DNA of a sample suspected to contain Legionella to two or five specific sequence markers, as identified by MARKER NO. 1 through MARKER NO. 5 or homologues thereof. The invention further relates to a kit of parts comprising an array and reference materials for performing a method of the invention.Type: ApplicationFiled: December 28, 2007Publication date: April 22, 2010Applicant: Nederlandse Organistate Voor Toegepastnatuurwetens Chappelijk Onderzoek TNOInventors: Frank Henri Johan Schuren, Roy Christiaan Montijn, Henricus Matheus Wilhelmus Maria Thijssen
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Publication number: 20090192221Abstract: The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds around the lead compound (3,4-dichloro-phenyl)-carbamic acid 2-isobutoxycarbonylamino-1-methyl-ethyl ester, which are especially useful for combating infections with gram-positive bacteria and especially MRSA.Type: ApplicationFiled: December 21, 2006Publication date: July 30, 2009Applicant: Nederlandse Organisatie voor toegepast-natuurweten sccappelijk onderzoek TNOInventors: Frank Henri Johan Schuren, Henricus Matheus Wilhelmus Maria Thijssen, Roy Christiaan Montijn
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Publication number: 20080280964Abstract: The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds, the bis(1-aryl-5-tetrazolyl)methanes, which are especially useful for combating infections with gram-positive bacteria and especially MRSA.Type: ApplicationFiled: September 29, 2006Publication date: November 13, 2008Applicant: Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek TNOInventors: Frank Henri Johan Schuren, Henricus Matheus Wilhelmus Maria Thijssen, Roy Christiaan Montijn
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Publication number: 20080113872Abstract: The invention relates to a method of preparing clusters of reference hybridization patterns for a sample nucleic acid, comprising providing an array comprising a plurality of nucleic acid molecules, wherein said plurality of nucleic acid molecules is derived from at least two different sources, providing at least two different reference hybridization patterns by hybridizing said array with at least two different reference nucleic acids, wherein the sources of said at least two different reference nucleic acids are separable into at least two groups on the basis of a value for at least one phenotypic parameter, and clustering the reference hybridization patterns by unsupervised multivariate analysis.Type: ApplicationFiled: April 29, 2005Publication date: May 15, 2008Inventors: Frank Henri Johan Schuren, Martinus Petrus Maria Caspers, Bianca Johanna Catherina Van der Werff-van der Vat, Roy Christiaan Montijn